299-OR: Loss of Insulin and IGF1 Receptors in Muscle Impairs Complex-I Dependent Mitochondrial Bioenergetics and Supercomplex Formation via Foxo Transcription Factors

Diabetes is associated with decreased muscle strength and mitochondrial metabolism which can lead to disability. Recently, we reported that insulin receptor (IR) and IGF-1 receptor (IGF1R) prevent muscle atrophy via suppression of FoxOs, but how FoxOs interact with mitochondrial function remains unc...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser:	BHARDWAJ, GOURAV, PENNIMAN, CHRISTIE M., BELTRAN, PABLO A. SUAREZ, JENA, JAYASHREE, FOSTER, COLLIN M., PORO, KENNEDY, JUNCK, TAYLOR, HINTON, ANTENTOR, SOUVENIR, RHONDA, FUQUA, JORDAN, MORALES, PABLO E., BRAVO-SAGUA, ROBERTO, LIRA, VITOR A., ABEL, EVAN D., ONEILL, BRIAN T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy Autophagy Bioenergetics Biosensors Diabetes mellitus Electron transport Forkhead protein FOXO1 protein Insulin Insulin-like growth factor I Mitochondria Muscle strength Myotubes Phagocytosis Pyruvic acid Respiration Ribonucleic acid RNA Rotenone Tamoxifen Transcription factors
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