2165-PUB: Jabuticaba Juice Improve Glucagon-Like Peptide-1 in Healthy Participants: Results from a Pilot, Single-Blinded, Randomized Controlled Trial

Introduction: The effects of jabuticaba on health, particularly on glucose metabolism and GLP-1 deserve further clinical investigation. Objective: The objective was to evaluate whether consumption of a jabuticaba juice preload containing 503 mg gallic acid equivalent and 2g of fibers would exert any effect on postprandial glycaemia, insulin, C-peptide, GLP-1, and appetite sensations. Methods: Sixteen healthy subjects (11 women; 5 men; 28.4 ± 3.8 years; BMI 21.7 ± 2.3 kg m−2) completed a randomized, crossover intervention study. Jabuticaba or control beverage was consumed before a white wheat bread (WWB) challenge meal. Blood samples were taken frequently over the following 2 h. Blood glucose, serum insulin, C-peptide, and antioxidant capacity, plasma GLP-1, and appetite sensations were evaluated. Results: Postprandial GLP-1 response as AUC, was higher after consumption of jabuticaba juice compared with control (95.6±41.4 vs. 82.7±24.6 ng/mL; p = 0.03). The GLP-1 significantly increased after jabuticaba juice, peaking at 60 min (1.21±0.5 vs. 0.71±0.2 ng/mL; p = 0,019). The AUC of antioxidant capacity was higher for jabuticaba juice vs. control (37.9±19.4 mmol TE/mL vs. 32.4±8.4; p = 0.005). Postprandial glucose, insulin, C-peptide levels, and appetite sensations were not significantly different between groups. Conclusion: Inclusion of jabuticaba juice before a WWB challenge meal might be beneficial for antioxidant status and GLP-1 concentrations, but we did not find supporting evidence in glycaemia, C-peptide, insulin, insulin sensitivity and appetite sensations in healthy subjects.