Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study
Objective Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in population...
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| Veröffentlicht in: | International archives of occupational and environmental health 2020-08, Vol.93 (6), p.707-714 |
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| creator | Wang, Fang Yang, Liuye Zhang, Bin Liu, Gaisheng Wang, Chongjian Zhang, Yawei Wang, Tong |
| description | Objective
Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in populations that are occupationally exposed to PAHs. We tested neurobehavioral performance in coal miners and correlated it with levels of urinary markers of PAH exposure.
Methods
Levels of urinary PAH metabolites were measured in 652 male coal miners as an indicator of exposure. Subjects were divided into a high-exposure group and a low-exposure group based on the median level of total PAH metabolites. A neurobehavioral core test battery and a questionnaire were used to assess neurobehavioral performance and collect demographic information, respectively.
Results
The median level of total PAH metabolites in urine was 4.88 μmol/mol creatinine. Highly exposed workers exhibited more fatigue-inertia than less-exposed workers (
p
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| doi_str_mv | 10.1007/s00420-020-01521-w |
| format | Article |
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Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in populations that are occupationally exposed to PAHs. We tested neurobehavioral performance in coal miners and correlated it with levels of urinary markers of PAH exposure.
Methods
Levels of urinary PAH metabolites were measured in 652 male coal miners as an indicator of exposure. Subjects were divided into a high-exposure group and a low-exposure group based on the median level of total PAH metabolites. A neurobehavioral core test battery and a questionnaire were used to assess neurobehavioral performance and collect demographic information, respectively.
Results
The median level of total PAH metabolites in urine was 4.88 μmol/mol creatinine. Highly exposed workers exhibited more fatigue-inertia than less-exposed workers (
p
< 0.05), and had lower scores in forward digit span, digit symbol, and Benton visual retention tests (
p
< 0.05). Multiple linear regression indicated that age, education, and shift work were significantly correlated with test scores.
Conclusions
PAH exposure may be associated with neurobehavioral alterations, which should be monitored in coal miners to prevent neurobehavioral disorders.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-020-01521-w</identifier><identifier>PMID: 32060638</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Air Pollutants, Occupational - urine ; Behavior ; Biological Monitoring ; China - epidemiology ; Coal ; Coal Mining ; Correlation analysis ; Creatinine ; Cross-Sectional Studies ; Earth and Environmental Science ; Environment ; Environmental Health ; Exposure ; Humans ; Levels ; Male ; Metabolites ; Middle Aged ; Miners ; Neuropsychological Tests ; Neurotoxicity Syndromes - epidemiology ; Occupational exposure ; Occupational Exposure - analysis ; Occupational Medicine/Industrial Medicine ; Original Article ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - urine ; Rehabilitation ; Shift work ; Surveys and Questionnaires</subject><ispartof>International archives of occupational and environmental health, 2020-08, Vol.93 (6), p.707-714</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6648663e4dbfeda9efaf4805ac2b357cff358b489483f4b4ea498e8edf182e993</citedby><cites>FETCH-LOGICAL-c375t-6648663e4dbfeda9efaf4805ac2b357cff358b489483f4b4ea498e8edf182e993</cites><orcidid>0000-0003-0139-7209</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-020-01521-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-020-01521-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32060638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Yang, Liuye</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Liu, Gaisheng</creatorcontrib><creatorcontrib>Wang, Chongjian</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><title>Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Objective
Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in populations that are occupationally exposed to PAHs. We tested neurobehavioral performance in coal miners and correlated it with levels of urinary markers of PAH exposure.
Methods
Levels of urinary PAH metabolites were measured in 652 male coal miners as an indicator of exposure. Subjects were divided into a high-exposure group and a low-exposure group based on the median level of total PAH metabolites. A neurobehavioral core test battery and a questionnaire were used to assess neurobehavioral performance and collect demographic information, respectively.
Results
The median level of total PAH metabolites in urine was 4.88 μmol/mol creatinine. Highly exposed workers exhibited more fatigue-inertia than less-exposed workers (
p
< 0.05), and had lower scores in forward digit span, digit symbol, and Benton visual retention tests (
p
< 0.05). Multiple linear regression indicated that age, education, and shift work were significantly correlated with test scores.
Conclusions
PAH exposure may be associated with neurobehavioral alterations, which should be monitored in coal miners to prevent neurobehavioral disorders.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - urine</subject><subject>Behavior</subject><subject>Biological Monitoring</subject><subject>China - epidemiology</subject><subject>Coal</subject><subject>Coal Mining</subject><subject>Correlation analysis</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Humans</subject><subject>Levels</subject><subject>Male</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Miners</subject><subject>Neuropsychological Tests</subject><subject>Neurotoxicity Syndromes - epidemiology</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - urine</subject><subject>Rehabilitation</subject><subject>Shift work</subject><subject>Surveys and Questionnaires</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1Lw0AQhhdRbP34Ax5kwavR_cpm460UtUJRQT2HTTJrU5ps3E1s--9NTNWbh2Fg3mfeGV6Ezii5ooRE154QwUhA-qIho8F6D42p4CygTMh9NCZc9BKnI3Tk_ZIQGsmIH6IRZ0QSydUYFY_QOpvCQn8W1ukVrsEZ60pdZYCtwc-TGYZNbX3rABcVLvUKcGY7sCwqcL6fvSx0tSku8XRRVPoGa5w5633gIWsKW3Wob9p8e4IOjF55ON31Y_R2d_s6nQXzp_uH6WQeZDwKm0BKoaTkIPLUQK5jMNoIRUKdsZSHUWYMD1UqVCwUNyIVoEWsQEFuqGIQx_wYXQy-tbMfLfgmWdrWdW_4hAkaKcYpER3FBur7VwcmqV1RardNKEn6dJMh3YT01aebrLul8511m5aQ_678xNkBfAB8J1Xv4P5u_2P7BTUMhic</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Wang, Fang</creator><creator>Yang, Liuye</creator><creator>Zhang, Bin</creator><creator>Liu, Gaisheng</creator><creator>Wang, Chongjian</creator><creator>Zhang, Yawei</creator><creator>Wang, Tong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-0139-7209</orcidid></search><sort><creationdate>20200801</creationdate><title>Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study</title><author>Wang, Fang ; Yang, Liuye ; Zhang, Bin ; Liu, Gaisheng ; Wang, Chongjian ; Zhang, Yawei ; Wang, Tong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6648663e4dbfeda9efaf4805ac2b357cff358b489483f4b4ea498e8edf182e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Air Pollutants, Occupational - urine</topic><topic>Behavior</topic><topic>Biological Monitoring</topic><topic>China - epidemiology</topic><topic>Coal</topic><topic>Coal Mining</topic><topic>Correlation analysis</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Exposure</topic><topic>Humans</topic><topic>Levels</topic><topic>Male</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Miners</topic><topic>Neuropsychological Tests</topic><topic>Neurotoxicity Syndromes - epidemiology</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - urine</topic><topic>Rehabilitation</topic><topic>Shift work</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Yang, Liuye</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Liu, Gaisheng</creatorcontrib><creatorcontrib>Wang, Chongjian</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fang</au><au>Yang, Liuye</au><au>Zhang, Bin</au><au>Liu, Gaisheng</au><au>Wang, Chongjian</au><au>Zhang, Yawei</au><au>Wang, Tong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>93</volume><issue>6</issue><spage>707</spage><epage>714</epage><pages>707-714</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><abstract>Objective
Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in populations that are occupationally exposed to PAHs. We tested neurobehavioral performance in coal miners and correlated it with levels of urinary markers of PAH exposure.
Methods
Levels of urinary PAH metabolites were measured in 652 male coal miners as an indicator of exposure. Subjects were divided into a high-exposure group and a low-exposure group based on the median level of total PAH metabolites. A neurobehavioral core test battery and a questionnaire were used to assess neurobehavioral performance and collect demographic information, respectively.
Results
The median level of total PAH metabolites in urine was 4.88 μmol/mol creatinine. Highly exposed workers exhibited more fatigue-inertia than less-exposed workers (
p
< 0.05), and had lower scores in forward digit span, digit symbol, and Benton visual retention tests (
p
< 0.05). Multiple linear regression indicated that age, education, and shift work were significantly correlated with test scores.
Conclusions
PAH exposure may be associated with neurobehavioral alterations, which should be monitored in coal miners to prevent neurobehavioral disorders.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32060638</pmid><doi>10.1007/s00420-020-01521-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0139-7209</orcidid></addata></record> |
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| language | eng |
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| subjects | Adult Air Pollutants, Occupational - urine Behavior Biological Monitoring China - epidemiology Coal Coal Mining Correlation analysis Creatinine Cross-Sectional Studies Earth and Environmental Science Environment Environmental Health Exposure Humans Levels Male Metabolites Middle Aged Miners Neuropsychological Tests Neurotoxicity Syndromes - epidemiology Occupational exposure Occupational Exposure - analysis Occupational Medicine/Industrial Medicine Original Article Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - urine Rehabilitation Shift work Surveys and Questionnaires |
| title | Neurobehavioral performance of PAH exposure in male coal miners in Shanxi, China: a cross-sectional study |
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