Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice
We examined changes in 5-hydroxytriptamine (5-HT, serotonin) neurons in pyrithiamine-induced thiamine deficiency in mice immunohistochemically. Extensive decreases in the densities of 5-HT-immunoreactive fibers were detected in the lateral septal nucleus, the thalamus, the medial mammillary nucleus,...
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| Veröffentlicht in: | Acta neuropathologica 1999-12, Vol.98 (6), p.614-621 |
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| creator | MATSUSHITA, H TAKEUCHI, Y KOSAKA, K FUSHIKI, S KAWATA, M SAWADA, T |
| description | We examined changes in 5-hydroxytriptamine (5-HT, serotonin) neurons in pyrithiamine-induced thiamine deficiency in mice immunohistochemically. Extensive decreases in the densities of 5-HT-immunoreactive fibers were detected in the lateral septal nucleus, the thalamus, the medial mammillary nucleus, the dorsal and the median raphe nuclei, the raphe obscurus nucleus, the tegmental area, the cerebellum and the vestibular nucleus, though only a small decrease was detected in the inferior colliculus. Most remarkably, degenerative winding fibers were detected between the deep mesencephalic nucleus and the ventral tegmental area. Increases in intensity of 5-HT immunoreactivity in the dorsal raphe nucleus and decreases in the number of 5-HT-immunoreactive cell bodies in the dorsal and the median raphe nuclei were detected. These results demonstrated the differential vulnerability of 5-HT neurons in thiamine-deficient mice. This is the first report to demonstrate changes in 5-HT neurons immunohistochemically throughout the brain of pyrithiamine-induced thiamine deficient mouse. |
| doi_str_mv | 10.1007/s004010051126 |
| format | Article |
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Extensive decreases in the densities of 5-HT-immunoreactive fibers were detected in the lateral septal nucleus, the thalamus, the medial mammillary nucleus, the dorsal and the median raphe nuclei, the raphe obscurus nucleus, the tegmental area, the cerebellum and the vestibular nucleus, though only a small decrease was detected in the inferior colliculus. Most remarkably, degenerative winding fibers were detected between the deep mesencephalic nucleus and the ventral tegmental area. Increases in intensity of 5-HT immunoreactivity in the dorsal raphe nucleus and decreases in the number of 5-HT-immunoreactive cell bodies in the dorsal and the median raphe nuclei were detected. These results demonstrated the differential vulnerability of 5-HT neurons in thiamine-deficient mice. This is the first report to demonstrate changes in 5-HT neurons immunohistochemically throughout the brain of pyrithiamine-induced thiamine deficient mouse.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010051126</identifier><identifier>PMID: 10603037</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antimetabolites - pharmacology ; Biological and medical sciences ; Brain - drug effects ; Brain - pathology ; Brain Chemistry - drug effects ; Cerebellum ; Dorsal raphe nucleus ; Fibers ; Immunoreactivity ; Inferior colliculus ; Male ; Medical sciences ; Metabolic diseases ; Mice ; Mice, Inbred ICR ; Neurons ; Neurons - drug effects ; Neurons - pathology ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Pyrithiamine ; Pyrithiamine - pharmacology ; Raphe nuclei ; Raphe Nuclei - drug effects ; Raphe Nuclei - pathology ; Serotonin ; Serotonin - metabolism ; Thalamus ; Thiamine ; Thiamine Deficiency - chemically induced ; Ventral tegmentum ; Vestibular nuclei ; Vestibular system ; Vitamin B</subject><ispartof>Acta neuropathologica, 1999-12, Vol.98 (6), p.614-621</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-79049ff6192c0d51272da0faf9959ed51b72e21b24c2c5595deb0546f8b3b85a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1185796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10603037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUSHITA, H</creatorcontrib><creatorcontrib>TAKEUCHI, Y</creatorcontrib><creatorcontrib>KOSAKA, K</creatorcontrib><creatorcontrib>FUSHIKI, S</creatorcontrib><creatorcontrib>KAWATA, M</creatorcontrib><creatorcontrib>SAWADA, T</creatorcontrib><title>Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>We examined changes in 5-hydroxytriptamine (5-HT, serotonin) neurons in pyrithiamine-induced thiamine deficiency in mice immunohistochemically. Extensive decreases in the densities of 5-HT-immunoreactive fibers were detected in the lateral septal nucleus, the thalamus, the medial mammillary nucleus, the dorsal and the median raphe nuclei, the raphe obscurus nucleus, the tegmental area, the cerebellum and the vestibular nucleus, though only a small decrease was detected in the inferior colliculus. Most remarkably, degenerative winding fibers were detected between the deep mesencephalic nucleus and the ventral tegmental area. Increases in intensity of 5-HT immunoreactivity in the dorsal raphe nucleus and decreases in the number of 5-HT-immunoreactive cell bodies in the dorsal and the median raphe nuclei were detected. These results demonstrated the differential vulnerability of 5-HT neurons in thiamine-deficient mice. This is the first report to demonstrate changes in 5-HT neurons immunohistochemically throughout the brain of pyrithiamine-induced thiamine deficient mouse.</description><subject>Animals</subject><subject>Antimetabolites - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Brain Chemistry - drug effects</subject><subject>Cerebellum</subject><subject>Dorsal raphe nucleus</subject><subject>Fibers</subject><subject>Immunoreactivity</subject><subject>Inferior colliculus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Pyrithiamine</subject><subject>Pyrithiamine - pharmacology</subject><subject>Raphe nuclei</subject><subject>Raphe Nuclei - drug effects</subject><subject>Raphe Nuclei - pathology</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Thalamus</subject><subject>Thiamine</subject><subject>Thiamine Deficiency - chemically induced</subject><subject>Ventral tegmentum</subject><subject>Vestibular nuclei</subject><subject>Vestibular system</subject><subject>Vitamin B</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkEtPwzAQhC0EoqVw5IoswTWwfiXNEVW8pEpc4BzZzrp11TrFTg799xha8Tjt7OjT7GoIuWRwywCquwQgISvFGC-PyJhJwQtQQhyTMQCwohScj8hZSqu88UqqUzJiUIIAUY2JmS11WGCiPtCEseu7gHHhLQ04xC58-_0SqYk6q87R7S76fun1xgcsfGgHiy3VduiR_tgtOm89hp5uvMVzcuL0OuHFYU7I--PD2-y5mL8-vczu54WVjPdFVYOsnStZzS20Kr_KWw1Ou7pWNWbDVBw5M1xabpWqVYsGlCzd1AgzVVpMyPU-dxu7jwFT36y6IYZ8suGSKVUJJnmmij1lY5dSRNdso9_ouGsYNF-NNv8azfzVIXUwG2z_0PsKM3BzAHSyeu2iDtanX45NVVWX4hMZVX0Z</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>MATSUSHITA, H</creator><creator>TAKEUCHI, Y</creator><creator>KOSAKA, K</creator><creator>FUSHIKI, S</creator><creator>KAWATA, M</creator><creator>SAWADA, T</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19991201</creationdate><title>Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice</title><author>MATSUSHITA, H ; TAKEUCHI, Y ; KOSAKA, K ; FUSHIKI, S ; KAWATA, M ; SAWADA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-79049ff6192c0d51272da0faf9959ed51b72e21b24c2c5595deb0546f8b3b85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antimetabolites - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Brain Chemistry - drug effects</topic><topic>Cerebellum</topic><topic>Dorsal raphe nucleus</topic><topic>Fibers</topic><topic>Immunoreactivity</topic><topic>Inferior colliculus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Pyrithiamine</topic><topic>Pyrithiamine - pharmacology</topic><topic>Raphe nuclei</topic><topic>Raphe Nuclei - drug effects</topic><topic>Raphe Nuclei - pathology</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Thalamus</topic><topic>Thiamine</topic><topic>Thiamine Deficiency - chemically induced</topic><topic>Ventral tegmentum</topic><topic>Vestibular nuclei</topic><topic>Vestibular system</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUSHITA, H</creatorcontrib><creatorcontrib>TAKEUCHI, Y</creatorcontrib><creatorcontrib>KOSAKA, K</creatorcontrib><creatorcontrib>FUSHIKI, S</creatorcontrib><creatorcontrib>KAWATA, M</creatorcontrib><creatorcontrib>SAWADA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUSHITA, H</au><au>TAKEUCHI, Y</au><au>KOSAKA, K</au><au>FUSHIKI, S</au><au>KAWATA, M</au><au>SAWADA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>98</volume><issue>6</issue><spage>614</spage><epage>621</epage><pages>614-621</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>We examined changes in 5-hydroxytriptamine (5-HT, serotonin) neurons in pyrithiamine-induced thiamine deficiency in mice immunohistochemically. Extensive decreases in the densities of 5-HT-immunoreactive fibers were detected in the lateral septal nucleus, the thalamus, the medial mammillary nucleus, the dorsal and the median raphe nuclei, the raphe obscurus nucleus, the tegmental area, the cerebellum and the vestibular nucleus, though only a small decrease was detected in the inferior colliculus. Most remarkably, degenerative winding fibers were detected between the deep mesencephalic nucleus and the ventral tegmental area. Increases in intensity of 5-HT immunoreactivity in the dorsal raphe nucleus and decreases in the number of 5-HT-immunoreactive cell bodies in the dorsal and the median raphe nuclei were detected. These results demonstrated the differential vulnerability of 5-HT neurons in thiamine-deficient mice. This is the first report to demonstrate changes in 5-HT neurons immunohistochemically throughout the brain of pyrithiamine-induced thiamine deficient mouse.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10603037</pmid><doi>10.1007/s004010051126</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antimetabolites - pharmacology Biological and medical sciences Brain - drug effects Brain - pathology Brain Chemistry - drug effects Cerebellum Dorsal raphe nucleus Fibers Immunoreactivity Inferior colliculus Male Medical sciences Metabolic diseases Mice Mice, Inbred ICR Neurons Neurons - drug effects Neurons - pathology Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Pyrithiamine Pyrithiamine - pharmacology Raphe nuclei Raphe Nuclei - drug effects Raphe Nuclei - pathology Serotonin Serotonin - metabolism Thalamus Thiamine Thiamine Deficiency - chemically induced Ventral tegmentum Vestibular nuclei Vestibular system Vitamin B |
| title | Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice |
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