Metronidazole‐loaded glass ionomer dental cements
The incorporation of antibiotics in glass ionomer cements (GICs) for the treatment of periodontal diseases has been considered as an effective therapeutic strategy. In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic...
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| Veröffentlicht in: | International journal of applied ceramic technology 2020-07, Vol.17 (4), p.1985-1997 |
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| container_end_page | 1997 |
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| container_issue | 4 |
| container_start_page | 1985 |
| container_title | International journal of applied ceramic technology |
| container_volume | 17 |
| creator | Salehi, Ghazaleh Behnamghader, Aliasghar Pazouki, Mohamad Mozafari, Masoud |
| description | The incorporation of antibiotics in glass ionomer cements (GICs) for the treatment of periodontal diseases has been considered as an effective therapeutic strategy. In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic were made by adding 6.0 w% silanized E‐glass fibers and 3.0 w% metronidazole to the GIC powder. The GIC reinforced with 6.0 w% silanized fibers showed maximum values of 57 MPa, 2.1 GPa, and 1.3 MPa‧m0.5 for the flexural strength, flexural modulus, and fracture toughness, respectively. The release of metronidazole showed a two‐step release in which about 65% of total amount was released in the first 24 hours. Antibacterial test exhibited no bacteria number (CFU/mL) in the presence of GIC containing metronidazole. In addition, gene expression of Streptococcus mutans was performed by real‐time PCR method. Based on PCR results, metronidazole significantly reduced the gtfB and gtfC genes expression, related to adherence and biofilm formation, up to 98% after 7 days in comparison to the control one (P |
| doi_str_mv | 10.1111/ijac.13480 |
| format | Article |
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In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic were made by adding 6.0 w% silanized E‐glass fibers and 3.0 w% metronidazole to the GIC powder. The GIC reinforced with 6.0 w% silanized fibers showed maximum values of 57 MPa, 2.1 GPa, and 1.3 MPa‧m0.5 for the flexural strength, flexural modulus, and fracture toughness, respectively. The release of metronidazole showed a two‐step release in which about 65% of total amount was released in the first 24 hours. Antibacterial test exhibited no bacteria number (CFU/mL) in the presence of GIC containing metronidazole. In addition, gene expression of Streptococcus mutans was performed by real‐time PCR method. Based on PCR results, metronidazole significantly reduced the gtfB and gtfC genes expression, related to adherence and biofilm formation, up to 98% after 7 days in comparison to the control one (P < .001). According to the obtained results, GICs reinforced with silanized fibers containing metronidazole are effective in inhibiting bacteria associated with caries and also acceptable mechanical properties for the development of the next generation of restoration dental materials.</description><identifier>ISSN: 1546-542X</identifier><identifier>EISSN: 1744-7402</identifier><identifier>DOI: 10.1111/ijac.13480</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Antibiotics ; Bacteria ; bioactivity ; Cement reinforcements ; Dental cement ; Dental materials ; dental replacement ; fibers ; Flexural strength ; Fracture toughness ; Gene expression ; Glass fibers ; Glass ionomer cements ; glass‐ceramics ; Mechanical properties ; Modulus of rupture in bending ; Reinforced cements ; Restoration</subject><ispartof>International journal of applied ceramic technology, 2020-07, Vol.17 (4), p.1985-1997</ispartof><rights>2020 The American Ceramic Society</rights><rights>Copyright © 2020 American Ceramic Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3010-c29988c86bf9e21833df9acc7f6096efd2b2c2b19d2a409d0963990a632d5c883</citedby><cites>FETCH-LOGICAL-c3010-c29988c86bf9e21833df9acc7f6096efd2b2c2b19d2a409d0963990a632d5c883</cites><orcidid>0000-0002-0232-352X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijac.13480$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijac.13480$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Salehi, Ghazaleh</creatorcontrib><creatorcontrib>Behnamghader, Aliasghar</creatorcontrib><creatorcontrib>Pazouki, Mohamad</creatorcontrib><creatorcontrib>Mozafari, Masoud</creatorcontrib><title>Metronidazole‐loaded glass ionomer dental cements</title><title>International journal of applied ceramic technology</title><description>The incorporation of antibiotics in glass ionomer cements (GICs) for the treatment of periodontal diseases has been considered as an effective therapeutic strategy. In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic were made by adding 6.0 w% silanized E‐glass fibers and 3.0 w% metronidazole to the GIC powder. The GIC reinforced with 6.0 w% silanized fibers showed maximum values of 57 MPa, 2.1 GPa, and 1.3 MPa‧m0.5 for the flexural strength, flexural modulus, and fracture toughness, respectively. The release of metronidazole showed a two‐step release in which about 65% of total amount was released in the first 24 hours. Antibacterial test exhibited no bacteria number (CFU/mL) in the presence of GIC containing metronidazole. In addition, gene expression of Streptococcus mutans was performed by real‐time PCR method. Based on PCR results, metronidazole significantly reduced the gtfB and gtfC genes expression, related to adherence and biofilm formation, up to 98% after 7 days in comparison to the control one (P < .001). According to the obtained results, GICs reinforced with silanized fibers containing metronidazole are effective in inhibiting bacteria associated with caries and also acceptable mechanical properties for the development of the next generation of restoration dental materials.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>bioactivity</subject><subject>Cement reinforcements</subject><subject>Dental cement</subject><subject>Dental materials</subject><subject>dental replacement</subject><subject>fibers</subject><subject>Flexural strength</subject><subject>Fracture toughness</subject><subject>Gene expression</subject><subject>Glass fibers</subject><subject>Glass ionomer cements</subject><subject>glass‐ceramics</subject><subject>Mechanical properties</subject><subject>Modulus of rupture in bending</subject><subject>Reinforced cements</subject><subject>Restoration</subject><issn>1546-542X</issn><issn>1744-7402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoOI5ufIKCO6Fjbk2T5VC8jIy4UXAX0lykpW3GpIOMKx_BZ_RJzFjXns35OXznHPgAOEdwgVJdNa3SC0QohwdghkpK85JCfJhyQVleUPxyDE5ibCEklBA2A-TBjsEPjVEfvrPfn1-dV8aa7LVTMWaNH3xvQ2bsMKou07ZPIZ6CI6e6aM_--hw831w_VXf5-vF2VS3XuSYQwVxjITjXnNVOWIw4IcYJpXXpGBTMOoNrrHGNhMGKQmHSkAgBFSPYFJpzMgcX091N8G9bG0fZ-m0Y0kuJKcKwIAKJRF1OlA4-xmCd3ISmV2EnEZR7KXIvRf5KSTCa4Pems7t_SLm6X1bTzg-BYmQg</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Salehi, Ghazaleh</creator><creator>Behnamghader, Aliasghar</creator><creator>Pazouki, Mohamad</creator><creator>Mozafari, Masoud</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QQ</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-0232-352X</orcidid></search><sort><creationdate>202007</creationdate><title>Metronidazole‐loaded glass ionomer dental cements</title><author>Salehi, Ghazaleh ; Behnamghader, Aliasghar ; Pazouki, Mohamad ; Mozafari, Masoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3010-c29988c86bf9e21833df9acc7f6096efd2b2c2b19d2a409d0963990a632d5c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotics</topic><topic>Bacteria</topic><topic>bioactivity</topic><topic>Cement reinforcements</topic><topic>Dental cement</topic><topic>Dental materials</topic><topic>dental replacement</topic><topic>fibers</topic><topic>Flexural strength</topic><topic>Fracture toughness</topic><topic>Gene expression</topic><topic>Glass fibers</topic><topic>Glass ionomer cements</topic><topic>glass‐ceramics</topic><topic>Mechanical properties</topic><topic>Modulus of rupture in bending</topic><topic>Reinforced cements</topic><topic>Restoration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salehi, Ghazaleh</creatorcontrib><creatorcontrib>Behnamghader, Aliasghar</creatorcontrib><creatorcontrib>Pazouki, Mohamad</creatorcontrib><creatorcontrib>Mozafari, Masoud</creatorcontrib><collection>CrossRef</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>International journal of applied ceramic technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salehi, Ghazaleh</au><au>Behnamghader, Aliasghar</au><au>Pazouki, Mohamad</au><au>Mozafari, Masoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metronidazole‐loaded glass ionomer dental cements</atitle><jtitle>International journal of applied ceramic technology</jtitle><date>2020-07</date><risdate>2020</risdate><volume>17</volume><issue>4</issue><spage>1985</spage><epage>1997</epage><pages>1985-1997</pages><issn>1546-542X</issn><eissn>1744-7402</eissn><abstract>The incorporation of antibiotics in glass ionomer cements (GICs) for the treatment of periodontal diseases has been considered as an effective therapeutic strategy. In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic were made by adding 6.0 w% silanized E‐glass fibers and 3.0 w% metronidazole to the GIC powder. The GIC reinforced with 6.0 w% silanized fibers showed maximum values of 57 MPa, 2.1 GPa, and 1.3 MPa‧m0.5 for the flexural strength, flexural modulus, and fracture toughness, respectively. The release of metronidazole showed a two‐step release in which about 65% of total amount was released in the first 24 hours. Antibacterial test exhibited no bacteria number (CFU/mL) in the presence of GIC containing metronidazole. In addition, gene expression of Streptococcus mutans was performed by real‐time PCR method. Based on PCR results, metronidazole significantly reduced the gtfB and gtfC genes expression, related to adherence and biofilm formation, up to 98% after 7 days in comparison to the control one (P < .001). According to the obtained results, GICs reinforced with silanized fibers containing metronidazole are effective in inhibiting bacteria associated with caries and also acceptable mechanical properties for the development of the next generation of restoration dental materials.</abstract><cop>Malden</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/ijac.13480</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0232-352X</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Antibiotics Bacteria bioactivity Cement reinforcements Dental cement Dental materials dental replacement fibers Flexural strength Fracture toughness Gene expression Glass fibers Glass ionomer cements glass‐ceramics Mechanical properties Modulus of rupture in bending Reinforced cements Restoration |
| title | Metronidazole‐loaded glass ionomer dental cements |
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