Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy
The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achi...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2020-06, Vol.59 (25), p.9914-9921 |
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| creator | Sun, Wenjing Luo, Li Feng, Yushuo Cai, Yuting Zhuang, Yixi Xie, Rong‐Jun Chen, Xiaoyuan Chen, Hongmin |
| description | The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy (X‐PDT) with negligible side effects. The aggregates of glutathione‐protected gold clusters (GCs) assembled through a cationic polymer enhanced the X‐ray‐excited luminescence by 5.2‐fold. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE‐Au effectively triggered the generation of reactive oxygen species with an order‐of‐magnitude reduction in the X‐ray dose, enabling highly effective cancer treatment.
Cancer‐killing clusters: Aggregation‐induced emission gold clustoluminogens (AIE‐Au) for X‐ray‐induced photodynamic therapy (X‐PDT) were designed. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, AIE‐AuX‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. |
| doi_str_mv | 10.1002/anie.201908712 |
| format | Article |
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Cancer‐killing clusters: Aggregation‐induced emission gold clustoluminogens (AIE‐Au) for X‐ray‐induced photodynamic therapy (X‐PDT) were designed. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, AIE‐AuX‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201908712</identifier><identifier>PMID: 31418982</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Agglomeration ; aggregation-induced emission ; Animals ; Au clustoluminogens ; Cationic polymerization ; Emission ; Emissions ; Free radicals ; Glutathione ; Gold ; Gold - chemistry ; Hydroxyl Radical ; Hydroxyl radicals ; Irradiation ; Luminescence ; Mice ; Mice, Inbred BALB C ; Nanoparticles ; Neoplasms - radiotherapy ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents ; Polymers ; Radiation Dosage ; Radiation therapy ; Radiation-Sensitizing Agents - chemistry ; Radiosensitizers ; radiotherapy ; Reactive oxygen species ; Side effects ; X-Rays ; Xenograft Model Antitumor Assays</subject><ispartof>Angewandte Chemie International Edition, 2020-06, Vol.59 (25), p.9914-9921</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-e99cf022ee67e4c05b5995bac05ac2993154268d109d85f571adbc7ba0faf9193</citedby><cites>FETCH-LOGICAL-c4762-e99cf022ee67e4c05b5995bac05ac2993154268d109d85f571adbc7ba0faf9193</cites><orcidid>0000-0002-9622-0870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201908712$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201908712$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31418982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Feng, Yushuo</creatorcontrib><creatorcontrib>Cai, Yuting</creatorcontrib><creatorcontrib>Zhuang, Yixi</creatorcontrib><creatorcontrib>Xie, Rong‐Jun</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><creatorcontrib>Chen, Hongmin</creatorcontrib><title>Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy (X‐PDT) with negligible side effects. The aggregates of glutathione‐protected gold clusters (GCs) assembled through a cationic polymer enhanced the X‐ray‐excited luminescence by 5.2‐fold. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE‐Au effectively triggered the generation of reactive oxygen species with an order‐of‐magnitude reduction in the X‐ray dose, enabling highly effective cancer treatment.
Cancer‐killing clusters: Aggregation‐induced emission gold clustoluminogens (AIE‐Au) for X‐ray‐induced photodynamic therapy (X‐PDT) were designed. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, AIE‐AuX‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect.</description><subject>Agglomeration</subject><subject>aggregation-induced emission</subject><subject>Animals</subject><subject>Au clustoluminogens</subject><subject>Cationic polymerization</subject><subject>Emission</subject><subject>Emissions</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Hydroxyl Radical</subject><subject>Hydroxyl radicals</subject><subject>Irradiation</subject><subject>Luminescence</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoparticles</subject><subject>Neoplasms - radiotherapy</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents</subject><subject>Polymers</subject><subject>Radiation Dosage</subject><subject>Radiation therapy</subject><subject>Radiation-Sensitizing Agents - chemistry</subject><subject>Radiosensitizers</subject><subject>radiotherapy</subject><subject>Reactive oxygen species</subject><subject>Side effects</subject><subject>X-Rays</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLwzAYhoMobk6vHqXguTNJm6Y5jlnnYKiHCd5C2qZdR5vMpGX05k_wN_pLzNic3jx9Lx_P93zwAnCN4BhBiO-EquQYQ8RgTBE-AUNEMPIDSoNTl8Mg8GlM0ABcWLt2fBzD6BwMAhSimMV4COykLI0sRVtp9fXxOVd5l8ncS5rKWrfyZrrOvWnd2VbXXVMpXUplvUIbL1EroXbsQm_d5b220ntzwYj-j-hlpVud90o0VeYtV9KITX8JzgpRW3l1mCPw-pAsp4_-4nk2n04WfhbSCPuSsayAGEsZURlmkKSEMZIKl0SGGQsQCXEU5wiyPCYFoUjkaUZTAQtRMMSCEbjdezdGv3fStnytO6PcS45DyAhmUQAdNd5TmdHWGlnwjakaYXqOIN91zHcd82PH7uDmoO3SRuZH_KdUB7A9sK1q2f-j45OnefIr_waXgY2u</recordid><startdate>20200615</startdate><enddate>20200615</enddate><creator>Sun, Wenjing</creator><creator>Luo, Li</creator><creator>Feng, Yushuo</creator><creator>Cai, Yuting</creator><creator>Zhuang, Yixi</creator><creator>Xie, Rong‐Jun</creator><creator>Chen, Xiaoyuan</creator><creator>Chen, Hongmin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid></search><sort><creationdate>20200615</creationdate><title>Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy</title><author>Sun, Wenjing ; Luo, Li ; Feng, Yushuo ; Cai, Yuting ; Zhuang, Yixi ; Xie, Rong‐Jun ; Chen, Xiaoyuan ; Chen, Hongmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-e99cf022ee67e4c05b5995bac05ac2993154268d109d85f571adbc7ba0faf9193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Agglomeration</topic><topic>aggregation-induced emission</topic><topic>Animals</topic><topic>Au clustoluminogens</topic><topic>Cationic polymerization</topic><topic>Emission</topic><topic>Emissions</topic><topic>Free radicals</topic><topic>Glutathione</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Hydroxyl Radical</topic><topic>Hydroxyl radicals</topic><topic>Irradiation</topic><topic>Luminescence</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoparticles</topic><topic>Neoplasms - radiotherapy</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents</topic><topic>Polymers</topic><topic>Radiation Dosage</topic><topic>Radiation therapy</topic><topic>Radiation-Sensitizing Agents - chemistry</topic><topic>Radiosensitizers</topic><topic>radiotherapy</topic><topic>Reactive oxygen species</topic><topic>Side effects</topic><topic>X-Rays</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Feng, Yushuo</creatorcontrib><creatorcontrib>Cai, Yuting</creatorcontrib><creatorcontrib>Zhuang, Yixi</creatorcontrib><creatorcontrib>Xie, Rong‐Jun</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><creatorcontrib>Chen, Hongmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Wenjing</au><au>Luo, Li</au><au>Feng, Yushuo</au><au>Cai, Yuting</au><au>Zhuang, Yixi</au><au>Xie, Rong‐Jun</au><au>Chen, Xiaoyuan</au><au>Chen, Hongmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>59</volume><issue>25</issue><spage>9914</spage><epage>9921</epage><pages>9914-9921</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy (X‐PDT) with negligible side effects. The aggregates of glutathione‐protected gold clusters (GCs) assembled through a cationic polymer enhanced the X‐ray‐excited luminescence by 5.2‐fold. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE‐Au effectively triggered the generation of reactive oxygen species with an order‐of‐magnitude reduction in the X‐ray dose, enabling highly effective cancer treatment.
Cancer‐killing clusters: Aggregation‐induced emission gold clustoluminogens (AIE‐Au) for X‐ray‐induced photodynamic therapy (X‐PDT) were designed. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, AIE‐AuX‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31418982</pmid><doi>10.1002/anie.201908712</doi><tpages>8</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid></addata></record> |
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| subjects | Agglomeration aggregation-induced emission Animals Au clustoluminogens Cationic polymerization Emission Emissions Free radicals Glutathione Gold Gold - chemistry Hydroxyl Radical Hydroxyl radicals Irradiation Luminescence Mice Mice, Inbred BALB C Nanoparticles Neoplasms - radiotherapy Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents Polymers Radiation Dosage Radiation therapy Radiation-Sensitizing Agents - chemistry Radiosensitizers radiotherapy Reactive oxygen species Side effects X-Rays Xenograft Model Antitumor Assays |
| title | Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy |
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