High affinity of 4‐(4‐(dimethylamino)styryl)‐N‐methylpyridinium transport for assessing organic cation drugs in hepatocellular carcinoma cells

Human organic cation transporter 1 (hOCT1) and human organic cation transporter 3 (hOCT3) are highly expressed in hepatocytes and play important roles in cationic drug absorption, distribution, and elimination. A previous study demonstrated that downregulation of hOCT1 and hOCT3 mRNA was related to...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2020-06, Vol.34 (3), p.365-379
Hauptverfasser:	Jinakote, Metee, Ontawong, Atcharaporn, Soodvilai, Sunhapas, Pimta, Jeerawat, Pasachan, Tipthida, Chatsudthipong, Varanuj, Srimaroeng, Chutima
Format:	Artikel
Sprache:	eng
Schlagworte:	1‐methyl‐4‐phenylpyridinium (MPP+) 4‐(4‐(dimethylamino)styryl)‐N‐methylpyridinium (ASP+) Affinity Biological Transport - physiology Carcinoma, Hepatocellular - metabolism Cations Cations - metabolism Cell Line, Tumor Depolarization Drug delivery Drug delivery systems Fluorescence Hep G2 Cells Hepatocellular carcinoma hepatocellular carcinoma cells (HepG2) Hepatocytes Hepatocytes - metabolism Humans Liver cancer Liver Neoplasms - metabolism Membrane potential Metformin Metformin - metabolism MPP mRNA Organic cation transporter organic cation transporter 1 Organic Cation Transporter 1 - metabolism Organic Cation Transporter 2 - metabolism organic cation transporter 3 Paclitaxel Paclitaxel - metabolism Pharmacology Pyridinium Compounds - metabolism Transport rate
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