Azacitidine‐associated haemorrhagic enteritis in a case of myelodysplastic syndrome: A case report
What is known and objective 5‐Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS). Case description We herein report an 83‐year‐old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrh...
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| Veröffentlicht in: | Journal of clinical pharmacy and therapeutics 2020-08, Vol.45 (4), p.828-831 |
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| container_title | Journal of clinical pharmacy and therapeutics |
| container_volume | 45 |
| creator | Hagino, Takeshi Shinomiya, Wataru Hidai, Hiroko Umeda, Miki Kurimoto, Miwa Saga, Reina Tsutsumi, Hisashi Shibata, Yoshiaki Akiyama, Hideki Motomura, Sayuri |
| description | What is known and objective
5‐Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS).
Case description
We herein report an 83‐year‐old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with multiple intestinal ulcers developed after the second and third cycles. Additionally, the interval between the administration of AZA and the development of haematochezia shortened with each cycle of AZA.
What is new and Conclusion
We herein report as‐yet‐undescribed potential side effects, AZA‐associated haemorrhagic enteritis that should be kept in mind. |
| doi_str_mv | 10.1111/jcpt.13146 |
| format | Article |
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5‐Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS).
Case description
We herein report an 83‐year‐old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with multiple intestinal ulcers developed after the second and third cycles. Additionally, the interval between the administration of AZA and the development of haematochezia shortened with each cycle of AZA.
What is new and Conclusion
We herein report as‐yet‐undescribed potential side effects, AZA‐associated haemorrhagic enteritis that should be kept in mind.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/jcpt.13146</identifier><identifier>PMID: 32436280</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Aged, 80 and over ; azacitidine ; Azacitidine - adverse effects ; Case reports ; colitis ; Colonoscopy ; Enteritis ; Enteritis - chemically induced ; Female ; Gastrointestinal Hemorrhage - chemically induced ; haemorrhagic enteritis ; Humans ; Intestine ; Myelodysplastic syndrome ; Myelodysplastic syndromes ; Myelodysplastic Syndromes - drug therapy ; Ulcers</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2020-08, Vol.45 (4), p.828-831</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3606-893ea11dd056cb28b2c8acaa441e38d3f826ef753db7c3480239a47f285e2ee63</citedby><cites>FETCH-LOGICAL-c3606-893ea11dd056cb28b2c8acaa441e38d3f826ef753db7c3480239a47f285e2ee63</cites><orcidid>0000-0002-3164-9641 ; 0000-0001-5788-8555</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpt.13146$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpt.13146$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32436280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagino, Takeshi</creatorcontrib><creatorcontrib>Shinomiya, Wataru</creatorcontrib><creatorcontrib>Hidai, Hiroko</creatorcontrib><creatorcontrib>Umeda, Miki</creatorcontrib><creatorcontrib>Kurimoto, Miwa</creatorcontrib><creatorcontrib>Saga, Reina</creatorcontrib><creatorcontrib>Tsutsumi, Hisashi</creatorcontrib><creatorcontrib>Shibata, Yoshiaki</creatorcontrib><creatorcontrib>Akiyama, Hideki</creatorcontrib><creatorcontrib>Motomura, Sayuri</creatorcontrib><title>Azacitidine‐associated haemorrhagic enteritis in a case of myelodysplastic syndrome: A case report</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>What is known and objective
5‐Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS).
Case description
We herein report an 83‐year‐old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with multiple intestinal ulcers developed after the second and third cycles. Additionally, the interval between the administration of AZA and the development of haematochezia shortened with each cycle of AZA.
What is new and Conclusion
We herein report as‐yet‐undescribed potential side effects, AZA‐associated haemorrhagic enteritis that should be kept in mind.</description><subject>Aged, 80 and over</subject><subject>azacitidine</subject><subject>Azacitidine - adverse effects</subject><subject>Case reports</subject><subject>colitis</subject><subject>Colonoscopy</subject><subject>Enteritis</subject><subject>Enteritis - chemically induced</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - chemically induced</subject><subject>haemorrhagic enteritis</subject><subject>Humans</subject><subject>Intestine</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic syndromes</subject><subject>Myelodysplastic Syndromes - drug therapy</subject><subject>Ulcers</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90LtOwzAYhmELgWgpLFwAssSGlOJD4iRsVcVRlWAos-XYf2iqJA52KhQmLoFr5EpISWHEi5dH7y99CJ1SMqX9u1zrpp1STkOxh8aUiyhgMSX7aEyYSIMwZvEIHXm_JoSImPFDNOIs5IIlZIzM7F3poi1MUcPXx6fy3upCtWDwSkFlnVupl0JjqFtwPfO4qLHCWnnANsdVB6U1nW9K5due-a42zlZwhWeDcdBY1x6jg1yVHk52_wQ931wv53fB4vH2fj5bBJoLIoIk5aAoNYZEQmcsyZhOlFYqDCnwxPA8YQLyOOImizUPE8J4qsI4Z0kEDEDwCTofuo2zrxvwrVzbjav7k5KFjBCeUh716mJQ2lnvHeSycUWlXCcpkdtB5XZQ-TNoj892yU1Wgfmjvwv2gA7grSih-yclH-ZPyyH6DZqsgms</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Hagino, Takeshi</creator><creator>Shinomiya, Wataru</creator><creator>Hidai, Hiroko</creator><creator>Umeda, Miki</creator><creator>Kurimoto, Miwa</creator><creator>Saga, Reina</creator><creator>Tsutsumi, Hisashi</creator><creator>Shibata, Yoshiaki</creator><creator>Akiyama, Hideki</creator><creator>Motomura, Sayuri</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><orcidid>https://orcid.org/0000-0002-3164-9641</orcidid><orcidid>https://orcid.org/0000-0001-5788-8555</orcidid></search><sort><creationdate>202008</creationdate><title>Azacitidine‐associated haemorrhagic enteritis in a case of myelodysplastic syndrome: A case report</title><author>Hagino, Takeshi ; Shinomiya, Wataru ; Hidai, Hiroko ; Umeda, Miki ; Kurimoto, Miwa ; Saga, Reina ; Tsutsumi, Hisashi ; Shibata, Yoshiaki ; Akiyama, Hideki ; Motomura, Sayuri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3606-893ea11dd056cb28b2c8acaa441e38d3f826ef753db7c3480239a47f285e2ee63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged, 80 and over</topic><topic>azacitidine</topic><topic>Azacitidine - adverse effects</topic><topic>Case reports</topic><topic>colitis</topic><topic>Colonoscopy</topic><topic>Enteritis</topic><topic>Enteritis - chemically induced</topic><topic>Female</topic><topic>Gastrointestinal Hemorrhage - chemically induced</topic><topic>haemorrhagic enteritis</topic><topic>Humans</topic><topic>Intestine</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic syndromes</topic><topic>Myelodysplastic Syndromes - drug therapy</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagino, Takeshi</creatorcontrib><creatorcontrib>Shinomiya, Wataru</creatorcontrib><creatorcontrib>Hidai, Hiroko</creatorcontrib><creatorcontrib>Umeda, Miki</creatorcontrib><creatorcontrib>Kurimoto, Miwa</creatorcontrib><creatorcontrib>Saga, Reina</creatorcontrib><creatorcontrib>Tsutsumi, Hisashi</creatorcontrib><creatorcontrib>Shibata, Yoshiaki</creatorcontrib><creatorcontrib>Akiyama, Hideki</creatorcontrib><creatorcontrib>Motomura, Sayuri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of clinical pharmacy and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagino, Takeshi</au><au>Shinomiya, Wataru</au><au>Hidai, Hiroko</au><au>Umeda, Miki</au><au>Kurimoto, Miwa</au><au>Saga, Reina</au><au>Tsutsumi, Hisashi</au><au>Shibata, Yoshiaki</au><au>Akiyama, Hideki</au><au>Motomura, Sayuri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azacitidine‐associated haemorrhagic enteritis in a case of myelodysplastic syndrome: A case report</atitle><jtitle>Journal of clinical pharmacy and therapeutics</jtitle><addtitle>J Clin Pharm Ther</addtitle><date>2020-08</date><risdate>2020</risdate><volume>45</volume><issue>4</issue><spage>828</spage><epage>831</epage><pages>828-831</pages><issn>0269-4727</issn><eissn>1365-2710</eissn><abstract>What is known and objective
5‐Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS).
Case description
We herein report an 83‐year‐old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with multiple intestinal ulcers developed after the second and third cycles. Additionally, the interval between the administration of AZA and the development of haematochezia shortened with each cycle of AZA.
What is new and Conclusion
We herein report as‐yet‐undescribed potential side effects, AZA‐associated haemorrhagic enteritis that should be kept in mind.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>32436280</pmid><doi>10.1111/jcpt.13146</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-3164-9641</orcidid><orcidid>https://orcid.org/0000-0001-5788-8555</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged, 80 and over azacitidine Azacitidine - adverse effects Case reports colitis Colonoscopy Enteritis Enteritis - chemically induced Female Gastrointestinal Hemorrhage - chemically induced haemorrhagic enteritis Humans Intestine Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - drug therapy Ulcers |
| title | Azacitidine‐associated haemorrhagic enteritis in a case of myelodysplastic syndrome: A case report |
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