Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model

Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of biochemical and molecular toxicology 2020-06, Vol.34 (6), p.e22483-n/a
Hauptverfasser: Abubakar, Kabeer, Mailafiya, Maryam M., Chiroma, Samaila M., Danmaigoro, Abubakar, Zyoud, Tawfiq Y. T., Abdul Rahim, Ezamin, Abu Bakar Zakaria, Md Zuki
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 6
container_start_page e22483
container_title Journal of biochemical and molecular toxicology
container_volume 34
creator Abubakar, Kabeer
Mailafiya, Maryam M.
Chiroma, Samaila M.
Danmaigoro, Abubakar
Zyoud, Tawfiq Y. T.
Abdul Rahim, Ezamin
Abu Bakar Zakaria, Md Zuki
description Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepatorenal toxicity in a rat model. Methods Thirty‐six male Sprague‐Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead‐treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric‐tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive‐coupled plasma mass spectrometry techniques. Results Pb‐administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions The results in this study suggested that curcumin attenuates Pb‐induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.
doi_str_mv 10.1002/jbt.22483
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2409650795</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2409650795</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3883-3437fb70e37b841bd22ce4fee2658d82d0996dc2df275c577a59f07da84e2c723</originalsourceid><addsrcrecordid>eNp1kL9OwzAQhy0EoqUw8ALIEhNDWseJ42QsFX9ViaXMkWOfi6skLk4CdOMReEaeBLcpbEw-n777dPdD6Dwk45AQOlkV7ZjSOI0O0DAkWRaQOAkPdzULkoSTATppmhUhhGWcHaNBREPKCI-HaDmtoDTWida8AQatQbbYaiw7J7vK1NjWuAShvj-_TK06CQq_QCVaW9qlkaLEot521r7joPb_1n4YadoN9rMCey-urILyFB1pUTZwtn9H6Pn2ZjG7D-ZPdw-z6TyQUZpGQRRHXBecQMSLNA4LRamEWAPQhKUqpcpflyhJlaacSca5YJkmXIk0Bio5jUbosveunX3toGnzle2cX6zJaUyyxF-dMU9d9ZR0tmkc6HztTCXcJg9Jvo0095Hmu0g9e7E3dkUF6o_8zdADkx54NyVs_jflj9eLXvkDgFKBnA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2409650795</pqid></control><display><type>article</type><title>Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Abubakar, Kabeer ; Mailafiya, Maryam M. ; Chiroma, Samaila M. ; Danmaigoro, Abubakar ; Zyoud, Tawfiq Y. T. ; Abdul Rahim, Ezamin ; Abu Bakar Zakaria, Md Zuki</creator><creatorcontrib>Abubakar, Kabeer ; Mailafiya, Maryam M. ; Chiroma, Samaila M. ; Danmaigoro, Abubakar ; Zyoud, Tawfiq Y. T. ; Abdul Rahim, Ezamin ; Abu Bakar Zakaria, Md Zuki</creatorcontrib><description>Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepatorenal toxicity in a rat model. Methods Thirty‐six male Sprague‐Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead‐treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric‐tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive‐coupled plasma mass spectrometry techniques. Results Pb‐administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions The results in this study suggested that curcumin attenuates Pb‐induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.22483</identifier><identifier>PMID: 32125074</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antioxidants - administration &amp; dosage ; Chelating Agents - administration &amp; dosage ; Chelation ; Curcuma ; Curcumin ; Curcumin - administration &amp; dosage ; Disease Models, Animal ; Heavy metals ; Hematology ; hepatorenal toxicity ; ICP‐MS ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Lead ; Lead acetates ; Lead Poisoning - blood ; Lead Poisoning - therapy ; lead toxicity ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; Mass spectrometry ; Mass spectroscopy ; Organometallic Compounds - metabolism ; Organometallic Compounds - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Phytotherapy - methods ; Plant Extracts - administration &amp; dosage ; Rats ; Rats, Sprague-Dawley ; Toxicity ; Treatment Outcome</subject><ispartof>Journal of biochemical and molecular toxicology, 2020-06, Vol.34 (6), p.e22483-n/a</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-3437fb70e37b841bd22ce4fee2658d82d0996dc2df275c577a59f07da84e2c723</citedby><cites>FETCH-LOGICAL-c3883-3437fb70e37b841bd22ce4fee2658d82d0996dc2df275c577a59f07da84e2c723</cites><orcidid>0000-0001-7552-0383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.22483$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.22483$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32125074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abubakar, Kabeer</creatorcontrib><creatorcontrib>Mailafiya, Maryam M.</creatorcontrib><creatorcontrib>Chiroma, Samaila M.</creatorcontrib><creatorcontrib>Danmaigoro, Abubakar</creatorcontrib><creatorcontrib>Zyoud, Tawfiq Y. T.</creatorcontrib><creatorcontrib>Abdul Rahim, Ezamin</creatorcontrib><creatorcontrib>Abu Bakar Zakaria, Md Zuki</creatorcontrib><title>Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepatorenal toxicity in a rat model. Methods Thirty‐six male Sprague‐Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead‐treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric‐tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive‐coupled plasma mass spectrometry techniques. Results Pb‐administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions The results in this study suggested that curcumin attenuates Pb‐induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.</description><subject>Animals</subject><subject>Antioxidants - administration &amp; dosage</subject><subject>Chelating Agents - administration &amp; dosage</subject><subject>Chelation</subject><subject>Curcuma</subject><subject>Curcumin</subject><subject>Curcumin - administration &amp; dosage</subject><subject>Disease Models, Animal</subject><subject>Heavy metals</subject><subject>Hematology</subject><subject>hepatorenal toxicity</subject><subject>ICP‐MS</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Lead</subject><subject>Lead acetates</subject><subject>Lead Poisoning - blood</subject><subject>Lead Poisoning - therapy</subject><subject>lead toxicity</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Organometallic Compounds - metabolism</subject><subject>Organometallic Compounds - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - administration &amp; dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicity</subject><subject>Treatment Outcome</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL9OwzAQhy0EoqUw8ALIEhNDWseJ42QsFX9ViaXMkWOfi6skLk4CdOMReEaeBLcpbEw-n777dPdD6Dwk45AQOlkV7ZjSOI0O0DAkWRaQOAkPdzULkoSTATppmhUhhGWcHaNBREPKCI-HaDmtoDTWida8AQatQbbYaiw7J7vK1NjWuAShvj-_TK06CQq_QCVaW9qlkaLEot521r7joPb_1n4YadoN9rMCey-urILyFB1pUTZwtn9H6Pn2ZjG7D-ZPdw-z6TyQUZpGQRRHXBecQMSLNA4LRamEWAPQhKUqpcpflyhJlaacSca5YJkmXIk0Bio5jUbosveunX3toGnzle2cX6zJaUyyxF-dMU9d9ZR0tmkc6HztTCXcJg9Jvo0095Hmu0g9e7E3dkUF6o_8zdADkx54NyVs_jflj9eLXvkDgFKBnA</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Abubakar, Kabeer</creator><creator>Mailafiya, Maryam M.</creator><creator>Chiroma, Samaila M.</creator><creator>Danmaigoro, Abubakar</creator><creator>Zyoud, Tawfiq Y. T.</creator><creator>Abdul Rahim, Ezamin</creator><creator>Abu Bakar Zakaria, Md Zuki</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-7552-0383</orcidid></search><sort><creationdate>202006</creationdate><title>Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model</title><author>Abubakar, Kabeer ; Mailafiya, Maryam M. ; Chiroma, Samaila M. ; Danmaigoro, Abubakar ; Zyoud, Tawfiq Y. T. ; Abdul Rahim, Ezamin ; Abu Bakar Zakaria, Md Zuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-3437fb70e37b841bd22ce4fee2658d82d0996dc2df275c577a59f07da84e2c723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antioxidants - administration &amp; dosage</topic><topic>Chelating Agents - administration &amp; dosage</topic><topic>Chelation</topic><topic>Curcuma</topic><topic>Curcumin</topic><topic>Curcumin - administration &amp; dosage</topic><topic>Disease Models, Animal</topic><topic>Heavy metals</topic><topic>Hematology</topic><topic>hepatorenal toxicity</topic><topic>ICP‐MS</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Lead</topic><topic>Lead acetates</topic><topic>Lead Poisoning - blood</topic><topic>Lead Poisoning - therapy</topic><topic>lead toxicity</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Organometallic Compounds - metabolism</topic><topic>Organometallic Compounds - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - administration &amp; dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Toxicity</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abubakar, Kabeer</creatorcontrib><creatorcontrib>Mailafiya, Maryam M.</creatorcontrib><creatorcontrib>Chiroma, Samaila M.</creatorcontrib><creatorcontrib>Danmaigoro, Abubakar</creatorcontrib><creatorcontrib>Zyoud, Tawfiq Y. T.</creatorcontrib><creatorcontrib>Abdul Rahim, Ezamin</creatorcontrib><creatorcontrib>Abu Bakar Zakaria, Md Zuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abubakar, Kabeer</au><au>Mailafiya, Maryam M.</au><au>Chiroma, Samaila M.</au><au>Danmaigoro, Abubakar</au><au>Zyoud, Tawfiq Y. T.</au><au>Abdul Rahim, Ezamin</au><au>Abu Bakar Zakaria, Md Zuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>34</volume><issue>6</issue><spage>e22483</spage><epage>n/a</epage><pages>e22483-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>Introduction Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb‐induced hepatorenal toxicity in a rat model. Methods Thirty‐six male Sprague‐Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead‐treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric‐tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive‐coupled plasma mass spectrometry techniques. Results Pb‐administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions The results in this study suggested that curcumin attenuates Pb‐induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32125074</pmid><doi>10.1002/jbt.22483</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-7552-0383</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1095-6670
ispartof Journal of biochemical and molecular toxicology, 2020-06, Vol.34 (6), p.e22483-n/a
issn 1095-6670
1099-0461
language eng
recordid cdi_proquest_journals_2409650795
source Wiley-Blackwell Journals; MEDLINE
subjects Animals
Antioxidants - administration & dosage
Chelating Agents - administration & dosage
Chelation
Curcuma
Curcumin
Curcumin - administration & dosage
Disease Models, Animal
Heavy metals
Hematology
hepatorenal toxicity
ICP‐MS
Kidney - drug effects
Kidney - metabolism
Kidneys
Lead
Lead acetates
Lead Poisoning - blood
Lead Poisoning - therapy
lead toxicity
Liver
Liver - drug effects
Liver - metabolism
Male
Mass spectrometry
Mass spectroscopy
Organometallic Compounds - metabolism
Organometallic Compounds - toxicity
Oxidative stress
Oxidative Stress - drug effects
Phytotherapy - methods
Plant Extracts - administration & dosage
Rats
Rats, Sprague-Dawley
Toxicity
Treatment Outcome
title Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A50%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ameliorative%20effect%20of%20curcumin%20on%20lead%E2%80%90induced%20hematological%20and%20hepatorenal%20toxicity%20in%20a%20rat%20model&rft.jtitle=Journal%20of%20biochemical%20and%20molecular%20toxicology&rft.au=Abubakar,%20Kabeer&rft.date=2020-06&rft.volume=34&rft.issue=6&rft.spage=e22483&rft.epage=n/a&rft.pages=e22483-n/a&rft.issn=1095-6670&rft.eissn=1099-0461&rft_id=info:doi/10.1002/jbt.22483&rft_dat=%3Cproquest_cross%3E2409650795%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2409650795&rft_id=info:pmid/32125074&rfr_iscdi=true