Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery
Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2020-06, Vol.59 (25), p.10008-10012 |
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| creator | Chen, Chao Ni, Xiang Tian, Han‐Wen Liu, Qian Guo, Dong‐Sheng Ding, Dan |
| description | Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co‐assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image‐guided cancer surgery.
Calix[5]arene‐based supramolecular AIE nanodots were synthesized with high quantum yields in water by virtue of the host–guest complexation. The absorbed excitation energy was mostly focused on fluorescence emission, leading to an ultrahigh signal‐to‐background ratio in fluorescence‐image‐guided cancer surgery. |
| doi_str_mv | 10.1002/anie.201916430 |
| format | Article |
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Calix[5]arene‐based supramolecular AIE nanodots were synthesized with high quantum yields in water by virtue of the host–guest complexation. The absorbed excitation energy was mostly focused on fluorescence emission, leading to an ultrahigh signal‐to‐background ratio in fluorescence‐image‐guided cancer surgery.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201916430</identifier><identifier>PMID: 31981392</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>aggregation-induced emission ; Animals ; Biocompatibility ; Calixarenes ; Calixarenes - chemistry ; Calixarenes - toxicity ; Cancer ; Cancer surgery ; Carcinoma - pathology ; Cytotoxicity ; Deactivation ; Emission ; Emissions ; Energy dissipation ; Fluorescence ; fluorescence-guided surgery ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - toxicity ; Gastric cancer ; In vivo methods and tests ; Mice ; nanodots ; Nanostructures ; Neoplasms - surgery ; Optical Imaging ; Peritoneum ; Reactive oxygen species ; supramolecular nanoparticles ; Surgery ; Surgery, Computer-Assisted - methods ; Toxicity</subject><ispartof>Angewandte Chemie International Edition, 2020-06, Vol.59 (25), p.10008-10012</ispartof><rights>2020 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4100-5eded835286cbcef3d2010b3f939a18717c7b4bf54260b2ae43cf2c3454409bf3</citedby><cites>FETCH-LOGICAL-c4100-5eded835286cbcef3d2010b3f939a18717c7b4bf54260b2ae43cf2c3454409bf3</cites><orcidid>0000-0003-1873-6510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201916430$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201916430$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31981392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Ni, Xiang</creatorcontrib><creatorcontrib>Tian, Han‐Wen</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Guo, Dong‐Sheng</creatorcontrib><creatorcontrib>Ding, Dan</creatorcontrib><title>Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co‐assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image‐guided cancer surgery.
Calix[5]arene‐based supramolecular AIE nanodots were synthesized with high quantum yields in water by virtue of the host–guest complexation. The absorbed excitation energy was mostly focused on fluorescence emission, leading to an ultrahigh signal‐to‐background ratio in fluorescence‐image‐guided cancer surgery.</description><subject>aggregation-induced emission</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Calixarenes</subject><subject>Calixarenes - chemistry</subject><subject>Calixarenes - toxicity</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Carcinoma - pathology</subject><subject>Cytotoxicity</subject><subject>Deactivation</subject><subject>Emission</subject><subject>Emissions</subject><subject>Energy dissipation</subject><subject>Fluorescence</subject><subject>fluorescence-guided surgery</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - toxicity</subject><subject>Gastric cancer</subject><subject>In vivo methods and tests</subject><subject>Mice</subject><subject>nanodots</subject><subject>Nanostructures</subject><subject>Neoplasms - surgery</subject><subject>Optical Imaging</subject><subject>Peritoneum</subject><subject>Reactive oxygen species</subject><subject>supramolecular nanoparticles</subject><subject>Surgery</subject><subject>Surgery, Computer-Assisted - methods</subject><subject>Toxicity</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9O3DAQxq2qqFDotUdkqeds_S-b5LhkF4iE4FA4R44z2TVKnGWcQHPrI_Q5-lh9knpZ_hx7Gmv0-74Zz0fIV85mnDHxXTsLM8F4xudKsg_kiMeCRzJJ5MfwVlJGSRrzQ_LZ-_vApymbfyKHkmcpl5k4In9y3dqfGsHB31-_z7SHmv4Yt6i7vgUzthrpoljRZT94-mSHDb2060070cJtbGWHQF_3DnVt9WAfgS7B6IlqVwdgAPSTH6CjOfbeW7emTY_0rh0wjHHePivO27FH8AacAVp0er3b42K0dbDOdWhi2AfXgNMJOWh06-HLSz0md-er2_wyurq5KPLFVWRUOEkUQ5CmMhbp3FQGGlmH87BKNpnMNE8TnpikUlUTKzFnldCgpGmEkSpWimVVI4_Jt73vFvuHEfxQ3vcjujCyFIGIVSy5DNRsT5nd5xCacou20ziVnJW7aMpdNOVbNEFw-mI7Vh3Ub_hrFgHI9sCTbWH6j125uC5W7-b_AE80oAA</recordid><startdate>20200615</startdate><enddate>20200615</enddate><creator>Chen, Chao</creator><creator>Ni, Xiang</creator><creator>Tian, Han‐Wen</creator><creator>Liu, Qian</creator><creator>Guo, Dong‐Sheng</creator><creator>Ding, Dan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-1873-6510</orcidid></search><sort><creationdate>20200615</creationdate><title>Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery</title><author>Chen, Chao ; Ni, Xiang ; Tian, Han‐Wen ; Liu, Qian ; Guo, Dong‐Sheng ; Ding, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4100-5eded835286cbcef3d2010b3f939a18717c7b4bf54260b2ae43cf2c3454409bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>aggregation-induced emission</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Calixarenes</topic><topic>Calixarenes - chemistry</topic><topic>Calixarenes - toxicity</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Carcinoma - pathology</topic><topic>Cytotoxicity</topic><topic>Deactivation</topic><topic>Emission</topic><topic>Emissions</topic><topic>Energy dissipation</topic><topic>Fluorescence</topic><topic>fluorescence-guided surgery</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent Dyes - toxicity</topic><topic>Gastric cancer</topic><topic>In vivo methods and tests</topic><topic>Mice</topic><topic>nanodots</topic><topic>Nanostructures</topic><topic>Neoplasms - surgery</topic><topic>Optical Imaging</topic><topic>Peritoneum</topic><topic>Reactive oxygen species</topic><topic>supramolecular nanoparticles</topic><topic>Surgery</topic><topic>Surgery, Computer-Assisted - methods</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Ni, Xiang</creatorcontrib><creatorcontrib>Tian, Han‐Wen</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Guo, Dong‐Sheng</creatorcontrib><creatorcontrib>Ding, Dan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chao</au><au>Ni, Xiang</au><au>Tian, Han‐Wen</au><au>Liu, Qian</au><au>Guo, Dong‐Sheng</au><au>Ding, Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>59</volume><issue>25</issue><spage>10008</spage><epage>10012</epage><pages>10008-10012</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co‐assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image‐guided cancer surgery.
Calix[5]arene‐based supramolecular AIE nanodots were synthesized with high quantum yields in water by virtue of the host–guest complexation. The absorbed excitation energy was mostly focused on fluorescence emission, leading to an ultrahigh signal‐to‐background ratio in fluorescence‐image‐guided cancer surgery.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31981392</pmid><doi>10.1002/anie.201916430</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0003-1873-6510</orcidid></addata></record> |
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| subjects | aggregation-induced emission Animals Biocompatibility Calixarenes Calixarenes - chemistry Calixarenes - toxicity Cancer Cancer surgery Carcinoma - pathology Cytotoxicity Deactivation Emission Emissions Energy dissipation Fluorescence fluorescence-guided surgery Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity Gastric cancer In vivo methods and tests Mice nanodots Nanostructures Neoplasms - surgery Optical Imaging Peritoneum Reactive oxygen species supramolecular nanoparticles Surgery Surgery, Computer-Assisted - methods Toxicity |
| title | Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery |
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