Melatonin Enhances the Chemotherapeutic Effect of Cytarabin in HL-60 Cells

The combined effect of melatonin and cytarabin at low concentration on the cells of acute promyelocytic leukemia HL-60 was studied. It has been shown that the combined effect of these substances led to a decrease in the number of cells by 70% and the mitotic activity index by 75%. It was found that...

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Veröffentlicht in:	Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2020-04, Vol.14 (2), p.140-145
Hauptverfasser:	Lomovsky, A. I., Baburina, Yu. L., Kobyakova, M. I., Fadeev, R. S., Akatov, V. S., Krestinina, O. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyeloid leukemia Anticancer properties Antitumor activity Apoptosis Bcl-2 protein Biomedical and Life Sciences Cell Biology Ion channels Leukemia Life Sciences Melatonin Mitochondria Promyeloid leukemia Proteins Synergistic effect
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