Synthesis and antioxidant properties of some new thiazolyl coumarin derivatives
A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesi...
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| Veröffentlicht in: | Green chemistry letters and reviews 2020-04, Vol.13 (2), p.155-163 |
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| creator | Bensalah, Donia Mnasri, Aziza Chakchouk-Mtibaa, A. Mansour, Lamjed Mellouli, L. Hamdi, Naceur |
| description | A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR,
1
H NMR,
13
C NMR). Further, all the compounds were screened for their antioxidant activities. |
| doi_str_mv | 10.1080/17518253.2020.1762935 |
| format | Article |
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1
H NMR,
13
C NMR). Further, all the compounds were screened for their antioxidant activities.</description><identifier>ISSN: 1751-8253</identifier><identifier>EISSN: 1751-7192</identifier><identifier>DOI: 10.1080/17518253.2020.1762935</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis</publisher><subject>3-acetyl-4-hydroxycoumarin ; Acetic acid ; Ammonium ; Ammonium acetate ; Antioxidants ; Atom economy ; biological activities ; Chemical synthesis ; Coumarin ; Derivatives ; multicomponent reactions ; NMR ; Nuclear magnetic resonance ; Optimization ; Thiourea</subject><ispartof>Green chemistry letters and reviews, 2020-04, Vol.13 (2), p.155-163</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-b2fb450eee30906cc2192f6c0557b3799fda9f516d9b1af4085e014956c6ad633</citedby><cites>FETCH-LOGICAL-c451t-b2fb450eee30906cc2192f6c0557b3799fda9f516d9b1af4085e014956c6ad633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/17518253.2020.1762935$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/17518253.2020.1762935$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2102,27502,27924,27925,59143,59144</link.rule.ids></links><search><creatorcontrib>Bensalah, Donia</creatorcontrib><creatorcontrib>Mnasri, Aziza</creatorcontrib><creatorcontrib>Chakchouk-Mtibaa, A.</creatorcontrib><creatorcontrib>Mansour, Lamjed</creatorcontrib><creatorcontrib>Mellouli, L.</creatorcontrib><creatorcontrib>Hamdi, Naceur</creatorcontrib><title>Synthesis and antioxidant properties of some new thiazolyl coumarin derivatives</title><title>Green chemistry letters and reviews</title><description>A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR,
1
H NMR,
13
C NMR). 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The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR,
1
H NMR,
13
C NMR). Further, all the compounds were screened for their antioxidant activities.</abstract><cop>Abingdon</cop><pub>Taylor & Francis</pub><doi>10.1080/17518253.2020.1762935</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3-acetyl-4-hydroxycoumarin Acetic acid Ammonium Ammonium acetate Antioxidants Atom economy biological activities Chemical synthesis Coumarin Derivatives multicomponent reactions NMR Nuclear magnetic resonance Optimization Thiourea |
| title | Synthesis and antioxidant properties of some new thiazolyl coumarin derivatives |
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