Regioisomer-manipulating thio-perylenediimide nanoagents for photothermal/photodynamic theranostics

Thionated perylenediimides (PDIs) can potentially generate thermal and reactive oxygen species and thus can be used as theranostic agents for photothermal/photodynamic therapy. Herein, thionated cis -/ trans -isomer PDI-CS and PDI-TS were designed and prepared to investigate thionation engineering o...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-07, Vol.8 (25), p.5535-5544
Hauptverfasser:	Liu, Zhonghua, Gao, Yijian, Jin, Xin, Deng, Qingyuan, Yin, Zengle, Tong, Shuaihang, Qing, Weixia, Huang, Yongwei
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bonding Cell Proliferation - drug effects Cell Survival - drug effects Drug Screening Assays, Antitumor Humans Imides - chemical synthesis Imides - chemistry Imides - pharmacology Mice Mice, Inbred BALB C Mice, Nude Molecular Structure Nanoparticles - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Optical Imaging Optimization Particle Size Perylene - analogs & derivatives Perylene - chemical synthesis Perylene - chemistry Perylene - pharmacology Photochemotherapy Photodynamic therapy Photothermal conversion Photothermal Therapy Precision medicine Reactive oxygen species Reactive Oxygen Species - metabolism Stereoisomerism Sulfhydryl Compounds - chemical synthesis Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacology Sulfur Surface Properties Theranostic Nanomedicine Tumor Cells, Cultured
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