Assessment of Cytotoxicity Induced by Hazardous Chemotherapeutic Drugs Cyclophosphamide and 5-Fluorouracil in Allium cepa Assay for Ecological Safety

Allium cepa (2n=16) assay is conducted to ascertain cytotoxicity of two most used hazardous chemotherapeutic drugs namely, cyclophosphamide (CP) and 5-fluorouracil (5-FU) (doses at much lower than pharmaceutical concentrations—0.025, 0.050, 0.100, 0.250 and 0.500 g L−1 for 24 h) to ascertain possibl...

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Veröffentlicht in:	CYTOLOGIA 2020/06/25, Vol.85(2), pp.151-155
Hauptverfasser:	Gupta, Sudha, Das, Debadrito, Mitra, Prashanta Kumar, Halder, Sandip, Datta, Animesh Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Allium cepa Allium test Chromosomes Cyclophosphamide Cytotoxicity Disintegration Drugs Ecological safety Giant cells Metabolism Mitotic aberration Nuclear engineering Nuclear safety Toxicity
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