Substituted adamantylphthalimides: Synthesis, antiviral and antiproliferative activity

In this study, three groups of adamantylphthalimides, bearing different substituents at the phthalimide moiety, N‐(4′‐R2)phthalimidoadamantanes (1–7), 3‐[N‐(4′‐R2)phthalimido]‐1‐adamantanols (8–10), and 3‐[N‐(4′‐R2)phthalimido]adamantane‐1‐carboxylic acids (11–15), were synthesized and screened agai...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2020-06, Vol.353 (6), p.e2000024-n/a
Hauptverfasser:	Mandić, Leo, Benčić, Patricia, Mlinarić‐Majerski, Kata, Liekens, Sandra, Snoeck, Robert, Andrei, Graciela, Kralj, Marijeta, Basarić, Nikola
Format:	Artikel
Sprache:	eng
Schlagworte:	adamantane Adamantane - analogs & derivatives Adamantane - chemistry Adamantane - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antiproliferative activity antiviral activity Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Cell Line Cell Proliferation - drug effects Cytomegalovirus - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Herpesvirus 3, Human - drug effects Humans Microbial Sensitivity Tests Molecular Structure phthalimide Phthalimides - chemical synthesis Phthalimides - chemistry Phthalimides - pharmacology Structure-Activity Relationship
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