Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities
Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodiu...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2020/07/01, Vol.68(7), pp.671-674 |
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| creator | Boonyaketgoson, Sirada Du, Yongle Murillo, Ana L. Valenciano Cassera, Maria B. Kingston, David G. I. Trisuwan, Kongkiat |
| description | Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM. |
| doi_str_mv | 10.1248/cpb.c20-00080 |
| format | Article |
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Valenciano ; Cassera, Maria B. ; Kingston, David G. I. ; Trisuwan, Kongkiat</creator><creatorcontrib>Boonyaketgoson, Sirada ; Du, Yongle ; Murillo, Ana L. Valenciano ; Cassera, Maria B. ; Kingston, David G. I. ; Trisuwan, Kongkiat ; Chiang Mai University ; cDepartment of Biochemistry and Molecular Biology ; and Center for Tropical and Emerging Global Diseases (CTEGD ; aDepartment of Chemistry and Center of Excellence for Innovation in Chemistry ; bDepartment of Chemistry ; Virginia Tech ; University of Georgia ; dResearch Center on Chemistry for Development of Health Promoting Products from Northern Resources ; Faculty of Science</creatorcontrib><description>Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c20-00080</identifier><identifier>PMID: 32612002</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Acetone ; antimycobacterial activity ; antiplasmodial activity ; Antiprotozoal agents ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Antitubercular Agents - chemistry ; Antitubercular Agents - isolation & purification ; Antitubercular Agents - pharmacology ; Artocarpus ; Artocarpus - chemistry ; Artocarpus lakoocha ; Cell Line, Tumor ; Cell Survival - drug effects ; cytotoxic activity ; Cytotoxicity ; Dose-Response Relationship, Drug ; Flavanones - chemistry ; Flavanones - isolation & purification ; Flavanones - pharmacology ; Humans ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Molecular Structure ; Mycobacterium tuberculosis - drug effects ; Parasitic Sensitivity Tests ; Plant Bark - chemistry ; Plant Stems - chemistry ; Plasmodium falciparum - drug effects ; Structure-Activity Relationship ; Tuberculosis</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2020/07/01, Vol.68(7), pp.671-674</ispartof><rights>2020 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-a3509d030cf60509492a4101b86b04534eae2e1eac3da837e84209434fdb63893</citedby><cites>FETCH-LOGICAL-c702t-a3509d030cf60509492a4101b86b04534eae2e1eac3da837e84209434fdb63893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32612002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boonyaketgoson, Sirada</creatorcontrib><creatorcontrib>Du, Yongle</creatorcontrib><creatorcontrib>Murillo, Ana L. Valenciano</creatorcontrib><creatorcontrib>Cassera, Maria B.</creatorcontrib><creatorcontrib>Kingston, David G. I.</creatorcontrib><creatorcontrib>Trisuwan, Kongkiat</creatorcontrib><creatorcontrib>Chiang Mai University</creatorcontrib><creatorcontrib>cDepartment of Biochemistry and Molecular Biology</creatorcontrib><creatorcontrib>and Center for Tropical and Emerging Global Diseases (CTEGD</creatorcontrib><creatorcontrib>aDepartment of Chemistry and Center of Excellence for Innovation in Chemistry</creatorcontrib><creatorcontrib>bDepartment of Chemistry</creatorcontrib><creatorcontrib>Virginia Tech</creatorcontrib><creatorcontrib>University of Georgia</creatorcontrib><creatorcontrib>dResearch Center on Chemistry for Development of Health Promoting Products from Northern Resources</creatorcontrib><creatorcontrib>Faculty of Science</creatorcontrib><title>Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.</description><subject>Acetone</subject><subject>antimycobacterial activity</subject><subject>antiplasmodial activity</subject><subject>Antiprotozoal agents</subject><subject>Antiprotozoal Agents - chemistry</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antitubercular Agents - chemistry</subject><subject>Antitubercular Agents - isolation & purification</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Artocarpus</subject><subject>Artocarpus - chemistry</subject><subject>Artocarpus lakoocha</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>cytotoxic activity</subject><subject>Cytotoxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flavanones - chemistry</subject><subject>Flavanones - isolation & purification</subject><subject>Flavanones - pharmacology</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>Molecular Structure</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Parasitic Sensitivity Tests</subject><subject>Plant Bark - chemistry</subject><subject>Plant Stems - chemistry</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Structure-Activity Relationship</subject><subject>Tuberculosis</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1v2zAQxYmiReOmHbsWBDorOX6IokbHaJICAbK4M3GiKJuOJKqk7KL_fWk7dZYjeffje4dHyFcGN4xLfWun5sZyKABAwzuyYEJWRcm5eE8WuVcXXChxRT6ltAPgJVTiI7kSXDGenwuyue_xgGMYXaJdDAOdt46u__hNoji29A7jS6Kho8s4B4tx2ifa40sIdov0EQ9-3NDlOPupxzSE1mN_-nZsFes7urSzP_jZu_SZfOiwT-7L63lNft3_WK8ei6fnh5-r5VNhK-BzgaKEugUBtlOQr7LmKBmwRqsGZCmkQ8cdc2hFi1pUTkueKSG7tlFC1-KafD_rTjH83rs0m13YxzFbGi5ZLSshlcxUcaZsDClF15kp-gHjX8PAHGM1OVaTYzWnWDP_7VV13wyuvdD_c8zAwxnIU2-xD2PvR_fmbVNlt27whsNJVGmoDDBhQFXsWKQoleZCZ6XVWWmXZty4ixXG2dvenRZT2lTHclnwbbrFaNwo_gE0VaBK</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Boonyaketgoson, Sirada</creator><creator>Du, Yongle</creator><creator>Murillo, Ana L. 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I. ; Trisuwan, Kongkiat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-a3509d030cf60509492a4101b86b04534eae2e1eac3da837e84209434fdb63893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetone</topic><topic>antimycobacterial activity</topic><topic>antiplasmodial activity</topic><topic>Antiprotozoal agents</topic><topic>Antiprotozoal Agents - chemistry</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antitubercular Agents - chemistry</topic><topic>Antitubercular Agents - isolation & purification</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Artocarpus</topic><topic>Artocarpus - chemistry</topic><topic>Artocarpus lakoocha</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>cytotoxic activity</topic><topic>Cytotoxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flavanones - chemistry</topic><topic>Flavanones - isolation & purification</topic><topic>Flavanones - pharmacology</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Minimum inhibitory concentration</topic><topic>Molecular Structure</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Parasitic Sensitivity Tests</topic><topic>Plant Bark - chemistry</topic><topic>Plant Stems - chemistry</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Structure-Activity Relationship</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boonyaketgoson, Sirada</creatorcontrib><creatorcontrib>Du, Yongle</creatorcontrib><creatorcontrib>Murillo, Ana L. 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Bull.</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>68</volume><issue>7</issue><spage>671</spage><epage>674</epage><pages>671-674</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>32612002</pmid><doi>10.1248/cpb.c20-00080</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Acetone antimycobacterial activity antiplasmodial activity Antiprotozoal agents Antiprotozoal Agents - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Artocarpus Artocarpus - chemistry Artocarpus lakoocha Cell Line, Tumor Cell Survival - drug effects cytotoxic activity Cytotoxicity Dose-Response Relationship, Drug Flavanones - chemistry Flavanones - isolation & purification Flavanones - pharmacology Humans Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Structure Mycobacterium tuberculosis - drug effects Parasitic Sensitivity Tests Plant Bark - chemistry Plant Stems - chemistry Plasmodium falciparum - drug effects Structure-Activity Relationship Tuberculosis |
| title | Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities |
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