Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

The aryl hydrocarbon receptor (AHR) is a ligand-activated receptor that regulates the metabolism of several xenobiotics and participates in ocular inflammation. Although severe inflammation is a major risk of retinal damage, the underlying mechanism is not well established. In this study, to elucida...

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Veröffentlicht in:	Cell biology and toxicology 2020-06, Vol.36 (3), p.223-242
Hauptverfasser:	Tsai, Chi-Hao, Lee, Yi, Li, Ching-Hao, Cheng, Yu-Wen, Kang, Jaw-Jou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatic compounds Benzo(a)pyrene - toxicity Biochemistry Biomedical and Life Sciences Carcinogens Cell Biology Cigarette smoke Cigarette smoking Cigarettes Cytokines Damage Disintegration Down-regulation Exposure Homeostasis Hydrocarbons Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Lesions Life Sciences Male Mice Mice, Inbred C57BL Negative feedback Original Article Pharmacology/Toxicology Pyrene Receptors Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Retina Retinal pigment epithelium Signal Transduction Signaling SOCS-3 protein Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Suppressor of Cytokine Signaling 3 Protein - genetics Suppressor of Cytokine Signaling 3 Protein - metabolism Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism Transcription Transcriptional Activation Ubiquitination Visual perception Xenobiotics
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