Ossification in atherosclerotic carotid arteries
Heterotopic ossification as newly formed bone in extraosseous tissue is an uncommon finding in atherosclerotic lesions. The exact mechanisms and development of bone formation in regard to late stage calcified atherosclerosis still remains under debate. We studied 400 autopsy carotid probes and 306 s...
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| Veröffentlicht in: | Clinical research in cardiology 2001-04, Vol.90 Suppl 3 (15), p.106-115 |
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| creator | Deneke, T Langner, K Grewe, P H Harrer, E Müller, K M |
| description | Heterotopic ossification as newly formed bone in extraosseous tissue is an uncommon finding in atherosclerotic lesions. The exact mechanisms and development of bone formation in regard to late stage calcified atherosclerosis still remains under debate.
We studied 400 autopsy carotid probes and 306 samples of atherosclerotic carotid endatherectomy. Radiographic analysis and classification of calcification was performed followed by light microscopy. In probes with detected ossifications further analysis using immunohistochemistry, scanning electron microscopy (SEM) and energy dispersive x-ray micro-analysis (EDX) including calcium mapping was performed.
Ossification in atherosclerotic carotid arteries was a finding in only a minority of samples (5%) and occurred at sites of large calcific deposits. Histomorphology of bone formation equaled skeletal bone showing osteoblastic cells, osteocytes included in osteoid matrix, bone marrow and osteolytic giant multinucleated cells. Closely related to newly formed bone zones of neovascularization were found. Development of ossification seemed to occur in five stages (lipidous plaque, fibrous cellular plaque, fibrous acellular plaque, calcified plaque and osteogenesis). The environment of sites of ossification was characterized by a varying texture of extracellular fibrous matrix, foam cells, smooth muscle cells, fibroblasts and calcified deposits.
Heterotopic ossifications of atherosclerotic plaques seem to be a specific differentiation of fibrous plaques. Components of atherosclerotic lesions like vascular wall cells, neovessels and matrix structures seem to be involved in the process of transformation to mature bone tissue. |
| doi_str_mv | 10.1007/s003920170031 |
| format | Article |
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We studied 400 autopsy carotid probes and 306 samples of atherosclerotic carotid endatherectomy. Radiographic analysis and classification of calcification was performed followed by light microscopy. In probes with detected ossifications further analysis using immunohistochemistry, scanning electron microscopy (SEM) and energy dispersive x-ray micro-analysis (EDX) including calcium mapping was performed.
Ossification in atherosclerotic carotid arteries was a finding in only a minority of samples (5%) and occurred at sites of large calcific deposits. Histomorphology of bone formation equaled skeletal bone showing osteoblastic cells, osteocytes included in osteoid matrix, bone marrow and osteolytic giant multinucleated cells. Closely related to newly formed bone zones of neovascularization were found. Development of ossification seemed to occur in five stages (lipidous plaque, fibrous cellular plaque, fibrous acellular plaque, calcified plaque and osteogenesis). The environment of sites of ossification was characterized by a varying texture of extracellular fibrous matrix, foam cells, smooth muscle cells, fibroblasts and calcified deposits.
Heterotopic ossifications of atherosclerotic plaques seem to be a specific differentiation of fibrous plaques. Components of atherosclerotic lesions like vascular wall cells, neovessels and matrix structures seem to be involved in the process of transformation to mature bone tissue.</description><identifier>ISSN: 0300-5860</identifier><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1435-1285</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s003920170031</identifier><identifier>PMID: 11374022</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Arteries ; Arteriosclerosis ; Arteriosclerosis - pathology ; Atherosclerosis ; Autopsies ; Autopsy ; Biomedical materials ; Bone growth ; Bone marrow ; Bone matrix ; Calcification ; Calcification (ectopic) ; Calcinosis - pathology ; Calcium ; Carotid arteries ; Carotid Arteries - pathology ; Carotid artery ; Carotid Stenosis - pathology ; Culture Techniques ; Deposits ; Differentiation ; Energy ; Fibroblasts ; Humans ; Immunohistochemistry ; Lesions ; Light microscopy ; Mapping ; Microscopy ; Microscopy, Electron, Scanning ; Muscles ; Optical microscopy ; Ossification ; Ossification (ectopic) ; Ossification, Heterotopic - pathology ; Osteoblasts ; Osteocytes ; Osteogenesis ; Osteoid ; Osteolysis ; Plaques ; Probes ; Scanning electron microscopy ; Smooth muscle ; Vascularization</subject><ispartof>Clinical research in cardiology, 2001-04, Vol.90 Suppl 3 (15), p.106-115</ispartof><rights>Steinkopff Verlag 2001.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c265t-c211e35eadd9c89827b4c49fb5dde2d4cb3f4da6fd30e8e6353032a4025c9a523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11374022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deneke, T</creatorcontrib><creatorcontrib>Langner, K</creatorcontrib><creatorcontrib>Grewe, P H</creatorcontrib><creatorcontrib>Harrer, E</creatorcontrib><creatorcontrib>Müller, K M</creatorcontrib><title>Ossification in atherosclerotic carotid arteries</title><title>Clinical research in cardiology</title><addtitle>Z Kardiol</addtitle><description>Heterotopic ossification as newly formed bone in extraosseous tissue is an uncommon finding in atherosclerotic lesions. The exact mechanisms and development of bone formation in regard to late stage calcified atherosclerosis still remains under debate.
We studied 400 autopsy carotid probes and 306 samples of atherosclerotic carotid endatherectomy. Radiographic analysis and classification of calcification was performed followed by light microscopy. In probes with detected ossifications further analysis using immunohistochemistry, scanning electron microscopy (SEM) and energy dispersive x-ray micro-analysis (EDX) including calcium mapping was performed.
Ossification in atherosclerotic carotid arteries was a finding in only a minority of samples (5%) and occurred at sites of large calcific deposits. Histomorphology of bone formation equaled skeletal bone showing osteoblastic cells, osteocytes included in osteoid matrix, bone marrow and osteolytic giant multinucleated cells. Closely related to newly formed bone zones of neovascularization were found. Development of ossification seemed to occur in five stages (lipidous plaque, fibrous cellular plaque, fibrous acellular plaque, calcified plaque and osteogenesis). The environment of sites of ossification was characterized by a varying texture of extracellular fibrous matrix, foam cells, smooth muscle cells, fibroblasts and calcified deposits.
Heterotopic ossifications of atherosclerotic plaques seem to be a specific differentiation of fibrous plaques. Components of atherosclerotic lesions like vascular wall cells, neovessels and matrix structures seem to be involved in the process of transformation to mature bone tissue.</description><subject>Arteries</subject><subject>Arteriosclerosis</subject><subject>Arteriosclerosis - pathology</subject><subject>Atherosclerosis</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone matrix</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcinosis - pathology</subject><subject>Calcium</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid artery</subject><subject>Carotid Stenosis - pathology</subject><subject>Culture Techniques</subject><subject>Deposits</subject><subject>Differentiation</subject><subject>Energy</subject><subject>Fibroblasts</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lesions</subject><subject>Light microscopy</subject><subject>Mapping</subject><subject>Microscopy</subject><subject>Microscopy, Electron, Scanning</subject><subject>Muscles</subject><subject>Optical microscopy</subject><subject>Ossification</subject><subject>Ossification (ectopic)</subject><subject>Ossification, Heterotopic - pathology</subject><subject>Osteoblasts</subject><subject>Osteocytes</subject><subject>Osteogenesis</subject><subject>Osteoid</subject><subject>Osteolysis</subject><subject>Plaques</subject><subject>Probes</subject><subject>Scanning electron microscopy</subject><subject>Smooth muscle</subject><subject>Vascularization</subject><issn>0300-5860</issn><issn>1861-0684</issn><issn>1435-1285</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90E1LAzEQBuAgiq3Vo1dZEMTL6kwm2ewepfgFhV70vGSTLKZsd2uyPfjvTWlB9OBl3svDMPMydolwhwDqPgJQxQFVSjxiUxQkc-SlPGZTIIBclgVM2FmMK0hKFXTKJoikBHA-ZbCM0bfe6NEPfeb7TI8fLgzRdGmO3mRG79JmOowueBfP2Umru-guDjlj70-Pb_OXfLF8fp0_LHLDCzmmiehIOm1tZcqq5KoRRlRtI6113ArTUCusLlpL4EpXkCQgrtNR0lRacpqxm_3eTRg-ty6O9dpH47pO927YxlpBWUiuygRv_4VIKAsk4CLR6z90NWxDn96ouUCpQCmUSeV7ZVIPMbi23gS_1uGrRqh3nde_Ok_-6rB126yd_dGHkukbfsh6GA</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Deneke, T</creator><creator>Langner, K</creator><creator>Grewe, P H</creator><creator>Harrer, E</creator><creator>Müller, K M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Ossification in atherosclerotic carotid arteries</title><author>Deneke, T ; Langner, K ; Grewe, P H ; Harrer, E ; Müller, K M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-c211e35eadd9c89827b4c49fb5dde2d4cb3f4da6fd30e8e6353032a4025c9a523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Arteries</topic><topic>Arteriosclerosis</topic><topic>Arteriosclerosis - pathology</topic><topic>Atherosclerosis</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone marrow</topic><topic>Bone matrix</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcinosis - pathology</topic><topic>Calcium</topic><topic>Carotid arteries</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid artery</topic><topic>Carotid Stenosis - pathology</topic><topic>Culture Techniques</topic><topic>Deposits</topic><topic>Differentiation</topic><topic>Energy</topic><topic>Fibroblasts</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lesions</topic><topic>Light microscopy</topic><topic>Mapping</topic><topic>Microscopy</topic><topic>Microscopy, Electron, Scanning</topic><topic>Muscles</topic><topic>Optical microscopy</topic><topic>Ossification</topic><topic>Ossification (ectopic)</topic><topic>Ossification, Heterotopic - pathology</topic><topic>Osteoblasts</topic><topic>Osteocytes</topic><topic>Osteogenesis</topic><topic>Osteoid</topic><topic>Osteolysis</topic><topic>Plaques</topic><topic>Probes</topic><topic>Scanning electron microscopy</topic><topic>Smooth muscle</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deneke, T</creatorcontrib><creatorcontrib>Langner, K</creatorcontrib><creatorcontrib>Grewe, P H</creatorcontrib><creatorcontrib>Harrer, E</creatorcontrib><creatorcontrib>Müller, K M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deneke, T</au><au>Langner, K</au><au>Grewe, P H</au><au>Harrer, E</au><au>Müller, K M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ossification in atherosclerotic carotid arteries</atitle><jtitle>Clinical research in cardiology</jtitle><addtitle>Z Kardiol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>90 Suppl 3</volume><issue>15</issue><spage>106</spage><epage>115</epage><pages>106-115</pages><issn>0300-5860</issn><issn>1861-0684</issn><eissn>1435-1285</eissn><eissn>1861-0692</eissn><abstract>Heterotopic ossification as newly formed bone in extraosseous tissue is an uncommon finding in atherosclerotic lesions. The exact mechanisms and development of bone formation in regard to late stage calcified atherosclerosis still remains under debate.
We studied 400 autopsy carotid probes and 306 samples of atherosclerotic carotid endatherectomy. Radiographic analysis and classification of calcification was performed followed by light microscopy. In probes with detected ossifications further analysis using immunohistochemistry, scanning electron microscopy (SEM) and energy dispersive x-ray micro-analysis (EDX) including calcium mapping was performed.
Ossification in atherosclerotic carotid arteries was a finding in only a minority of samples (5%) and occurred at sites of large calcific deposits. Histomorphology of bone formation equaled skeletal bone showing osteoblastic cells, osteocytes included in osteoid matrix, bone marrow and osteolytic giant multinucleated cells. Closely related to newly formed bone zones of neovascularization were found. Development of ossification seemed to occur in five stages (lipidous plaque, fibrous cellular plaque, fibrous acellular plaque, calcified plaque and osteogenesis). The environment of sites of ossification was characterized by a varying texture of extracellular fibrous matrix, foam cells, smooth muscle cells, fibroblasts and calcified deposits.
Heterotopic ossifications of atherosclerotic plaques seem to be a specific differentiation of fibrous plaques. Components of atherosclerotic lesions like vascular wall cells, neovessels and matrix structures seem to be involved in the process of transformation to mature bone tissue.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>11374022</pmid><doi>10.1007/s003920170031</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-5860 |
| ispartof | Clinical research in cardiology, 2001-04, Vol.90 Suppl 3 (15), p.106-115 |
| issn | 0300-5860 1861-0684 1435-1285 1861-0692 |
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| subjects | Arteries Arteriosclerosis Arteriosclerosis - pathology Atherosclerosis Autopsies Autopsy Biomedical materials Bone growth Bone marrow Bone matrix Calcification Calcification (ectopic) Calcinosis - pathology Calcium Carotid arteries Carotid Arteries - pathology Carotid artery Carotid Stenosis - pathology Culture Techniques Deposits Differentiation Energy Fibroblasts Humans Immunohistochemistry Lesions Light microscopy Mapping Microscopy Microscopy, Electron, Scanning Muscles Optical microscopy Ossification Ossification (ectopic) Ossification, Heterotopic - pathology Osteoblasts Osteocytes Osteogenesis Osteoid Osteolysis Plaques Probes Scanning electron microscopy Smooth muscle Vascularization |
| title | Ossification in atherosclerotic carotid arteries |
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