Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review
BackgroundPancreaticopleural fistula (PPF) is a very rare and critical complication of pancreatitis in children. The majority of publications relevant to PPF are case reports. No pooled analyses of PPF cases are available. Little is known about the pathogenesis and optimal therapeutic schedule. The...
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| description | BackgroundPancreaticopleural fistula (PPF) is a very rare and critical complication of pancreatitis in children. The majority of publications relevant to PPF are case reports. No pooled analyses of PPF cases are available. Little is known about the pathogenesis and optimal therapeutic schedule. The purpose of this study was to identify the pathogenesis and optimal therapeutic schedule of PPF in children.Case presentationThe patient was a 13-year-old girl who suffered from intermittent chest tightness and dyspnea for more than 3months; she was found to have chronic pancreatitis complicated by PPF. The genetic screening revealed SPINK1 mutation. She was treated with endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic retrograde pancreatic drainage (ERPD); her symptoms improved dramatically after the procedures.ConclusionsPPF is a rare pancreatic complication in children and causes significant pulmonary symptoms that can be misdiagnosed frequently. PPF in children is mainly associated with chronic pancreatitis (CP); therefore, we highlight the importance of genetic testing. Endoscopic treatment is recommended when conservative treatment is ineffective. |
| doi_str_mv | 10.1186/s12887-020-02174-x |
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The majority of publications relevant to PPF are case reports. No pooled analyses of PPF cases are available. Little is known about the pathogenesis and optimal therapeutic schedule. The purpose of this study was to identify the pathogenesis and optimal therapeutic schedule of PPF in children.Case presentationThe patient was a 13-year-old girl who suffered from intermittent chest tightness and dyspnea for more than 3months; she was found to have chronic pancreatitis complicated by PPF. The genetic screening revealed SPINK1 mutation. She was treated with endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic retrograde pancreatic drainage (ERPD); her symptoms improved dramatically after the procedures.ConclusionsPPF is a rare pancreatic complication in children and causes significant pulmonary symptoms that can be misdiagnosed frequently. PPF in children is mainly associated with chronic pancreatitis (CP); therefore, we highlight the importance of genetic testing. Endoscopic treatment is recommended when conservative treatment is ineffective.</description><identifier>ISSN: 1471-2431</identifier><identifier>EISSN: 1471-2431</identifier><identifier>DOI: 10.1186/s12887-020-02174-x</identifier><identifier>PMID: 32493299</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Abdomen ; Adolescent ; Case Report ; Case reports ; Child ; Cholangiopancreatography, Endoscopic Retrograde ; Chronic pancreatitis ; Cysts ; Dyspnea ; Endoscopy ; Female ; Fistula ; Fistulas ; Genetic aspects ; Genetic testing ; Health aspects ; Hospitalization ; Humans ; Life Sciences & Biomedicine ; Medical imaging ; Mutation ; Pain ; Pancreas ; Pancreatic Fistula - diagnosis ; Pancreatic Fistula - etiology ; Pancreaticopleural fistula ; Pancreatitis ; Pancreatitis, Chronic - complications ; Pancreatitis, Chronic - diagnosis ; Pancreatitis, Chronic - therapy ; Pathogenesis ; Pediatrics ; Pleural Diseases - diagnosis ; Pleural Diseases - etiology ; Pleural effusion ; Science & Technology ; Surgery ; Teenage girls ; Trypsin Inhibitor, Kazal Pancreatic</subject><ispartof>BMC pediatrics, 2020-06, Vol.20 (1), p.274-274, Article 274</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000540034100008</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c594t-593868e39255322ad8b3b2865a232d2e938e6242e4bae3a44b33af2dd76ab9f03</citedby><cites>FETCH-LOGICAL-c594t-593868e39255322ad8b3b2865a232d2e938e6242e4bae3a44b33af2dd76ab9f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268358/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268358/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,28252,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32493299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jia-yu</creatorcontrib><creatorcontrib>Deng, Zhao-hui</creatorcontrib><creatorcontrib>Gong, Biao</creatorcontrib><title>Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review</title><title>BMC pediatrics</title><addtitle>BMC PEDIATR</addtitle><addtitle>BMC Pediatr</addtitle><description>BackgroundPancreaticopleural fistula (PPF) is a very rare and critical complication of pancreatitis in children. The majority of publications relevant to PPF are case reports. No pooled analyses of PPF cases are available. Little is known about the pathogenesis and optimal therapeutic schedule. The purpose of this study was to identify the pathogenesis and optimal therapeutic schedule of PPF in children.Case presentationThe patient was a 13-year-old girl who suffered from intermittent chest tightness and dyspnea for more than 3months; she was found to have chronic pancreatitis complicated by PPF. The genetic screening revealed SPINK1 mutation. She was treated with endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic retrograde pancreatic drainage (ERPD); her symptoms improved dramatically after the procedures.ConclusionsPPF is a rare pancreatic complication in children and causes significant pulmonary symptoms that can be misdiagnosed frequently. PPF in children is mainly associated with chronic pancreatitis (CP); therefore, we highlight the importance of genetic testing. Endoscopic treatment is recommended when conservative treatment is ineffective.</description><subject>Abdomen</subject><subject>Adolescent</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Child</subject><subject>Cholangiopancreatography, Endoscopic Retrograde</subject><subject>Chronic pancreatitis</subject><subject>Cysts</subject><subject>Dyspnea</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Fistula</subject><subject>Fistulas</subject><subject>Genetic aspects</subject><subject>Genetic testing</subject><subject>Health aspects</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical imaging</subject><subject>Mutation</subject><subject>Pain</subject><subject>Pancreas</subject><subject>Pancreatic Fistula - diagnosis</subject><subject>Pancreatic Fistula - etiology</subject><subject>Pancreaticopleural fistula</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Chronic - complications</subject><subject>Pancreatitis, Chronic - diagnosis</subject><subject>Pancreatitis, Chronic - therapy</subject><subject>Pathogenesis</subject><subject>Pediatrics</subject><subject>Pleural Diseases - diagnosis</subject><subject>Pleural Diseases - etiology</subject><subject>Pleural effusion</subject><subject>Science & Technology</subject><subject>Surgery</subject><subject>Teenage girls</subject><subject>Trypsin Inhibitor, Kazal Pancreatic</subject><issn>1471-2431</issn><issn>1471-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-AS9kQBBBtuZrMpleCGXxo1DQC70OZzJndrPMJmuS6dZ_b6bbrrvihQxhkpPnfU9ycoriJSXnlCr5PlKmVD0jjORBazG7fVScUlHTGROcPj6YnxTPYlwRQmsl5NPihDPRcNY0pwV-A2cCQrLGbwYcAwxlb2MaByitK83SDl1AV25tWuZV8M6acvOgSTZelFAaiFgG3PiQSnBdOdiEAdIYpuiNxe3z4kkPQ8QX9_-z4senj9_nX2bXXz9fzS-vZ6ZqRJpVDVdSIW9YVXHGoFMtb5mSFTDOOoZ5GyUTDEULyEGIlnPoWdfVEtqmJ_ysuNr5dh5WehPsGsIv7cHqu4APCw0hX3VATUC0qhUG6goEEVVb5dSkVp0Bg6SdvD7svDZju8bOoEu5OEemxzvOLvXC3-iaScUrlQ3e3hsE_3PEmPTaRoPDAA79GDUTpJG8qeWU6_Vf6MqPweVSZSq_oqxYQ_9QC8gXsK73Oa-ZTPWlZDVXdSMn6vwfVP46XOdHdtjbHD8SvDkQLBGGtIx-GJP1Lh6DbAea4GMM2O-LQYmeOlLvOlLnjtR3Halvs-jVYRn3kocWzIDaAVtsfR-NRWdwjxFCKkEIFzTPiJrbBNO55n50KUvf_b-U_wbY8Pv-</recordid><startdate>20200603</startdate><enddate>20200603</enddate><creator>Zhang, Jia-yu</creator><creator>Deng, Zhao-hui</creator><creator>Gong, Biao</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200603</creationdate><title>Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review</title><author>Zhang, Jia-yu ; Deng, Zhao-hui ; Gong, Biao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-593868e39255322ad8b3b2865a232d2e938e6242e4bae3a44b33af2dd76ab9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Adolescent</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Child</topic><topic>Cholangiopancreatography, Endoscopic Retrograde</topic><topic>Chronic pancreatitis</topic><topic>Cysts</topic><topic>Dyspnea</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Fistula</topic><topic>Fistulas</topic><topic>Genetic aspects</topic><topic>Genetic testing</topic><topic>Health aspects</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical imaging</topic><topic>Mutation</topic><topic>Pain</topic><topic>Pancreas</topic><topic>Pancreatic Fistula - diagnosis</topic><topic>Pancreatic Fistula - etiology</topic><topic>Pancreaticopleural fistula</topic><topic>Pancreatitis</topic><topic>Pancreatitis, Chronic - complications</topic><topic>Pancreatitis, Chronic - diagnosis</topic><topic>Pancreatitis, Chronic - therapy</topic><topic>Pathogenesis</topic><topic>Pediatrics</topic><topic>Pleural Diseases - diagnosis</topic><topic>Pleural Diseases - etiology</topic><topic>Pleural effusion</topic><topic>Science & Technology</topic><topic>Surgery</topic><topic>Teenage girls</topic><topic>Trypsin Inhibitor, Kazal Pancreatic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jia-yu</creatorcontrib><creatorcontrib>Deng, Zhao-hui</creatorcontrib><creatorcontrib>Gong, Biao</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jia-yu</au><au>Deng, Zhao-hui</au><au>Gong, Biao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review</atitle><jtitle>BMC pediatrics</jtitle><stitle>BMC PEDIATR</stitle><addtitle>BMC Pediatr</addtitle><date>2020-06-03</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>274</spage><epage>274</epage><pages>274-274</pages><artnum>274</artnum><issn>1471-2431</issn><eissn>1471-2431</eissn><abstract>BackgroundPancreaticopleural fistula (PPF) is a very rare and critical complication of pancreatitis in children. The majority of publications relevant to PPF are case reports. No pooled analyses of PPF cases are available. Little is known about the pathogenesis and optimal therapeutic schedule. The purpose of this study was to identify the pathogenesis and optimal therapeutic schedule of PPF in children.Case presentationThe patient was a 13-year-old girl who suffered from intermittent chest tightness and dyspnea for more than 3months; she was found to have chronic pancreatitis complicated by PPF. The genetic screening revealed SPINK1 mutation. She was treated with endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic retrograde pancreatic drainage (ERPD); her symptoms improved dramatically after the procedures.ConclusionsPPF is a rare pancreatic complication in children and causes significant pulmonary symptoms that can be misdiagnosed frequently. PPF in children is mainly associated with chronic pancreatitis (CP); therefore, we highlight the importance of genetic testing. Endoscopic treatment is recommended when conservative treatment is ineffective.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>32493299</pmid><doi>10.1186/s12887-020-02174-x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Adolescent Case Report Case reports Child Cholangiopancreatography, Endoscopic Retrograde Chronic pancreatitis Cysts Dyspnea Endoscopy Female Fistula Fistulas Genetic aspects Genetic testing Health aspects Hospitalization Humans Life Sciences & Biomedicine Medical imaging Mutation Pain Pancreas Pancreatic Fistula - diagnosis Pancreatic Fistula - etiology Pancreaticopleural fistula Pancreatitis Pancreatitis, Chronic - complications Pancreatitis, Chronic - diagnosis Pancreatitis, Chronic - therapy Pathogenesis Pediatrics Pleural Diseases - diagnosis Pleural Diseases - etiology Pleural effusion Science & Technology Surgery Teenage girls Trypsin Inhibitor, Kazal Pancreatic |
| title | Pancreaticopleural fistula in children with chronic pancreatitis: a case report and literature review |
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