Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic
Increasing anthropogenic activities related to industrialization and exposure to different toxicants increases the health hazards of industrial workers. Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores...
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| Veröffentlicht in: | Toxicology and industrial health 2020-03, Vol.36 (3), p.161-169 |
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| creator | Khalid, Nayab Mahjabeen, Ishrat Kayani, Mahmood Akhtar Akram, Zertashia |
| description | Increasing anthropogenic activities related to industrialization and exposure to different toxicants increases the health hazards of industrial workers. Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores the expression variation of As 3 methyltransferase (AS3MT) and superoxide dismutase (SOD2) genes in blood samples of industrial workers of different industries (brick kiln, paint, welding, pesticide, and furniture) using quantitative real-time polymerase chain reaction. A total of 250 blood samples of industrial workers were collected along with age- and gender-matched controls. Relative expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) genes was found significantly downregulated in exposed workers compared to controls. Significant low levels of AS3MT and SOD2 gene expression were observed in workers in the paint and pesticide industry compared to other industries. Similarly, reduced expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) was observed in smokers of industrial workers compared to smokers of the control group. Workers with >10 years of exposure had less AS3MT expression compared to workers with |
| doi_str_mv | 10.1177/0748233720918680 |
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Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores the expression variation of As 3 methyltransferase (AS3MT) and superoxide dismutase (SOD2) genes in blood samples of industrial workers of different industries (brick kiln, paint, welding, pesticide, and furniture) using quantitative real-time polymerase chain reaction. A total of 250 blood samples of industrial workers were collected along with age- and gender-matched controls. Relative expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) genes was found significantly downregulated in exposed workers compared to controls. Significant low levels of AS3MT and SOD2 gene expression were observed in workers in the paint and pesticide industry compared to other industries. Similarly, reduced expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) was observed in smokers of industrial workers compared to smokers of the control group. Workers with >10 years of exposure had less AS3MT expression compared to workers with <10 years of exposure. Additionally, a positive Spearman correlation was observed between AS3MT versus SOD2 (r = 0.742; p < 0.0001) in industrial workers. This study suggests that decreased AS3MT and SOD2 expression levels may lead to bioaccumulation of As in the body accompanied by increased oxidative stress ultimately inducing DNA damage.]]></description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233720918680</identifier><identifier>PMID: 32539644</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Anthropogenic factors ; Antioxidants ; Arsenic ; Arsenic - adverse effects ; Arsenic - blood ; Bioaccumulation ; Blood ; Case-Control Studies ; Damage ; Deoxyribonucleic acid ; DNA ; DNA damage ; Exposure ; Gene expression ; Genes ; Genotype ; Health hazards ; Humans ; Industry ; Kilns ; Levels ; Male ; Methyltransferase ; Methyltransferases - genetics ; Middle Aged ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Oxidative stress ; Oxidative Stress - drug effects ; Pakistan ; Pesticides ; Phenotypes ; Polymerase chain reaction ; Reactive oxygen species ; Smoking ; Superoxide dismutase ; Superoxide Dismutase - genetics ; Toxic hazards ; Toxicants ; Young Adult</subject><ispartof>Toxicology and industrial health, 2020-03, Vol.36 (3), p.161-169</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-cbfd3193aec2ecd2725d7df3b7226f43c123701c8b1e9d051ab229241f6a94763</citedby><cites>FETCH-LOGICAL-c365t-cbfd3193aec2ecd2725d7df3b7226f43c123701c8b1e9d051ab229241f6a94763</cites><orcidid>0000-0003-3364-5510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233720918680$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233720918680$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32539644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalid, Nayab</creatorcontrib><creatorcontrib>Mahjabeen, Ishrat</creatorcontrib><creatorcontrib>Kayani, Mahmood Akhtar</creatorcontrib><creatorcontrib>Akram, Zertashia</creatorcontrib><title>Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description><![CDATA[Increasing anthropogenic activities related to industrialization and exposure to different toxicants increases the health hazards of industrial workers. Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores the expression variation of As 3 methyltransferase (AS3MT) and superoxide dismutase (SOD2) genes in blood samples of industrial workers of different industries (brick kiln, paint, welding, pesticide, and furniture) using quantitative real-time polymerase chain reaction. A total of 250 blood samples of industrial workers were collected along with age- and gender-matched controls. Relative expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) genes was found significantly downregulated in exposed workers compared to controls. Significant low levels of AS3MT and SOD2 gene expression were observed in workers in the paint and pesticide industry compared to other industries. Similarly, reduced expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) was observed in smokers of industrial workers compared to smokers of the control group. Workers with >10 years of exposure had less AS3MT expression compared to workers with <10 years of exposure. Additionally, a positive Spearman correlation was observed between AS3MT versus SOD2 (r = 0.742; p < 0.0001) in industrial workers. This study suggests that decreased AS3MT and SOD2 expression levels may lead to bioaccumulation of As in the body accompanied by increased oxidative stress ultimately inducing DNA damage.]]></description><subject>Adult</subject><subject>Anthropogenic factors</subject><subject>Antioxidants</subject><subject>Arsenic</subject><subject>Arsenic - adverse effects</subject><subject>Arsenic - blood</subject><subject>Bioaccumulation</subject><subject>Blood</subject><subject>Case-Control Studies</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Exposure</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genotype</subject><subject>Health hazards</subject><subject>Humans</subject><subject>Industry</subject><subject>Kilns</subject><subject>Levels</subject><subject>Male</subject><subject>Methyltransferase</subject><subject>Methyltransferases - genetics</subject><subject>Middle Aged</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pakistan</subject><subject>Pesticides</subject><subject>Phenotypes</subject><subject>Polymerase chain reaction</subject><subject>Reactive oxygen species</subject><subject>Smoking</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - genetics</subject><subject>Toxic hazards</subject><subject>Toxicants</subject><subject>Young Adult</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAYhYMobk7vvZKA19V8tElzOeYnTHaxeV3SJB2dXTOTFrc_4O82tZuCICS8F-d5z3k5AFxidIMx57eIxymhlBMkcMpSdASGOOY8QlTQYzDs5KjTB-DM-xVCiLGEnIIBJQkVLI6H4HPsvVWlbEpbQ1tA6bypSxU5U8nGaDie05cFXJraQFnr8AO4LXWYcD67I71ithtnvO8syu7p1jeulBX8sO7NOA-tUu3mO0NW1a7jrQ_mjT3knYOTQlbeXOznCLw-3C8mT9F09vg8GU8jRVnSRCovNMWCSqOIUZpwkmiuC5pzQlgRU4UJ5QirNMdGaJRgmRMiSIwLJkXMGR2B69534-x7a3yTrWzrwlU-CxQVKOaIBwr1lHLWe2eKbOPKtXS7DKOsKz77W3xYudobt_na6J-FQ9MBiHrAy6X5Tf3X8AscVIwf</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Khalid, Nayab</creator><creator>Mahjabeen, Ishrat</creator><creator>Kayani, Mahmood Akhtar</creator><creator>Akram, Zertashia</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><orcidid>https://orcid.org/0000-0003-3364-5510</orcidid></search><sort><creationdate>202003</creationdate><title>Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic</title><author>Khalid, Nayab ; 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Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores the expression variation of As 3 methyltransferase (AS3MT) and superoxide dismutase (SOD2) genes in blood samples of industrial workers of different industries (brick kiln, paint, welding, pesticide, and furniture) using quantitative real-time polymerase chain reaction. A total of 250 blood samples of industrial workers were collected along with age- and gender-matched controls. Relative expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) genes was found significantly downregulated in exposed workers compared to controls. Significant low levels of AS3MT and SOD2 gene expression were observed in workers in the paint and pesticide industry compared to other industries. Similarly, reduced expression of AS3MT (p < 0.05) and SOD2 (p < 0.01) was observed in smokers of industrial workers compared to smokers of the control group. Workers with >10 years of exposure had less AS3MT expression compared to workers with <10 years of exposure. Additionally, a positive Spearman correlation was observed between AS3MT versus SOD2 (r = 0.742; p < 0.0001) in industrial workers. This study suggests that decreased AS3MT and SOD2 expression levels may lead to bioaccumulation of As in the body accompanied by increased oxidative stress ultimately inducing DNA damage.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32539644</pmid><doi>10.1177/0748233720918680</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3364-5510</orcidid></addata></record> |
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| subjects | Adult Anthropogenic factors Antioxidants Arsenic Arsenic - adverse effects Arsenic - blood Bioaccumulation Blood Case-Control Studies Damage Deoxyribonucleic acid DNA DNA damage Exposure Gene expression Genes Genotype Health hazards Humans Industry Kilns Levels Male Methyltransferase Methyltransferases - genetics Middle Aged Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - analysis Oxidative stress Oxidative Stress - drug effects Pakistan Pesticides Phenotypes Polymerase chain reaction Reactive oxygen species Smoking Superoxide dismutase Superoxide Dismutase - genetics Toxic hazards Toxicants Young Adult |
| title | Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic |
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