Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

In a double-blind trial, patients with type 1 diabetes and early-to-moderate diabetic kidney disease were randomly assigned to receive allopurinol, which may slow the decline in the glomerular filtration rate, or placebo. There were no clinically meaningful benefits of serum urate reduction on kidne...

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Veröffentlicht in:	The New England journal of medicine 2020-06, Vol.382 (26), p.2493-2503
Hauptverfasser:	Doria, Alessandro, Galecki, Andrzej T, Spino, Cathie, Pop-Busui, Rodica, Cherney, David Z, Lingvay, Ildiko, Parsa, Afshin, Rossing, Peter, Sigal, Ronald J, Afkarian, Maryam, Aronson, Ronnie, Caramori, M. Luiza, Crandall, Jill P, de Boer, Ian H, Elliott, Thomas G, Goldfine, Allison B, Haw, J. Sonya, Hirsch, Irl B, Karger, Amy B, Maahs, David M, McGill, Janet B, Molitch, Mark E, Perkins, Bruce A, Polsky, Sarit, Pragnell, Marlon, Robiner, William N, Rosas, Sylvia E, Senior, Peter, Tuttle, Katherine R, Umpierrez, Guillermo E, Wallia, Amisha, Weinstock, Ruth S, Wu, Chunyi, Mauer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumin Allopurinol Allopurinol - adverse effects Allopurinol - therapeutic use Blood pressure Creatinine Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetic Nephropathies - prevention & control Double-Blind Method Drug dosages Enzyme Inhibitors - adverse effects Enzyme Inhibitors - therapeutic use Excretion Female General & Internal Medicine Glomerular filtration rate Glomerular Filtration Rate - drug effects Hemoglobin Humans International organizations Intervention Kidney diseases Life Sciences & Biomedicine Male Medicine, General & Internal Middle Aged Renin-Angiotensin System Science & Technology Statistical methods Treatment Failure Uric acid Uric Acid - blood Xanthine Oxidase - antagonists & inhibitors
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Zusammenfassung:	In a double-blind trial, patients with type 1 diabetes and early-to-moderate diabetic kidney disease were randomly assigned to receive allopurinol, which may slow the decline in the glomerular filtration rate, or placebo. There were no clinically meaningful benefits of serum urate reduction on kidney outcomes with allopurinol therapy.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1916624