Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature
Background Breast cancer patients may experience an increased chance of survival with adjuvant chemotherapy. However dermatologic adverse effects can cause major discomfort due to physical or cosmetic problems. This study aims to describe dermatologic complications in breast cancer patients during c...
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| Veröffentlicht in: | International journal of dermatology 2020-07, Vol.59 (7), p.822-828 |
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| container_title | International journal of dermatology |
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| creator | Alizadeh, Narges Mirpour, Seyyed Hossein Darjani, Abbas Rafiei, Rana Rafiei, Elahe Mohammadhoseini, Maryam |
| description | Background
Breast cancer patients may experience an increased chance of survival with adjuvant chemotherapy. However dermatologic adverse effects can cause major discomfort due to physical or cosmetic problems. This study aims to describe dermatologic complications in breast cancer patients during chemotherapy.
Methods
This longitudinal prospective observational study included data on women with non‐metastatic breast cancer whom were treated with AC‐T protocol (anthracycline, cyclophosphamide, and taxane) adjuvant chemotherapy and consecutively enrolled during two years. The study was performed in an educational and tertiary referral center. The patients’ information including age, body mass index (BMI), past medical history, and different dermatologic complications were collected for all participants.
Results
Of 190 enrolled women, all patients experienced alopecia, which occurred in 131 patients (68.9%) after the first cycle. Skin, mucosal, and nail involvement were respectively seen in 46 (24.2%), 51 (26.8%), and 86 (45.2%) cases. Cutaneous complications were observed mainly between the third and sixth chemotherapy cycles. Palmoplantar erythema and palmoplantar dysesthesia were the most common cutaneous complications. Dermatologic adverse effects were significantly more frequent in the patients with an underlying disease.
Conclusion
These findings suggest that dermatologic adverse effects of adjuvant chemotherapy are common and could be induced by all components of AC‐T regimen. These complications should be skillfully managed to increase patients’ comfort. |
| doi_str_mv | 10.1111/ijd.14916 |
| format | Article |
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Breast cancer patients may experience an increased chance of survival with adjuvant chemotherapy. However dermatologic adverse effects can cause major discomfort due to physical or cosmetic problems. This study aims to describe dermatologic complications in breast cancer patients during chemotherapy.
Methods
This longitudinal prospective observational study included data on women with non‐metastatic breast cancer whom were treated with AC‐T protocol (anthracycline, cyclophosphamide, and taxane) adjuvant chemotherapy and consecutively enrolled during two years. The study was performed in an educational and tertiary referral center. The patients’ information including age, body mass index (BMI), past medical history, and different dermatologic complications were collected for all participants.
Results
Of 190 enrolled women, all patients experienced alopecia, which occurred in 131 patients (68.9%) after the first cycle. Skin, mucosal, and nail involvement were respectively seen in 46 (24.2%), 51 (26.8%), and 86 (45.2%) cases. Cutaneous complications were observed mainly between the third and sixth chemotherapy cycles. Palmoplantar erythema and palmoplantar dysesthesia were the most common cutaneous complications. Dermatologic adverse effects were significantly more frequent in the patients with an underlying disease.
Conclusion
These findings suggest that dermatologic adverse effects of adjuvant chemotherapy are common and could be induced by all components of AC‐T regimen. These complications should be skillfully managed to increase patients’ comfort.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.14916</identifier><identifier>PMID: 32406107</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - drug therapy ; Adult ; Aged ; Aged, 80 and over ; Alopecia ; Alopecia - chemically induced ; Anthracycline ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Body mass ; Body Mass Index ; Body size ; Breast cancer ; Breast Neoplasms - drug therapy ; Chemotherapy ; Chemotherapy, Adjuvant - adverse effects ; Complications ; Cyclophosphamide ; Cyclophosphamide - administration & dosage ; Cyclophosphamide - adverse effects ; Docetaxel - administration & dosage ; Docetaxel - adverse effects ; Doxorubicin - administration & dosage ; Doxorubicin - adverse effects ; Erythema ; Female ; Hand-Foot Syndrome - etiology ; Humans ; Hyperpigmentation - chemically induced ; Literature reviews ; Longitudinal Studies ; Metastases ; Middle Aged ; Mucosa ; Mucositis - chemically induced ; Nail Diseases - chemically induced ; Observational studies ; Prospective Studies ; Review Literature as Topic ; Side effects ; Skin Diseases - chemically induced ; Taxanes</subject><ispartof>International journal of dermatology, 2020-07, Vol.59 (7), p.822-828</ispartof><rights>2020</rights><rights>2020 the International Society of Dermatology.</rights><rights>International Journal of Dermatology © 2020 International Society of Dermatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-476bff73e8d23afb10c5fbd1582f0f0084e4490b0d59b62015f07416edf285da3</citedby><cites>FETCH-LOGICAL-c3536-476bff73e8d23afb10c5fbd1582f0f0084e4490b0d59b62015f07416edf285da3</cites><orcidid>0000-0001-6599-0058 ; 0000-0002-7860-5232 ; 0000-0003-0850-488X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.14916$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.14916$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32406107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alizadeh, Narges</creatorcontrib><creatorcontrib>Mirpour, Seyyed Hossein</creatorcontrib><creatorcontrib>Darjani, Abbas</creatorcontrib><creatorcontrib>Rafiei, Rana</creatorcontrib><creatorcontrib>Rafiei, Elahe</creatorcontrib><creatorcontrib>Mohammadhoseini, Maryam</creatorcontrib><title>Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Breast cancer patients may experience an increased chance of survival with adjuvant chemotherapy. However dermatologic adverse effects can cause major discomfort due to physical or cosmetic problems. This study aims to describe dermatologic complications in breast cancer patients during chemotherapy.
Methods
This longitudinal prospective observational study included data on women with non‐metastatic breast cancer whom were treated with AC‐T protocol (anthracycline, cyclophosphamide, and taxane) adjuvant chemotherapy and consecutively enrolled during two years. The study was performed in an educational and tertiary referral center. The patients’ information including age, body mass index (BMI), past medical history, and different dermatologic complications were collected for all participants.
Results
Of 190 enrolled women, all patients experienced alopecia, which occurred in 131 patients (68.9%) after the first cycle. Skin, mucosal, and nail involvement were respectively seen in 46 (24.2%), 51 (26.8%), and 86 (45.2%) cases. Cutaneous complications were observed mainly between the third and sixth chemotherapy cycles. Palmoplantar erythema and palmoplantar dysesthesia were the most common cutaneous complications. Dermatologic adverse effects were significantly more frequent in the patients with an underlying disease.
Conclusion
These findings suggest that dermatologic adverse effects of adjuvant chemotherapy are common and could be induced by all components of AC‐T regimen. These complications should be skillfully managed to increase patients’ comfort.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alopecia</subject><subject>Alopecia - chemically induced</subject><subject>Anthracycline</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Complications</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Docetaxel - administration & dosage</subject><subject>Docetaxel - adverse effects</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - adverse effects</subject><subject>Erythema</subject><subject>Female</subject><subject>Hand-Foot Syndrome - etiology</subject><subject>Humans</subject><subject>Hyperpigmentation - chemically induced</subject><subject>Literature reviews</subject><subject>Longitudinal Studies</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Mucositis - chemically induced</subject><subject>Nail Diseases - chemically induced</subject><subject>Observational studies</subject><subject>Prospective Studies</subject><subject>Review Literature as Topic</subject><subject>Side effects</subject><subject>Skin Diseases - chemically induced</subject><subject>Taxanes</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9OAjEQhxujEUQPvoBp4snDQrvtll1vBvyDIfGi5013O4WShWLbhfACPrdF0Ju9TJr55svMD6FrSvo0voFZqD7lBRUnqEuZyBIuWHqKuoRQmhQkKzrowvtF_LKU8nPUYSkngpJhF32NwS1lsI2dmRpLtQHnAYPWUAePrcaVA-kDruWqBofrOSxtmIOT6909lrixq5kJrTIr2eC1s34d58wGsK08uI0Mxu47PiI7vDVhHmccbAxs9-7GhGgKrYNLdKZl4-HqWHvo4-nxffSSTN-eJ6OHaVKzjImED0Wl9ZBBrlImdUVJnelK0SxPNdGE5Bw4L0hFVFZUIiU002TIqQCl0zxTkvXQ7cEbd_1swYdyYVsXV_RlyqMmJiTySN0dqDpe5B3ocu3MUrpdSUm5T7yMiZc_iUf25mhsqyWoP_I34ggMDsDWNLD731ROXscH5Td99o0C</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Alizadeh, Narges</creator><creator>Mirpour, Seyyed Hossein</creator><creator>Darjani, Abbas</creator><creator>Rafiei, Rana</creator><creator>Rafiei, Elahe</creator><creator>Mohammadhoseini, Maryam</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0001-6599-0058</orcidid><orcidid>https://orcid.org/0000-0002-7860-5232</orcidid><orcidid>https://orcid.org/0000-0003-0850-488X</orcidid></search><sort><creationdate>202007</creationdate><title>Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature</title><author>Alizadeh, Narges ; Mirpour, Seyyed Hossein ; Darjani, Abbas ; Rafiei, Rana ; Rafiei, Elahe ; Mohammadhoseini, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-476bff73e8d23afb10c5fbd1582f0f0084e4490b0d59b62015f07416edf285da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alopecia</topic><topic>Alopecia - chemically induced</topic><topic>Anthracycline</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant - adverse effects</topic><topic>Complications</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Docetaxel - administration & dosage</topic><topic>Docetaxel - adverse effects</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - adverse effects</topic><topic>Erythema</topic><topic>Female</topic><topic>Hand-Foot Syndrome - etiology</topic><topic>Humans</topic><topic>Hyperpigmentation - chemically induced</topic><topic>Literature reviews</topic><topic>Longitudinal Studies</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Mucositis - chemically induced</topic><topic>Nail Diseases - chemically induced</topic><topic>Observational studies</topic><topic>Prospective Studies</topic><topic>Review Literature as Topic</topic><topic>Side effects</topic><topic>Skin Diseases - chemically induced</topic><topic>Taxanes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alizadeh, Narges</creatorcontrib><creatorcontrib>Mirpour, Seyyed Hossein</creatorcontrib><creatorcontrib>Darjani, Abbas</creatorcontrib><creatorcontrib>Rafiei, Rana</creatorcontrib><creatorcontrib>Rafiei, Elahe</creatorcontrib><creatorcontrib>Mohammadhoseini, Maryam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alizadeh, Narges</au><au>Mirpour, Seyyed Hossein</au><au>Darjani, Abbas</au><au>Rafiei, Rana</au><au>Rafiei, Elahe</au><au>Mohammadhoseini, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>59</volume><issue>7</issue><spage>822</spage><epage>828</epage><pages>822-828</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Breast cancer patients may experience an increased chance of survival with adjuvant chemotherapy. However dermatologic adverse effects can cause major discomfort due to physical or cosmetic problems. This study aims to describe dermatologic complications in breast cancer patients during chemotherapy.
Methods
This longitudinal prospective observational study included data on women with non‐metastatic breast cancer whom were treated with AC‐T protocol (anthracycline, cyclophosphamide, and taxane) adjuvant chemotherapy and consecutively enrolled during two years. The study was performed in an educational and tertiary referral center. The patients’ information including age, body mass index (BMI), past medical history, and different dermatologic complications were collected for all participants.
Results
Of 190 enrolled women, all patients experienced alopecia, which occurred in 131 patients (68.9%) after the first cycle. Skin, mucosal, and nail involvement were respectively seen in 46 (24.2%), 51 (26.8%), and 86 (45.2%) cases. Cutaneous complications were observed mainly between the third and sixth chemotherapy cycles. Palmoplantar erythema and palmoplantar dysesthesia were the most common cutaneous complications. Dermatologic adverse effects were significantly more frequent in the patients with an underlying disease.
Conclusion
These findings suggest that dermatologic adverse effects of adjuvant chemotherapy are common and could be induced by all components of AC‐T regimen. These complications should be skillfully managed to increase patients’ comfort.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32406107</pmid><doi>10.1111/ijd.14916</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6599-0058</orcidid><orcidid>https://orcid.org/0000-0002-7860-5232</orcidid><orcidid>https://orcid.org/0000-0003-0850-488X</orcidid></addata></record> |
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| subjects | Adenocarcinoma - drug therapy Adult Aged Aged, 80 and over Alopecia Alopecia - chemically induced Anthracycline Antineoplastic Combined Chemotherapy Protocols - adverse effects Body mass Body Mass Index Body size Breast cancer Breast Neoplasms - drug therapy Chemotherapy Chemotherapy, Adjuvant - adverse effects Complications Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Docetaxel - administration & dosage Docetaxel - adverse effects Doxorubicin - administration & dosage Doxorubicin - adverse effects Erythema Female Hand-Foot Syndrome - etiology Humans Hyperpigmentation - chemically induced Literature reviews Longitudinal Studies Metastases Middle Aged Mucosa Mucositis - chemically induced Nail Diseases - chemically induced Observational studies Prospective Studies Review Literature as Topic Side effects Skin Diseases - chemically induced Taxanes |
| title | Dermatologic adverse effects of breast cancer chemotherapy: a longitudinal prospective observational study with a review of literature |
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