Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study
Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this st...
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| creator | Ren, Guanghui Chen, Huili Zhang, Mei Yang, Nan Yang, Hui Xu, Chuanru Li, Jiaming Ning, Chen Song, Zhongjin Zhou, Shiyu Zhang, Siliang Wang, Xiaoqian Lu, Yang Li, Ning Zhang, Yongjie Chen, Xijing Zhao, Di |
| description | Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra‐high‐performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate after single‐dose intravenous and oral administration of Oroxylin A in beagle dogs. |
| doi_str_mv | 10.1002/jssc.201901259 |
| format | Article |
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Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra‐high‐performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate after single‐dose intravenous and oral administration of Oroxylin A in beagle dogs.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201901259</identifier><identifier>PMID: 32187438</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acetonitrile ; Administration, Oral ; Animals ; Anticancer properties ; Chromatography, High Pressure Liquid ; Dogs ; Elution ; Female ; Flavones - analysis ; Flavones - pharmacokinetics ; flavonoids ; Flavonoids - administration & dosage ; Flavonoids - analysis ; Flavonoids - pharmacokinetics ; Glucuronides - analysis ; Glucuronides - pharmacokinetics ; Injections, Intravenous ; Ions ; Liquid chromatography ; Male ; Mass spectrometry ; Molecular Structure ; Pharmacokinetics ; Pharmacology ; Sodium ; Sulfonic Acids - analysis ; Sulfonic Acids - pharmacokinetics ; Tandem Mass Spectrometry ; Tissue Distribution ; ultra high performance liquid chromatography</subject><ispartof>Journal of separation science, 2020-06, Vol.43 (12), p.2290-2300</ispartof><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4058-6807bebcd317f3fdc71a23f0ec4de91e4b4c32076fa521cf98dfdfe81cdcfa193</citedby><cites>FETCH-LOGICAL-c4058-6807bebcd317f3fdc71a23f0ec4de91e4b4c32076fa521cf98dfdfe81cdcfa193</cites><orcidid>0000-0001-6078-1863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201901259$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201901259$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32187438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Guanghui</creatorcontrib><creatorcontrib>Chen, Huili</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Yang, Nan</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Xu, Chuanru</creatorcontrib><creatorcontrib>Li, Jiaming</creatorcontrib><creatorcontrib>Ning, Chen</creatorcontrib><creatorcontrib>Song, Zhongjin</creatorcontrib><creatorcontrib>Zhou, Shiyu</creatorcontrib><creatorcontrib>Zhang, Siliang</creatorcontrib><creatorcontrib>Wang, Xiaoqian</creatorcontrib><creatorcontrib>Lu, Yang</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Zhang, Yongjie</creatorcontrib><creatorcontrib>Chen, Xijing</creatorcontrib><creatorcontrib>Zhao, Di</creatorcontrib><title>Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra‐high‐performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate after single‐dose intravenous and oral administration of Oroxylin A in beagle dogs.</description><subject>Acetonitrile</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dogs</subject><subject>Elution</subject><subject>Female</subject><subject>Flavones - analysis</subject><subject>Flavones - pharmacokinetics</subject><subject>flavonoids</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - pharmacokinetics</subject><subject>Glucuronides - analysis</subject><subject>Glucuronides - pharmacokinetics</subject><subject>Injections, Intravenous</subject><subject>Ions</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Molecular Structure</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Sodium</subject><subject>Sulfonic Acids - analysis</subject><subject>Sulfonic Acids - pharmacokinetics</subject><subject>Tandem Mass Spectrometry</subject><subject>Tissue Distribution</subject><subject>ultra high performance liquid chromatography</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu2zAQRYmgQfNot1kWBLqNHQ5JS9TScJsXHKSAm7VA8eHSkUSFFNFql0_oX_S_8iVR4MTIrovBXAzO3Lu4CJ0AmQIh9GwTo5pSAgUBOiv20CFkMJsUDPiHnSbZATqKcUMI5KIgH9EBoyByzsQh-vfN9CY0rpW98y32Fvvg_wy1a_H89J3G-dPj39tx1nVSKfjWaXOKZavfM9FrlxocU239aGjweK2MXNcGa7-OuBpwiq5d47vLH8sFvlmd3azwvOtqp7bxIy9x90uGRip_71rTO4Vjn_TwCe1bWUfz-XUfo7vz7z8Xl5Pl7cXVYr6cKE5mYpIJklemUppBbpnVKgdJmSVGcW0KMLziilGSZ1bOKChbCG21NQKUVlZCwY7R161vF_xDMrEvNz6FdowsKQdOgfFMjNR0S6ngYwzGll1wjQxDCaR86aV86aXc9TI-fHm1TVVj9A5_K2IE-Bb47Woz_MeuvF6tFpkAwZ4BIkSd1A</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Ren, Guanghui</creator><creator>Chen, Huili</creator><creator>Zhang, Mei</creator><creator>Yang, Nan</creator><creator>Yang, Hui</creator><creator>Xu, Chuanru</creator><creator>Li, Jiaming</creator><creator>Ning, Chen</creator><creator>Song, Zhongjin</creator><creator>Zhou, Shiyu</creator><creator>Zhang, Siliang</creator><creator>Wang, Xiaoqian</creator><creator>Lu, Yang</creator><creator>Li, Ning</creator><creator>Zhang, Yongjie</creator><creator>Chen, Xijing</creator><creator>Zhao, Di</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-6078-1863</orcidid></search><sort><creationdate>202006</creationdate><title>Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study</title><author>Ren, Guanghui ; Chen, Huili ; Zhang, Mei ; Yang, Nan ; Yang, Hui ; Xu, Chuanru ; Li, Jiaming ; Ning, Chen ; Song, Zhongjin ; Zhou, Shiyu ; Zhang, Siliang ; Wang, Xiaoqian ; Lu, Yang ; Li, Ning ; Zhang, Yongjie ; Chen, Xijing ; Zhao, Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4058-6807bebcd317f3fdc71a23f0ec4de91e4b4c32076fa521cf98dfdfe81cdcfa193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetonitrile</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dogs</topic><topic>Elution</topic><topic>Female</topic><topic>Flavones - analysis</topic><topic>Flavones - pharmacokinetics</topic><topic>flavonoids</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - analysis</topic><topic>Flavonoids - pharmacokinetics</topic><topic>Glucuronides - analysis</topic><topic>Glucuronides - pharmacokinetics</topic><topic>Injections, Intravenous</topic><topic>Ions</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Molecular Structure</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Sodium</topic><topic>Sulfonic Acids - analysis</topic><topic>Sulfonic Acids - pharmacokinetics</topic><topic>Tandem Mass Spectrometry</topic><topic>Tissue Distribution</topic><topic>ultra high performance liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Guanghui</creatorcontrib><creatorcontrib>Chen, Huili</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Yang, Nan</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Xu, Chuanru</creatorcontrib><creatorcontrib>Li, Jiaming</creatorcontrib><creatorcontrib>Ning, Chen</creatorcontrib><creatorcontrib>Song, Zhongjin</creatorcontrib><creatorcontrib>Zhou, Shiyu</creatorcontrib><creatorcontrib>Zhang, Siliang</creatorcontrib><creatorcontrib>Wang, Xiaoqian</creatorcontrib><creatorcontrib>Lu, Yang</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Zhang, Yongjie</creatorcontrib><creatorcontrib>Chen, Xijing</creatorcontrib><creatorcontrib>Zhao, Di</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Guanghui</au><au>Chen, Huili</au><au>Zhang, Mei</au><au>Yang, Nan</au><au>Yang, Hui</au><au>Xu, Chuanru</au><au>Li, Jiaming</au><au>Ning, Chen</au><au>Song, Zhongjin</au><au>Zhou, Shiyu</au><au>Zhang, Siliang</au><au>Wang, Xiaoqian</au><au>Lu, Yang</au><au>Li, Ning</au><au>Zhang, Yongjie</au><au>Chen, Xijing</au><au>Zhao, Di</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2020-06</date><risdate>2020</risdate><volume>43</volume><issue>12</issue><spage>2290</spage><epage>2300</epage><pages>2290-2300</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra‐high‐performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate after single‐dose intravenous and oral administration of Oroxylin A in beagle dogs.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32187438</pmid><doi>10.1002/jssc.201901259</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6078-1863</orcidid></addata></record> |
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| subjects | Acetonitrile Administration, Oral Animals Anticancer properties Chromatography, High Pressure Liquid Dogs Elution Female Flavones - analysis Flavones - pharmacokinetics flavonoids Flavonoids - administration & dosage Flavonoids - analysis Flavonoids - pharmacokinetics Glucuronides - analysis Glucuronides - pharmacokinetics Injections, Intravenous Ions Liquid chromatography Male Mass spectrometry Molecular Structure Pharmacokinetics Pharmacology Sodium Sulfonic Acids - analysis Sulfonic Acids - pharmacokinetics Tandem Mass Spectrometry Tissue Distribution ultra high performance liquid chromatography |
| title | Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study |
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