Cytotoxicity, cellular uptake and apoptotic responses in human coronary artery endothelial cells exposed to ultrasmall superparamagnetic iron oxide nanoparticles

Ultrasmall superparamagnetic iron oxide nanoparticles (USPION) possess reactive surfaces, are metabolized and exhibit unique magnetic properties. These properties are desirable for designing novel theranostic biomedical products; however, toxicity mechanisms of USPION are not completely elucidated....

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Veröffentlicht in:	Journal of applied toxicology 2020-07, Vol.40 (7), p.918-930
Hauptverfasser:	Palacios‐Hernandez, Teresa, Diaz‐Diestra, Daysi M., Nguyen, Alexander K., Skoog, Shelby A., Vijaya Chikkaveeraiah, Bhaskara, Tang, Xing, Wu, Yong, Petrochenko, Peter E., Sussman, Eric M., Goering, Peter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Apoptosis Biocompatibility Caspase Cell interactions Confocal microscopy Coronary artery Coronary vessels Cytotoxicity Deoxyribonucleic acid DNA Electrophoresis Endothelial cells Exposure Fluorescence Gel electrophoresis Imaging Internalization Iron oxides Light scattering Localization Lysosomes Magnetic properties Microscopy Nanoparticles overendocytosis Photon correlation spectroscopy Staining Time dependence Toxicity Transmission electron microscopy ultrasmall superparamagnetic iron oxide nanoparticles Zeta potential
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