1718-P: Heme Oxygenase-1 Promotes Hepatic Glucose Production via Increasing the Intracellular Ferrous Iron

The heme oxygenase-1 (HO1) catalyzes the degradation of heme into biliverdin, ferrous iron and carbon monoxide (CO). Although HO1 has long been considered as an anti-inflammatory molecule, recent studies showed that HO1 disrupts the mitochondrial function in hepatocytes, as well as drives inflammati...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser:	LIAO, WANG, YANG, WANBAO, PAN, QUAN, SHEN, ZHENG, AI, WEIQI, GUO, SHAODONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliverdin Carbon monoxide Deferoxamine Diabetes Forkhead protein FOXO1 protein Glucagon Glucose Glucose metabolism Heme Heme oxygenase (decyclizing) Hepatocytes Inflammation Insulin Intracellular Iron Liver Mitochondria NF-κB protein Oxygenase Phosphorylation siRNA
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