Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells

Botulinum neurotoxin (BoNT) is the causative agent of botulism in humans and animals. Only BoNT serotype A subtype 1 (BoNT/A1) is used clinically because of its high potency and long duration of action. BoNT/A1 and BoNT/A subtype 2 (BoNT/A2) have a high degree of amino acid sequence similarity in th...

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Veröffentlicht in:	Microbiology and immunology 2020-07, Vol.64 (7), p.502-511
Hauptverfasser:	Kohda, Tomoko, Tsukamoto, Kentaro, Torii, Yasushi, Kozaki, Shunji, Mukamoto, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Animals botulinum neurotoxin Botulinum toxin type A Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - genetics Botulism Cells, Cultured Clostridium botulinum - metabolism Endopeptidases Escherichia coli - metabolism Mice Neurons - metabolism Neurotoxicity potency Protein Binding Protein Domains Recombinant Proteins - chemistry Recombinant Proteins - genetics SNAP‐25 subtypes translocation domain
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