Sample Preparation of Biological Tissues and Cells for the Time-of-Flight Secondary Ion Mass Spectrometry

The review is devoted to the application of time-of-flight secondary ion mass spectrometry (ToF–SIMS) to the analysis of biological tissues and cells. The invention of cluster primary ions significantly improved the sensitivity, especially in the mass range above several hundred of Daltons, which op...

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Veröffentlicht in:	Journal of analytical chemistry (New York, N.Y.) N.Y.), 2020-06, Vol.75 (6), p.701-710
Hauptverfasser:	Gulin, A. A., Nadtochenko, V. A., Pogorelova, V. N., Melnikov, M. Ya, Pogorelov, A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analytical Chemistry Biological materials Biological properties Bombardment Chemistry Chemistry and Materials Science Cytology Electron probe microanalysis Histology Ions Lipids Mass spectrometry Metabolites Nucleic acids Particle beams Reviews Scientific imaging Secondary ion mass spectrometry Spectroscopy Tissues Ultrahigh vacuum
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