Ethinylestradiol and its effects on the macrophages in the prostate of adult and senile gerbils
Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological ef...
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| Veröffentlicht in: | Cell biology international 2020-07, Vol.44 (7), p.1467-1480 |
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| creator | Castro, Nayara F. C. Falleiros‐Júnior, Luiz R. Zucão, Mariele I. Perez, Ana P. S. Taboga, Sebastião R. Santos, Fernanda C. A. Vilamaior, Patrícia S. L. |
| description | Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging. |
| doi_str_mv | 10.1002/cbin.11342 |
| format | Article |
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C. ; Falleiros‐Júnior, Luiz R. ; Zucão, Mariele I. ; Perez, Ana P. S. ; Taboga, Sebastião R. ; Santos, Fernanda C. A. ; Vilamaior, Patrícia S. L.</creator><creatorcontrib>Castro, Nayara F. C. ; Falleiros‐Júnior, Luiz R. ; Zucão, Mariele I. ; Perez, Ana P. S. ; Taboga, Sebastião R. ; Santos, Fernanda C. A. ; Vilamaior, Patrícia S. L.</creatorcontrib><description>Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging.</description><identifier>ISSN: 1065-6995</identifier><identifier>EISSN: 1095-8355</identifier><identifier>DOI: 10.1002/cbin.11342</identifier><identifier>PMID: 32181948</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aging ; Animals ; Developmental disabilities ; Epithelium ; Epithelium - metabolism ; Estrogen Receptor alpha - metabolism ; Estrogens - metabolism ; Ethinyl Estradiol - metabolism ; Ethinyl Estradiol - pharmacology ; Ethinylestradiol ; Female ; Gerbillinae - metabolism ; gland ; Glands ; Lactation ; macrophage ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Male ; Mineral oils ; neonatal ; Neonates ; Pregnancy ; Prenatal experience ; Prenatal Exposure Delayed Effects - metabolism ; Prostate ; Prostate - drug effects ; Receptors, Androgen - drug effects ; Receptors, Androgen - metabolism ; Stroma ; Testosterone - metabolism ; Xenoestrogens</subject><ispartof>Cell biology international, 2020-07, Vol.44 (7), p.1467-1480</ispartof><rights>2020 International Federation for Cell Biology</rights><rights>2020 International Federation for Cell Biology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-2ee4e4b713fd575e49ef812e184c715cb8a02d0bab85f797bfd87f2c2264f8853</citedby><cites>FETCH-LOGICAL-c3572-2ee4e4b713fd575e49ef812e184c715cb8a02d0bab85f797bfd87f2c2264f8853</cites><orcidid>0000-0001-9559-5497 ; 0000-0002-0970-4288 ; 0000-0002-4476-6046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbin.11342$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbin.11342$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32181948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro, Nayara F. C.</creatorcontrib><creatorcontrib>Falleiros‐Júnior, Luiz R.</creatorcontrib><creatorcontrib>Zucão, Mariele I.</creatorcontrib><creatorcontrib>Perez, Ana P. S.</creatorcontrib><creatorcontrib>Taboga, Sebastião R.</creatorcontrib><creatorcontrib>Santos, Fernanda C. A.</creatorcontrib><creatorcontrib>Vilamaior, Patrícia S. L.</creatorcontrib><title>Ethinylestradiol and its effects on the macrophages in the prostate of adult and senile gerbils</title><title>Cell biology international</title><addtitle>Cell Biol Int</addtitle><description>Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging.</description><subject>Aging</subject><subject>Animals</subject><subject>Developmental disabilities</subject><subject>Epithelium</subject><subject>Epithelium - metabolism</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogens - metabolism</subject><subject>Ethinyl Estradiol - metabolism</subject><subject>Ethinyl Estradiol - pharmacology</subject><subject>Ethinylestradiol</subject><subject>Female</subject><subject>Gerbillinae - metabolism</subject><subject>gland</subject><subject>Glands</subject><subject>Lactation</subject><subject>macrophage</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Mineral oils</subject><subject>neonatal</subject><subject>Neonates</subject><subject>Pregnancy</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>Prostate</subject><subject>Prostate - drug effects</subject><subject>Receptors, Androgen - drug effects</subject><subject>Receptors, Androgen - metabolism</subject><subject>Stroma</subject><subject>Testosterone - metabolism</subject><subject>Xenoestrogens</subject><issn>1065-6995</issn><issn>1095-8355</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwzAMxSMEYmNw4QOgSNyQOuI0adMjTOOPNMEFzlHSOlunrh1NK7RvT7YOjpxsWT8_-z1CroFNgTF-n9uyngLEgp-QMbBMRiqW8nTfJzJKskyOyIX3a8YAhErOySjmoCATakz0vFuV9a5C37WmKJuKmrqgZecpOod5qE1NuxXSjcnbZrsyS_S0HEbbtvGd6ZA2jpqir7rDrse6rJAusbVl5S_JmTOVx6tjnZDPp_nH7CVavD-_zh4WUR7LlEccUaCwKcSukKlEkaFTwBGUyFOQuVWG8YJZY5V0aZZaV6jU8ZzzRDilZDwht4NueOqrD270uunbOpzUXADPJAOZBOpuoIIX71t0etuWG9PuNDC9z1Lvs9SHLAN8c5Ts7QaLP_Q3vADAAHwHw7t_pPTs8fVtEP0BsLl-9Q</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Castro, Nayara F. 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A.</au><au>Vilamaior, Patrícia S. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethinylestradiol and its effects on the macrophages in the prostate of adult and senile gerbils</atitle><jtitle>Cell biology international</jtitle><addtitle>Cell Biol Int</addtitle><date>2020-07</date><risdate>2020</risdate><volume>44</volume><issue>7</issue><spage>1467</spage><epage>1480</epage><pages>1467-1480</pages><issn>1065-6995</issn><eissn>1095-8355</eissn><abstract>Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32181948</pmid><doi>10.1002/cbin.11342</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9559-5497</orcidid><orcidid>https://orcid.org/0000-0002-0970-4288</orcidid><orcidid>https://orcid.org/0000-0002-4476-6046</orcidid></addata></record> |
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| subjects | Aging Animals Developmental disabilities Epithelium Epithelium - metabolism Estrogen Receptor alpha - metabolism Estrogens - metabolism Ethinyl Estradiol - metabolism Ethinyl Estradiol - pharmacology Ethinylestradiol Female Gerbillinae - metabolism gland Glands Lactation macrophage Macrophages Macrophages - drug effects Macrophages - metabolism Male Mineral oils neonatal Neonates Pregnancy Prenatal experience Prenatal Exposure Delayed Effects - metabolism Prostate Prostate - drug effects Receptors, Androgen - drug effects Receptors, Androgen - metabolism Stroma Testosterone - metabolism Xenoestrogens |
| title | Ethinylestradiol and its effects on the macrophages in the prostate of adult and senile gerbils |
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