Copper-catalyzed Tandem Cyclization to Access 4-Aminoquinoline Derivatives

Copper-catalyzed Tandem Cyclization to Access 4-Aminoquinoline Derivatives

An efficient and practical method for the synthesis of 4-aminoquinoline derivatives has been developed via copper-catalyzed cascade cyclization of 2-aminobenzonitrile and nitroolefins. This reaction proceeds through a consecutive Michael addition/cyclization/oxidization protocol, providing 4-aminoqu...

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Veröffentlicht in:Chemistry letters 2020-05, Vol.49 (5), p.526-529
Hauptverfasser: Sheng, Hui-Yang, Chen, Hui, Liao, Meng, Peng, Na, Yang, Mian, Cai, Qun, Liu, Yi
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Aminoquinolines
Copper
Derivatives
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container_end_page 529
container_issue 5
container_start_page 526
container_title Chemistry letters
container_volume 49
creator Sheng, Hui-Yang
Chen, Hui
Liao, Meng
Peng, Na
Yang, Mian
Cai, Qun
Liu, Yi
description An efficient and practical method for the synthesis of 4-aminoquinoline derivatives has been developed via copper-catalyzed cascade cyclization of 2-aminobenzonitrile and nitroolefins. This reaction proceeds through a consecutive Michael addition/cyclization/oxidization protocol, providing 4-aminoquinolines with moderate to excellent yields under mild conditions. This method features readily available materials, one-pot one-step operation, and proceeds without bases.
doi_str_mv 10.1246/cl.200053
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source Oxford University Press Journals All Titles (1996-Current)
subjects Aminoquinolines
Copper
Derivatives
title Copper-catalyzed Tandem Cyclization to Access 4-Aminoquinoline Derivatives
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