Pharmacokinetic Modeling, Simulation, and Development of a Limited Sampling Strategy of Cycloserine in Patients with Multidrug-/Extensively Drug-Resistant Tuberculosis

Background and Objective Multidrug-resistant tuberculosis has much poorer treatment outcomes compared with drug-susceptible tuberculosis because second-line drugs for treating multidrug resistant tuberculosis are less effective and are frequently associated with side effects. Optimization of drug tr...

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Veröffentlicht in:	Clinical pharmacokinetics 2020-07, Vol.59 (7), p.899-910
Hauptverfasser:	van der Galiën, Ruben, Boveneind-Vrubleuskaya, Natasha van’t, Peloquin, Charles, Skrahina, Alena, Touw, Daan J., Alffenaar, Jan-Willem C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug dosages Drug resistance Internal Medicine Medicine Medicine & Public Health Metabolism Monte Carlo simulation Multidrug resistant organisms Neurotoxicity Original Research Article Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Plasma Population Standard deviation Studies Tuberculosis
Online-Zugang:	Volltext
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