The pathological role of ferroptosis in ischemia/reperfusion-related injury
Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid pe...
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| creator | Yan, Hong-Fa Tuo, Qing-Zhang Yin, Qiao-Zhi Lei, Peng |
| description | Ischemia/reperfusion (I/R) is a pathological process that occurs in
numerous organs throughout the human body, and it is frequently
associated with severe cellular damage and death. Recently it has
emerged that ferroptosis, a new form of regulated cell death that is
caused by iron-dependent lipid peroxidation, plays a significantly
detrimental role in many I/R models. In this review, we aim to revise
the pathological process of I/R and then explore the molecular
pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role
that ferroptosis plays in I/R, providing evidence to support the
targeting of ferroptosis in the I/R pathway may present as a
therapeutic intervention to alleviate ischemia/reperfusion injury (IRI)
associated cell damage and death. |
| doi_str_mv | 10.24272/j.issn.2095-8137.2020.042 |
| format | Article |
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numerous organs throughout the human body, and it is frequently
associated with severe cellular damage and death. Recently it has
emerged that ferroptosis, a new form of regulated cell death that is
caused by iron-dependent lipid peroxidation, plays a significantly
detrimental role in many I/R models. In this review, we aim to revise
the pathological process of I/R and then explore the molecular
pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role
that ferroptosis plays in I/R, providing evidence to support the
targeting of ferroptosis in the I/R pathway may present as a
therapeutic intervention to alleviate ischemia/reperfusion injury (IRI)
associated cell damage and death.</description><identifier>ISSN: 2095-8137</identifier><identifier>ISSN: 0254-5853</identifier><identifier>DOI: 10.24272/j.issn.2095-8137.2020.042</identifier><identifier>PMID: 32314558</identifier><language>eng</language><publisher>China: Kunming Institute of Zoology, Chinese Academy of Sciences</publisher><subject>Antioxidants ; Apoptosis ; Body organs ; Cell death ; Damage ; Disease ; Enzymes ; Ferroptosis ; Iron ; Ischemia ; Ischemia/reperfusion ; Lipid peroxidation ; Lipids ; Metabolism ; Mortality ; Organs ; Oxidation ; Pathogenesis ; Pathology ; Peroxidation ; Reactive oxygen species ; Recovery (Medical) ; Reperfusion ; Reviews</subject><ispartof>Dōngwùxué yánjiū, 2020-05, Vol.41 (3), p.220-230</ispartof><rights>Copyright 2020 - Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences May 2020</rights><rights>Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences 2020 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b559t-584765a778d974b0bea78acebe788692c8c3013eab9ca5e95bcf0c9e6717e10e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32314558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Hong-Fa</creatorcontrib><creatorcontrib>Tuo, Qing-Zhang</creatorcontrib><creatorcontrib>Yin, Qiao-Zhi</creatorcontrib><creatorcontrib>Lei, Peng</creatorcontrib><creatorcontrib>Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, China</creatorcontrib><creatorcontrib>Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Center for Biotherapy, Chengdu, Sichuan 610041, China</creatorcontrib><title>The pathological role of ferroptosis in ischemia/reperfusion-related injury</title><title>Dōngwùxué yánjiū</title><addtitle>Zool Res</addtitle><description>Ischemia/reperfusion (I/R) is a pathological process that occurs in
numerous organs throughout the human body, and it is frequently
associated with severe cellular damage and death. Recently it has
emerged that ferroptosis, a new form of regulated cell death that is
caused by iron-dependent lipid peroxidation, plays a significantly
detrimental role in many I/R models. In this review, we aim to revise
the pathological process of I/R and then explore the molecular
pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role
that ferroptosis plays in I/R, providing evidence to support the
targeting of ferroptosis in the I/R pathway may present as a
therapeutic intervention to alleviate ischemia/reperfusion injury (IRI)
associated cell damage and death.</description><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Body organs</subject><subject>Cell death</subject><subject>Damage</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Ferroptosis</subject><subject>Iron</subject><subject>Ischemia</subject><subject>Ischemia/reperfusion</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Organs</subject><subject>Oxidation</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Peroxidation</subject><subject>Reactive oxygen species</subject><subject>Recovery (Medical)</subject><subject>Reperfusion</subject><subject>Reviews</subject><issn>2095-8137</issn><issn>0254-5853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1r3DAQhnVoSUKSv1BMe-nFjj4sS-qhUELzQQK5JGchacdZLVrLlexC8usrZ5OlCQgkZp4Z9PIg9JXghrZU0LNN43MeGooVryVhorwobnBLP6GjffEQnebsLebljSnpDtAho4y0nMsjdHO_hmo00zqG-OidCVWKAarYVz2kFMcpZp8rP1Q-uzVsvTlLMELq5-zjUCcIZoJV6W_m9HSCPvcmZDh9vY_Rw8Xv-_Or-vbu8vr8121tOVdTzWUrOm6EkCslWostGCGNAwtCyk5RJx3DhIGxyhkOilvXY6egE0QAwcCO0c_d3nG2W1g5GKZkgh6T35r0pKPx-n1n8Gv9GP9qscTuVFnw_XVBin9myJPelngQghkgzllTphhuCe5YQb99QDdxTkOJp2lLWikIlrhQP3aUSzHnBP3-MwTrF1V6oxdVerGiFyt6UaWLqjL85f84-9E3SQVodoD1MfgB9oRL3ui34nMqh2JMBfsHpFimYA</recordid><startdate>20200518</startdate><enddate>20200518</enddate><creator>Yan, Hong-Fa</creator><creator>Tuo, Qing-Zhang</creator><creator>Yin, Qiao-Zhi</creator><creator>Lei, 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pathological role of ferroptosis in ischemia/reperfusion-related injury</title><author>Yan, Hong-Fa ; Tuo, Qing-Zhang ; Yin, Qiao-Zhi ; Lei, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b559t-584765a778d974b0bea78acebe788692c8c3013eab9ca5e95bcf0c9e6717e10e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Body organs</topic><topic>Cell death</topic><topic>Damage</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Ferroptosis</topic><topic>Iron</topic><topic>Ischemia</topic><topic>Ischemia/reperfusion</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Organs</topic><topic>Oxidation</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Peroxidation</topic><topic>Reactive oxygen species</topic><topic>Recovery 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West China Hospital, Sichuan University, and Collaborative Center for Biotherapy, Chengdu, Sichuan 610041, China</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pathological role of ferroptosis in ischemia/reperfusion-related injury</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zool Res</addtitle><date>2020-05-18</date><risdate>2020</risdate><volume>41</volume><issue>3</issue><spage>220</spage><epage>230</epage><pages>220-230</pages><issn>2095-8137</issn><issn>0254-5853</issn><abstract>Ischemia/reperfusion (I/R) is a pathological process that occurs in
numerous organs throughout the human body, and it is frequently
associated with severe cellular damage and death. Recently it has
emerged that ferroptosis, a new form of regulated cell death that is
caused by iron-dependent lipid peroxidation, plays a significantly
detrimental role in many I/R models. In this review, we aim to revise
the pathological process of I/R and then explore the molecular
pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role
that ferroptosis plays in I/R, providing evidence to support the
targeting of ferroptosis in the I/R pathway may present as a
therapeutic intervention to alleviate ischemia/reperfusion injury (IRI)
associated cell damage and death.</abstract><cop>China</cop><pub>Kunming Institute of Zoology, Chinese Academy of Sciences</pub><pmid>32314558</pmid><doi>10.24272/j.issn.2095-8137.2020.042</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-8137 |
| ispartof | Dōngwùxué yánjiū, 2020-05, Vol.41 (3), p.220-230 |
| issn | 2095-8137 0254-5853 |
| language | eng |
| recordid | cdi_proquest_journals_2414871080 |
| source | Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antioxidants Apoptosis Body organs Cell death Damage Disease Enzymes Ferroptosis Iron Ischemia Ischemia/reperfusion Lipid peroxidation Lipids Metabolism Mortality Organs Oxidation Pathogenesis Pathology Peroxidation Reactive oxygen species Recovery (Medical) Reperfusion Reviews |
| title | The pathological role of ferroptosis in ischemia/reperfusion-related injury |
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