Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death—Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9

Parkinson’s disease (PD) results from the degeneration of the nervous tissue brought about by ecological and hereditary components which affects nerve cells in the brain. It is the world’s second most normal neurodegenerative issue, which can essentially weaken the personal satisfaction, make relian...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2020-06, Vol.191 (2), p.555-566
Hauptverfasser:	J., Bindhu, Das, Arunava, Sakthivel, K. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Aged Aged, 80 and over Anthraquinone Anthraquinones Apoptosis Apoptosis - drug effects Basal ganglia Biochemistry Biocompatibility Biosynthesis Biotechnology Brain diseases Caspase 3 Cell death Cell Death - drug effects Cell Survival - drug effects Central nervous system diseases Chemistry Chemistry and Materials Science Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Cytochrome c Cytochromes Cytotoxicity Degeneration Dopamine Dopamine D2 receptors Editing Fungi Gene Knockout Techniques Genes Genome editing Genomes Health services Humans Immunoblotting India Kinases Membrane potential Membrane Potential, Mitochondrial - drug effects Metabolites Mitochondria Movement disorders Mutation Nervous tissues Neuroblastoma Neuroblastoma - metabolism Neuroblasts Neurodegeneration Neurodegenerative diseases Neurotoxicity Neurotoxins Oxidative Stress Oxidopamine - adverse effects PARK7 protein Parkinson Disease - metabolism Parkinson's disease Pleurotus - metabolism Pleurotus ostreatus Protective Agents - pharmacology Protein Deglycase DJ-1 - metabolism Protein Kinases - metabolism PTEN protein Reactive Oxygen Species - metabolism Signs and symptoms Toxicity Toxins
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