γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies
We report a facile and friendly to the environment method for the preparation of superparamagnetic γ-Fe 2 O 3 /Gd 2 O 3 -chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibra...
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| Veröffentlicht in: | Applied physics. A, Materials science & processing Materials science & processing, 2020-06, Vol.126 (6), Article 471 |
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| container_title | Applied physics. A, Materials science & processing |
| container_volume | 126 |
| creator | Lemine, O. M. Alanazi, Amal Albert, Emmellie Laura Hjiri, M. M’hamed, Mohamed Ould Alrub, S. Abu Alkaoud, A. Abdullah, Che Azurahanim Che |
| description | We report a facile and friendly to the environment method for the preparation of superparamagnetic γ-Fe
2
O
3
/Gd
2
O
3
-chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer, Scanning electron microscopy and Energy-dispersive X-ray spectroscopy (EDAX). In addition, the heating efficiency and biocompatibility with human cells are reported. XRD patterns indicated that the most dominant crystalline phase is γ-Fe
2
O
3
with the presence of chitosan in the coated sample. FT-IR and EDAX confirmed the presence of chitosan on the surface of the nanostructure. Magnetic measurements showed the superparamagnetic behavior with decrease in saturation after coating due to diamagnetic nature of chitosan. This behavior is corroborated by the successfully fitting into Langevin function for paramagnetic materials. The specific absorption rate under an alternating magnetic field is investigated as a function of the concentration and amplitude of the applied magnetic field. A mean heating efficiency of 35 W/g is obtained for concentration of 15 mg/ml at 332 kHz and 170 Oe. It was found that the heating efficiency of the nanocomposite can be tuned by changing parameters such as concentration and amplitude of applied AC magnetic field. Cell viability assay of coated nanocomposite showed low cytotoxic effect on A549 cells line (human alveolar epithelial). In overall, the prepared nanocomposite can be used as potential candidate for magnetic hyperthermia application due to their superparamagnetic nature, heating ability and biocompatibility with human cells. |
| doi_str_mv | 10.1007/s00339-020-03649-5 |
| format | Article |
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2
O
3
/Gd
2
O
3
-chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer, Scanning electron microscopy and Energy-dispersive X-ray spectroscopy (EDAX). In addition, the heating efficiency and biocompatibility with human cells are reported. XRD patterns indicated that the most dominant crystalline phase is γ-Fe
2
O
3
with the presence of chitosan in the coated sample. FT-IR and EDAX confirmed the presence of chitosan on the surface of the nanostructure. Magnetic measurements showed the superparamagnetic behavior with decrease in saturation after coating due to diamagnetic nature of chitosan. This behavior is corroborated by the successfully fitting into Langevin function for paramagnetic materials. The specific absorption rate under an alternating magnetic field is investigated as a function of the concentration and amplitude of the applied magnetic field. A mean heating efficiency of 35 W/g is obtained for concentration of 15 mg/ml at 332 kHz and 170 Oe. It was found that the heating efficiency of the nanocomposite can be tuned by changing parameters such as concentration and amplitude of applied AC magnetic field. Cell viability assay of coated nanocomposite showed low cytotoxic effect on A549 cells line (human alveolar epithelial). In overall, the prepared nanocomposite can be used as potential candidate for magnetic hyperthermia application due to their superparamagnetic nature, heating ability and biocompatibility with human cells.</description><identifier>ISSN: 0947-8396</identifier><identifier>EISSN: 1432-0630</identifier><identifier>DOI: 10.1007/s00339-020-03649-5</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amplitudes ; Applied physics ; Biocompatibility ; Characterization and Evaluation of Materials ; Chitosan ; Condensed Matter Physics ; Diamagnetism ; Efficiency ; Fever ; Fourier transforms ; Gadolinium oxides ; Heating ; Hyperthermia ; Infrared spectroscopy ; Machines ; Magnetic fields ; Magnetic measurement ; Magnetometers ; Manufacturing ; Materials science ; Nanocomposites ; Nanotechnology ; Optical and Electronic Materials ; Paramagnetic materials ; Physics ; Physics and Astronomy ; Processes ; Spectrum analysis ; Surfaces and Interfaces ; Thin Films ; Toxicity ; X-ray diffraction</subject><ispartof>Applied physics. A, Materials science & processing, 2020-06, Vol.126 (6), Article 471</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-19970fb7988f4ddd8640c8b7b6a934a173286faf0551fe9ef54a48d4a4b566de3</citedby><cites>FETCH-LOGICAL-c319t-19970fb7988f4ddd8640c8b7b6a934a173286faf0551fe9ef54a48d4a4b566de3</cites><orcidid>0000-0002-2516-3661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00339-020-03649-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00339-020-03649-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Lemine, O. M.</creatorcontrib><creatorcontrib>Alanazi, Amal</creatorcontrib><creatorcontrib>Albert, Emmellie Laura</creatorcontrib><creatorcontrib>Hjiri, M.</creatorcontrib><creatorcontrib>M’hamed, Mohamed Ould</creatorcontrib><creatorcontrib>Alrub, S. Abu</creatorcontrib><creatorcontrib>Alkaoud, A.</creatorcontrib><creatorcontrib>Abdullah, Che Azurahanim Che</creatorcontrib><title>γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies</title><title>Applied physics. A, Materials science & processing</title><addtitle>Appl. Phys. A</addtitle><description>We report a facile and friendly to the environment method for the preparation of superparamagnetic γ-Fe
2
O
3
/Gd
2
O
3
-chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer, Scanning electron microscopy and Energy-dispersive X-ray spectroscopy (EDAX). In addition, the heating efficiency and biocompatibility with human cells are reported. XRD patterns indicated that the most dominant crystalline phase is γ-Fe
2
O
3
with the presence of chitosan in the coated sample. FT-IR and EDAX confirmed the presence of chitosan on the surface of the nanostructure. Magnetic measurements showed the superparamagnetic behavior with decrease in saturation after coating due to diamagnetic nature of chitosan. This behavior is corroborated by the successfully fitting into Langevin function for paramagnetic materials. The specific absorption rate under an alternating magnetic field is investigated as a function of the concentration and amplitude of the applied magnetic field. A mean heating efficiency of 35 W/g is obtained for concentration of 15 mg/ml at 332 kHz and 170 Oe. It was found that the heating efficiency of the nanocomposite can be tuned by changing parameters such as concentration and amplitude of applied AC magnetic field. Cell viability assay of coated nanocomposite showed low cytotoxic effect on A549 cells line (human alveolar epithelial). In overall, the prepared nanocomposite can be used as potential candidate for magnetic hyperthermia application due to their superparamagnetic nature, heating ability and biocompatibility with human cells.</description><subject>Amplitudes</subject><subject>Applied physics</subject><subject>Biocompatibility</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chitosan</subject><subject>Condensed Matter Physics</subject><subject>Diamagnetism</subject><subject>Efficiency</subject><subject>Fever</subject><subject>Fourier transforms</subject><subject>Gadolinium oxides</subject><subject>Heating</subject><subject>Hyperthermia</subject><subject>Infrared spectroscopy</subject><subject>Machines</subject><subject>Magnetic fields</subject><subject>Magnetic measurement</subject><subject>Magnetometers</subject><subject>Manufacturing</subject><subject>Materials science</subject><subject>Nanocomposites</subject><subject>Nanotechnology</subject><subject>Optical and Electronic Materials</subject><subject>Paramagnetic materials</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Processes</subject><subject>Spectrum analysis</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Toxicity</subject><subject>X-ray diffraction</subject><issn>0947-8396</issn><issn>1432-0630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1qHDEQhUWIIRM7F8hKkK1lV0tqteSdMf4JGLxJ1kKjlmZkZqSOpIb0JXwZ38NnspIxyc61qIKq972Ch9DXDs46gOG8ADCmCFAgwARXpP-AVh1nlIBg8BGtQPGBSKbEJ_S5lEdoxSldoaeXZ3Lj6AM7vx1bJ3Ybaiom4r3ZRFeDxdHEZNN-SiVUh33KeLtMLtety_tgsJmmXbCmhhQvcKl5tnXOZnf6z-AUb107xw123gcbXLQLNnHEdqmppt9tVZdGzmNw5QQdebMr7svbPEY_b65_XN2R-4fb71eX98SyTlXSKTWAXw9KSs_HcZSCg5XrYS2MYtx0A6NSeOOh7zvvlPM9N1yOra17IUbHjtG3g--U06_Zlaof05xje6kph0EKKgfVVPSgsjmVkp3XUw57kxfdgf6Tuz7krlvu-m_uum8QO0CliePG5f_W71CvzQmJPQ</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Lemine, O. M.</creator><creator>Alanazi, Amal</creator><creator>Albert, Emmellie Laura</creator><creator>Hjiri, M.</creator><creator>M’hamed, Mohamed Ould</creator><creator>Alrub, S. Abu</creator><creator>Alkaoud, A.</creator><creator>Abdullah, Che Azurahanim Che</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2516-3661</orcidid></search><sort><creationdate>20200601</creationdate><title>γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies</title><author>Lemine, O. M. ; Alanazi, Amal ; Albert, Emmellie Laura ; Hjiri, M. ; M’hamed, Mohamed Ould ; Alrub, S. Abu ; Alkaoud, A. ; Abdullah, Che Azurahanim Che</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-19970fb7988f4ddd8640c8b7b6a934a173286faf0551fe9ef54a48d4a4b566de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amplitudes</topic><topic>Applied physics</topic><topic>Biocompatibility</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chitosan</topic><topic>Condensed Matter Physics</topic><topic>Diamagnetism</topic><topic>Efficiency</topic><topic>Fever</topic><topic>Fourier transforms</topic><topic>Gadolinium oxides</topic><topic>Heating</topic><topic>Hyperthermia</topic><topic>Infrared spectroscopy</topic><topic>Machines</topic><topic>Magnetic fields</topic><topic>Magnetic measurement</topic><topic>Magnetometers</topic><topic>Manufacturing</topic><topic>Materials science</topic><topic>Nanocomposites</topic><topic>Nanotechnology</topic><topic>Optical and Electronic Materials</topic><topic>Paramagnetic materials</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Processes</topic><topic>Spectrum analysis</topic><topic>Surfaces and Interfaces</topic><topic>Thin Films</topic><topic>Toxicity</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemine, O. M.</creatorcontrib><creatorcontrib>Alanazi, Amal</creatorcontrib><creatorcontrib>Albert, Emmellie Laura</creatorcontrib><creatorcontrib>Hjiri, M.</creatorcontrib><creatorcontrib>M’hamed, Mohamed Ould</creatorcontrib><creatorcontrib>Alrub, S. Abu</creatorcontrib><creatorcontrib>Alkaoud, A.</creatorcontrib><creatorcontrib>Abdullah, Che Azurahanim Che</creatorcontrib><collection>CrossRef</collection><jtitle>Applied physics. A, Materials science & processing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemine, O. M.</au><au>Alanazi, Amal</au><au>Albert, Emmellie Laura</au><au>Hjiri, M.</au><au>M’hamed, Mohamed Ould</au><au>Alrub, S. Abu</au><au>Alkaoud, A.</au><au>Abdullah, Che Azurahanim Che</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies</atitle><jtitle>Applied physics. A, Materials science & processing</jtitle><stitle>Appl. Phys. A</stitle><date>2020-06-01</date><risdate>2020</risdate><volume>126</volume><issue>6</issue><artnum>471</artnum><issn>0947-8396</issn><eissn>1432-0630</eissn><abstract>We report a facile and friendly to the environment method for the preparation of superparamagnetic γ-Fe
2
O
3
/Gd
2
O
3
-chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer, Scanning electron microscopy and Energy-dispersive X-ray spectroscopy (EDAX). In addition, the heating efficiency and biocompatibility with human cells are reported. XRD patterns indicated that the most dominant crystalline phase is γ-Fe
2
O
3
with the presence of chitosan in the coated sample. FT-IR and EDAX confirmed the presence of chitosan on the surface of the nanostructure. Magnetic measurements showed the superparamagnetic behavior with decrease in saturation after coating due to diamagnetic nature of chitosan. This behavior is corroborated by the successfully fitting into Langevin function for paramagnetic materials. The specific absorption rate under an alternating magnetic field is investigated as a function of the concentration and amplitude of the applied magnetic field. A mean heating efficiency of 35 W/g is obtained for concentration of 15 mg/ml at 332 kHz and 170 Oe. It was found that the heating efficiency of the nanocomposite can be tuned by changing parameters such as concentration and amplitude of applied AC magnetic field. Cell viability assay of coated nanocomposite showed low cytotoxic effect on A549 cells line (human alveolar epithelial). In overall, the prepared nanocomposite can be used as potential candidate for magnetic hyperthermia application due to their superparamagnetic nature, heating ability and biocompatibility with human cells.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00339-020-03649-5</doi><orcidid>https://orcid.org/0000-0002-2516-3661</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0947-8396 |
| ispartof | Applied physics. A, Materials science & processing, 2020-06, Vol.126 (6), Article 471 |
| issn | 0947-8396 1432-0630 |
| language | eng |
| recordid | cdi_proquest_journals_2407862879 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Amplitudes Applied physics Biocompatibility Characterization and Evaluation of Materials Chitosan Condensed Matter Physics Diamagnetism Efficiency Fever Fourier transforms Gadolinium oxides Heating Hyperthermia Infrared spectroscopy Machines Magnetic fields Magnetic measurement Magnetometers Manufacturing Materials science Nanocomposites Nanotechnology Optical and Electronic Materials Paramagnetic materials Physics Physics and Astronomy Processes Spectrum analysis Surfaces and Interfaces Thin Films Toxicity X-ray diffraction |
| title | γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies |
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