Synthesis of novel heterocyclic compounds containing pyrimidine nucleus using the Biginelli reaction: Antiproliferative activity and docking studies

In a single reaction step, pyrimidine derivatives (4a‐p) were synthesized from the triple reaction of aromatic aldehydes (1), ethyl cyanoacetate (2), and some guanyl hydrazone derivatives (3a‐n). These compounds were tested as in vitro against two types of cancerous cell lines, namely, a human colon...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2020-06, Vol.57 (6), p.2615-2627
Hauptverfasser:	Çağlar Yavuz, Sevtap, Akkoç, Senem, Türkmenoğlu, Burçin, Sarıpınar, Emin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Anticancer properties Antiproliferatives Biotechnology Colon Derivatives Heterocyclic compounds Hydrazones Molecular docking
Online-Zugang:	Volltext
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