Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study

Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this st...

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Veröffentlicht in:	Journal of separation science 2020-06, Vol.43 (12), p.2290-2300
Hauptverfasser:	Ren, Guanghui, Chen, Huili, Zhang, Mei, Yang, Nan, Yang, Hui, Xu, Chuanru, Li, Jiaming, Ning, Chen, Song, Zhongjin, Zhou, Shiyu, Zhang, Siliang, Wang, Xiaoqian, Lu, Yang, Li, Ning, Zhang, Yongjie, Chen, Xijing, Zhao, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Administration, Oral Animals Anticancer properties Chromatography, High Pressure Liquid Dogs Elution Female Flavones - analysis Flavones - pharmacokinetics flavonoids Flavonoids - administration & dosage Flavonoids - analysis Flavonoids - pharmacokinetics Glucuronides - analysis Glucuronides - pharmacokinetics Injections, Intravenous Ions Liquid chromatography Male Mass spectrometry Molecular Structure Pharmacokinetics Pharmacology Sodium Sulfonic Acids - analysis Sulfonic Acids - pharmacokinetics Tandem Mass Spectrometry Tissue Distribution ultra high performance liquid chromatography
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