44-OR: PAR2-Regulated MIF Secretion from Non-Immune Cells in Adipose Tissue Is a Key Mechanism Involved in the Development of Metabolic Dysfunction

Macrophage migration inhibitory factor (MIF) is a cytokine that is increased in obesity and contributes to metabolic dysfunction. Our present study describes a novel mechanism by which fatty acids activate non-immune cells to increase MIF secretion in adipose tissue, initiating cross-talk between pr...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser:	HUANG, YIHENG, CHEN, LIUJUN, QI, YADAN, QI, DAKE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Autocrine signalling Diabetes mellitus (non-insulin dependent) Fatty acids High fat diet Leukocyte migration Macrophage migration inhibitory factor Metabolism Migration inhibitory factor Obesity Paracrine signalling Preadipocyte factor 1
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