Activation of Farnesoid X Receptor by Schaftoside Ameliorates Acetaminophen-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammation

Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic mitochondrial oxidative stress and inflammation. However, the molecular mechanisms involved are still unclear. Farnesoid X receptor (FXR) serves as a therapeutic target for the treatment of liver disorders, whose activatio...

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Veröffentlicht in:	Antioxidants & redox signaling 2020-07, Vol.33 (2), p.87-116
Hauptverfasser:	Liu, Meijing, Zhang, Guohui, Song, Meng, Wang, Jueyu, Shen, Chuangpeng, Chen, Zhao, Huang, Xingan, Gao, Yong, Zhu, Chenchen, Lin, Chaozhan, Mi, Suiqing, Liu, Changhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Activation Analgesics Bile Cysteine Efflux Eicosanoids Enzymes Flavonoids Glutamate-cysteine ligase Glutathione Hepatocytes Hepatotoxicity Inflammation Liver Liver diseases Metabolic pathways Metabolism Mitochondria Molecular modelling Overdose Oxidative stress Protein transport Protein turnover Receptors Signaling Therapeutic applications
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