Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics

Background and Objective Fluoxetine, antidepressant widely-used during pregnancy, is a selective inhibitor for P-glycoprotein (P-gp). Fexofenadine, an in vivo P-gp probe, is an antihistamine drug for seasonal allergic rhinitis and chronic urticaria treatment during pregnancy and it is available as a...

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Veröffentlicht in:	Pharmaceutical research 2020-07, Vol.37 (7), p.131, Article 131
Hauptverfasser:	Pinto, Leonardo, Moreira, Fernanda de Lima, Nardotto, Glauco Henrique Balthazar, Cavalli, Ricardo Carvalho, Moisés, Elaine Christine Dantas, Duarte, Geraldo, Lanchote, Vera Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergic rhinitis Antidepressive Agents, Second-Generation - administration & dosage Antidepressive Agents, Second-Generation - adverse effects Antihistamines ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B - metabolism Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Case-Control Studies Discrimination Drug Interactions Enantiomers Female Fetal Blood - metabolism Fetuses Fexofenadine Fluoxetine Fluoxetine - administration & dosage Fluoxetine - adverse effects Glycoproteins Histamine H1 Antagonists, Non-Sedating - administration & dosage Histamine H1 Antagonists, Non-Sedating - blood Histamine H1 Antagonists, Non-Sedating - pharmacokinetics Humans Intestinal Absorption - drug effects Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Maternal-Fetal Exchange Medical Law P-Glycoprotein Parturition Pharmacokinetics Pharmacology/Toxicology Pharmacy Placenta Placental Circulation Pregnancy Research Paper Terfenadine - administration & dosage Terfenadine - analogs & derivatives Terfenadine - blood Terfenadine - pharmacokinetics Urticaria Young Adult
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