Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression

Irinotecan is an anti-neoplastic agent that is widely used for treating colorectal and lung cancers, but often causes toxicities such as severe myelosuppression and diarrhea. In this study, we performed a two-stage case–control association study for irinotecan-induced severe myelosuppression (grades...

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Veröffentlicht in:	Journal of human genetics 2009-10, Vol.54 (10), p.572-580
Hauptverfasser:	Cha, Pei-Chieng, Mushiroda, Taisei, Zembutsu, Hitoshi, Harada, Hiromasa, Shinoda, Noriyuki, Kawamoto, Shunji, Shimoyama, Rai, Nishidate, Toshihiko, Furuhata, Tomohisa, Sasaki, Kazuaki, Hirata, Koichi, Nakamura, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - therapeutic use ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics Biomedical and Life Sciences Biomedicine Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Camptothecin - therapeutic use Case-Control Studies Diarrhea Female Gene Expression Gene Function Gene polymorphism Gene Therapy Human Genetics Humans Immune Tolerance - drug effects Immune Tolerance - genetics Irinotecan Male Middle Aged Models, Biological Molecular Medicine Myelosuppression Neoplasm Proteins - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism original-article Polymorphism Polymorphism, Single Nucleotide - physiology Retrospective Studies Single-nucleotide polymorphism Toxicity
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