RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division

Stable propagation of epigenetic information is important for maintaining cell identity in multicellular organisms. However, it remains largely unknown how mono-ubiquitinated histone H2A on lysine 119 (H2AK119ub1) is established and stably propagated during cell division. In this study, we found tha...

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Veröffentlicht in:	Nature cell biology 2020-04, Vol.22 (4), p.439-452
Hauptverfasser:	Zhao, Jicheng, Wang, Min, Chang, Luyuan, Yu, Juan, Song, Aoqun, Liu, Cuifang, Huang, Wenjun, Zhang, Tiantian, Wu, Xudong, Shen, Xiaohua, Zhu, Bing, Li, Guohong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/2 14/28 631/208/176/2016 631/337/100/2285 82 82/58 82/83 Animals Binding proteins Biomedical and Life Sciences Cancer Research Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Division Chromatin Compaction CRISPR-Cas Systems Developmental Biology Epigenesis, Genetic Epigenetic inheritance Epigenetics Feedback Feedback, Physiological Gene Deletion Gene Editing Genetic aspects HEK293 Cells Heredity Histone H1 Histone H2A Histones Histones - genetics Histones - metabolism Humans Life Sciences Lysine Mice Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Nucleosomes Nucleosomes - chemistry Nucleosomes - metabolism Physiological aspects Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Positive feedback Post-translational modification Propagation Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational Protein research Repressor Proteins - genetics Repressor Proteins - metabolism Stem Cells Ubiquitination
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