Cytochrome C oxidase deficiency in the muscle of patients with zidovudine myopathy is segmental and affects both mitochondrial DNA and nuclear DNA-encoded subunits

Zidovudine (AZT) can induce a mitochondrial disorder associated with mitochondrial (mt) DNA depletion affecting skeletal muscle, heart, and liver. Zidovudine myopathy is characterized by ragged-red fibers and partial cytochrome c oxidase (COX) deficiency. We evaluated at a single fiber level the exp...

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Veröffentlicht in:	Acta neuropathologica 2000-07, Vol.100 (1), p.82-86
Hauptverfasser:	YERROUM, M, PHAM-DANG, C, AUTHIER, F.-J, MONNET, I, GHERARDI, R, CHARIOT, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antiretroviral drugs Biological and medical sciences Cardiac muscle Chromosomes - drug effects Chromosomes - genetics Cytochrome Cytochrome-c oxidase Cytochrome-c Oxidase Deficiency Deoxyribonucleic acid DNA DNA, Mitochondrial - drug effects DNA, Mitochondrial - genetics Electron Transport Complex IV - genetics Epilepsy HIV Human immunodeficiency virus Human viral diseases Humans Infectious diseases Medical sciences Mitochondrial DNA Mitochondrial Myopathies - chemically induced Mitochondrial Myopathies - metabolism Mitochondrial Myopathies - pathology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Diseases - chemically induced Muscular Diseases - metabolism Muscular Diseases - pathology Myoclonus Myopathy Skeletal muscle Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zidovudine Zidovudine - adverse effects
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