Drug Elimination in Two-Compartment Pharmacokinetic Models with Nonstandard Finite Difference Approach
We use the nonstandard finite difference (NSFD) method to solve the two-compartments pharmacokinetic models of drug elimination. Pharmacokinetic models are commonly used to predict drug concentrations in the body. These models are modeled by nonlinear ordinary differential equations. We apply the NS...
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| Veröffentlicht in: | IAENG international journal of applied mathematics 2020-06, Vol.50 (2), p.1-7 |
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| creator | Sa'adah, A M Niswatus Widodo Indarsih |
| description | We use the nonstandard finite difference (NSFD) method to solve the two-compartments pharmacokinetic models of drug elimination. Pharmacokinetic models are commonly used to predict drug concentrations in the body. These models are modeled by nonlinear ordinary differential equations. We apply the NSFD rules, based on Mickens' idea of transferring nonlinear models into discrete schemes. The method used was compared with other established methods to verify its efficiency and accuracy. Two-compartment pharmacokinetic models are considered for different routes of administration: I.V. bolus injection and I.V. bolus infusion. |
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| identifier | ISSN: 1992-9978 |
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| issn | 1992-9978 1992-9986 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Drug delivery systems Finite difference method Mathematical analysis Model accuracy Nonlinear differential equations Nonlinear equations Ordinary differential equations Pharmacokinetics Pharmacology |
| title | Drug Elimination in Two-Compartment Pharmacokinetic Models with Nonstandard Finite Difference Approach |
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