Hypoxia‐Inducible Factor‐2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin‐6

Background and Aims Acetaminophen (APAP) overdose represents the most frequent cause of acute liver failure, resulting in death or liver transplantation in more than one third of patients in the United States. The effectiveness of the only antidote, N‐acetylcysteine, declines rapidly after APAP inge...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-06, Vol.71 (6), p.2105-2117
Hauptverfasser:	Gao, Rachel Y., Wang, Meng, Liu, Qihui, Feng, Dechun, Wen, Yankai, Xia, Yang, Colgan, Sean P., Eltzschig, Holger K., Ju, Cynthia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Acetylcysteine Analgesics, Non-Narcotic - toxicity Animals Basic Helix-Loop-Helix Transcription Factors - immunology Basic Helix-Loop-Helix Transcription Factors - metabolism Cellular Reprogramming Chemical and Drug Induced Liver Injury - immunology Chemical and Drug Induced Liver Injury - metabolism Cytokines Detoxification Gene deletion Gene Expression Hepatocytes Hepatology Hepatotoxicity Hypoxia Hypoxia - immunology Hypoxia - metabolism Immune response Immunity, Innate Inactivation, Metabolic Innate immunity Interleukin 6 Interleukin-6 - metabolism Kupffer Cells - metabolism Liver Liver diseases Liver transplantation Macrophages Mice Mice, Knockout Myeloid cells Overdose Serum levels Signal Transduction Therapeutic applications Transcription activation
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