The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice

Background and Aims The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 and the Hippo pathway remains l...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-06, Vol.71 (6), p.1988-2004
Hauptverfasser:	Feng, Xue, Lu, Tiantian, Li, Jinhui, Yang, Ruizeng, Hu, Liqiao, Ye, Yi, Mao, Feifei, He, Lingli, Xu, Jinjin, Wang, Zuoyun, Liu, Yingbin, Zhang, Yonglong, Ji, Hongbin, Zhao, Yun, Cheng, Shuqun, Tian, Wei, Zhang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Carcinogenesis - metabolism Cell Proliferation Disease Models, Animal DNA-Binding Proteins - metabolism Feedback Gene Expression Regulation, Neoplastic Hepatology Homeostasis Interferon Interferon regulatory factor Interferon regulatory factor 2 Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Muscle Proteins - metabolism Protein-Serine-Threonine Kinases - metabolism Proteins Signal Transduction Transcription Factors - metabolism Tumor suppressor genes Tumor Suppressor Proteins - metabolism Tumorigenesis Yes-associated protein
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