Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy

Sepsis is a life-threatening condition. Polydatin (PD), a small natural compound from Polygonum cuspidatum , possesses antioxidant and anti-inflammatory properties. However, the protective mechanism of PD on sepsis-induced acute myocardial damage is still unclear. The aim of this study was to invest...

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Veröffentlicht in:	Inflammation 2020-06, Vol.43 (3), p.785-795
Hauptverfasser:	Yuan, Xiaoyan, Chen, Guo, Guo, Dongfeng, Xu, Lei, Gu, Yongfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Antioxidants Apoptosis Autophagy Autophagy - drug effects Autophagy - physiology Biomedical and Life Sciences Biomedicine Cardiomyopathies - chemically induced Cardiomyopathies - drug therapy Cardiomyopathies - metabolism Cardiomyopathy Cecum Cell Line Enzyme-linked immunosorbent assay Flow cytometry Glucosides - pharmacology Glucosides - therapeutic use Immunofluorescence Immunohistochemistry Immunology Inflammation Interleukin 6 Internal Medicine Lipopolysaccharides Lipopolysaccharides - toxicity Male Myocardium - metabolism Original Article Pathology Phagocytosis Pharmacology/Toxicology Rats Rats, Sprague-Dawley Rheumatology Sepsis Sepsis - chemically induced Sepsis - drug therapy Sepsis - metabolism Sirtuins - biosynthesis Stilbenes - pharmacology Stilbenes - therapeutic use Tumor necrosis factor-α Western blotting
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