The natural flavonoid galangin ameliorates dextran sulphate sodium–induced ulcerative colitis in mice: Effect on Toll‐like receptor 4, inflammation and oxidative stress

This study was carried out to investigate the potential therapeutic effect of galangin, a promising active principle of honeybee propolis, in dextran sulphate sodium (DSS)–induced colitis in mice. We explored the possible underlying mechanisms for galangin action and the therapeutic benefit of addin...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2020-07, Vol.127 (1), p.10-20
Hauptverfasser:	Gerges, Samar H., Tolba, Mai F., Elsherbiny, Doaa A., El‐Demerdash, Ebtehal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - drug effects Colon - metabolism Colon - pathology Cytokines Cytokines - metabolism Dextran Dextran Sulfate dextran sulphate sodium Drinking water Flavonoids Flavonoids - pharmacology galangin Inflammatory bowel disease Inflammatory bowel diseases Mice NF-kappa B - metabolism nuclear factor kappa B Oxidative stress Oxidative Stress - drug effects Propolis Receptors Sodium Sulfasalazine - pharmacology Sulfates sulphasalazine Toll-Like Receptor 4 - metabolism Toll-like receptors toll‐like receptor 4 Ulcerative colitis
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