L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice

The neurodevelopmental toxicity of isoflurane has been proved by many studies, which makes it essential to explore the underline mechanisms and search for protective agents to attenuate its neurotoxcity. Accumulating evidence showed that L-theanine had neuroprotective effects on injured neurons and...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2020/06/01, Vol.43(6), pp.938-945
Hauptverfasser:	Chen, Yong, Lian, Fang, Lu, Qiang, Peng, Shengliang, Li, Jiahao, Huang, Song, Du, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Caspase-3 Cholecystokinin Cognitive ability DNA nucleotidylexotransferase Glycogen Glycogen synthase kinase 3 Immunofluorescence Isoflurane Kinases L-theanine Neonates neural stem cell Neural stem cells Neurodevelopmental disorders Neuroprotection neurotoxicity protein kinase B–glycogen synthase kinase 3 beta signaling pathway Rodents Signal transduction Stem cell transplantation Stem cells Theanine Toxicity Western blotting
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