Drug Delivery of Amphotericin B through Core-Shell Composite Based on PLGA/Ag/Fe3O4: In Vitro Test
This research aimed at developing and designing a slow and targeted delivery of Amphotericin B (AmB) antibiotic by placing three types of shells containing different ratios of biodegradable and biocompatible polymers poly (D, L-lactide)-co-(glycolide) (PLGA), polyethylene glycol (PEG), and polyvinyl...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2020-06, Vol.191 (2), p.496-510 |
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| description | This research aimed at developing and designing a slow and targeted delivery of Amphotericin B (AmB) antibiotic by placing three types of shells containing different ratios of biodegradable and biocompatible polymers poly (D, L-lactide)-co-(glycolide) (PLGA), polyethylene glycol (PEG), and polyvinyl pyrrolidone (PVP) on core-shell structures including silver nanoparticles that were activated with magnetic nanoparticles (MNPs). Emulsion solvent evaporation technique was employed to synthesize three types of shells: (i) (PVP-PEG) (100:20, w/w), (ii) (PLGA-PEG) (100:20, w/w), and (iii) (PLGA-PEG) (50:10, w/w) introduced as D1, D2, and D3 respectively. The in vitro release of AmB was examined in aqueous medium phosphate buffer saline (PBS) in pH~ 7.2. Several spectroscopy methods characterized the structure and properties of the nanoparticles. In vitro antifungal activity of pure AmB and D1, D2, and D3 was studied against
Candida albicans
(
C. albicans
). The results explained that frequency of drug released from D2 at the first 10 h was (18%) that was compared with D1 (30%) and D3 (24%) at the same time. D2 had more efficient and longer targeted controlled release. The findings showed that D2 can be used as an effective carrier for in vitro targeted controlled release and D2 and D3 had powerful activity against
C. albicans
. |
| doi_str_mv | 10.1007/s12010-019-03181-0 |
| format | Article |
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Candida albicans
(
C. albicans
). The results explained that frequency of drug released from D2 at the first 10 h was (18%) that was compared with D1 (30%) and D3 (24%) at the same time. D2 had more efficient and longer targeted controlled release. The findings showed that D2 can be used as an effective carrier for in vitro targeted controlled release and D2 and D3 had powerful activity against
C. albicans
.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/s12010-019-03181-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amphotericin B ; Antibiotics ; Antifungal activity ; Antifungal agents ; Aqueous solutions ; Biochemistry ; Biocompatibility ; Biodegradability ; Biodegradation ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Controlled release ; Core-shell structure ; Drug delivery ; Drug delivery systems ; Evaporation ; Fungicides ; In vitro methods and tests ; Iron oxides ; Nanoparticles ; Polyethylene glycol ; Polylactide-co-glycolide ; Polymers ; Polyvinylpyrrolidone ; Shells ; Silver ; Spectroscopy</subject><ispartof>Applied biochemistry and biotechnology, 2020-06, Vol.191 (2), p.496-510</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1d18c932f9d3972769ceb6c59e78f7a4c77b2a95521a908760051bb60c3c9fd93</citedby><cites>FETCH-LOGICAL-c389t-1d18c932f9d3972769ceb6c59e78f7a4c77b2a95521a908760051bb60c3c9fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12010-019-03181-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12010-019-03181-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Sadat Akhavi, Shiva</creatorcontrib><creatorcontrib>Moradi Dehaghi, Shahram</creatorcontrib><title>Drug Delivery of Amphotericin B through Core-Shell Composite Based on PLGA/Ag/Fe3O4: In Vitro Test</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><description>This research aimed at developing and designing a slow and targeted delivery of Amphotericin B (AmB) antibiotic by placing three types of shells containing different ratios of biodegradable and biocompatible polymers poly (D, L-lactide)-co-(glycolide) (PLGA), polyethylene glycol (PEG), and polyvinyl pyrrolidone (PVP) on core-shell structures including silver nanoparticles that were activated with magnetic nanoparticles (MNPs). Emulsion solvent evaporation technique was employed to synthesize three types of shells: (i) (PVP-PEG) (100:20, w/w), (ii) (PLGA-PEG) (100:20, w/w), and (iii) (PLGA-PEG) (50:10, w/w) introduced as D1, D2, and D3 respectively. The in vitro release of AmB was examined in aqueous medium phosphate buffer saline (PBS) in pH~ 7.2. Several spectroscopy methods characterized the structure and properties of the nanoparticles. In vitro antifungal activity of pure AmB and D1, D2, and D3 was studied against
Candida albicans
(
C. albicans
). The results explained that frequency of drug released from D2 at the first 10 h was (18%) that was compared with D1 (30%) and D3 (24%) at the same time. D2 had more efficient and longer targeted controlled release. The findings showed that D2 can be used as an effective carrier for in vitro targeted controlled release and D2 and D3 had powerful activity against
C. albicans
.</description><subject>Amphotericin B</subject><subject>Antibiotics</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Aqueous solutions</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Controlled release</subject><subject>Core-shell structure</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Evaporation</subject><subject>Fungicides</subject><subject>In vitro methods and tests</subject><subject>Iron oxides</subject><subject>Nanoparticles</subject><subject>Polyethylene glycol</subject><subject>Polylactide-co-glycolide</subject><subject>Polymers</subject><subject>Polyvinylpyrrolidone</subject><subject>Shells</subject><subject>Silver</subject><subject>Spectroscopy</subject><issn>0273-2289</issn><issn>1559-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kF1LwzAYhYMoOKd_wKuA13F5k7ZpvOumm4PBBKe3pU3Tj9E1M2mF_XujFbzz5v2A55wDB6FboPdAqZg5YBQooSAJ5RADoWdoAmHoXybhHE0oE5wwFstLdOXcnlJgcSgmKH-0Q4Ufddt8anvCpsTJ4VibXttGNR2e4762ZqhqvDBWk9dat60_D0fjml7jeeZ0gU2HXzarZJZUs6Xm2-ABrzv83vTW4J12_TW6KLPW6ZvfPUVvy6fd4plstqv1ItkQxWPZEyggVpKzUhZcCiYiqXQeqVBqEZciC5QQOctkGDLIJI1FRGkIeR5RxZUsC8mn6G70PVrzMfjgdG8G2_nIlAUAng547Ck2Usoa56wu06NtDpk9pUDT7y7TscvUd5n-dOnnFPFR5DzcVdr-Wf-j-gJBR3QY</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Sadat Akhavi, Shiva</creator><creator>Moradi Dehaghi, Shahram</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>20200601</creationdate><title>Drug Delivery of Amphotericin B through Core-Shell Composite Based on PLGA/Ag/Fe3O4: In Vitro Test</title><author>Sadat Akhavi, Shiva ; 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Emulsion solvent evaporation technique was employed to synthesize three types of shells: (i) (PVP-PEG) (100:20, w/w), (ii) (PLGA-PEG) (100:20, w/w), and (iii) (PLGA-PEG) (50:10, w/w) introduced as D1, D2, and D3 respectively. The in vitro release of AmB was examined in aqueous medium phosphate buffer saline (PBS) in pH~ 7.2. Several spectroscopy methods characterized the structure and properties of the nanoparticles. In vitro antifungal activity of pure AmB and D1, D2, and D3 was studied against
Candida albicans
(
C. albicans
). The results explained that frequency of drug released from D2 at the first 10 h was (18%) that was compared with D1 (30%) and D3 (24%) at the same time. D2 had more efficient and longer targeted controlled release. The findings showed that D2 can be used as an effective carrier for in vitro targeted controlled release and D2 and D3 had powerful activity against
C. albicans
.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12010-019-03181-0</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0273-2289 |
| ispartof | Applied biochemistry and biotechnology, 2020-06, Vol.191 (2), p.496-510 |
| issn | 0273-2289 1559-0291 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Amphotericin B Antibiotics Antifungal activity Antifungal agents Aqueous solutions Biochemistry Biocompatibility Biodegradability Biodegradation Biotechnology Chemistry Chemistry and Materials Science Controlled release Core-shell structure Drug delivery Drug delivery systems Evaporation Fungicides In vitro methods and tests Iron oxides Nanoparticles Polyethylene glycol Polylactide-co-glycolide Polymers Polyvinylpyrrolidone Shells Silver Spectroscopy |
| title | Drug Delivery of Amphotericin B through Core-Shell Composite Based on PLGA/Ag/Fe3O4: In Vitro Test |
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