Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease
Inhaled nanoparticles constitute a potential health hazard due to their size‐dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle‐induced acute phase respo...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-05, Vol.16 (21), p.e1907476-n/a |
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| creator | Hadrup, Niels Zhernovkov, Vadim Jacobsen, Nicklas Raun Voss, Carola Strunz, Maximilian Ansari, Meshal Schiller, Herbert B. Halappanavar, Sabina Poulsen, Sarah S. Kholodenko, Boris Stoeger, Tobias Saber, Anne Thoustrup Vogel, Ulla |
| description | Inhaled nanoparticles constitute a potential health hazard due to their size‐dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle‐induced acute phase response may be an important mechanism of action of particle‐induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
Cardiovascular disease is an important contributor to particle‐induced diseases. Inhalation of (nano)particles induces acute phase response, a known risk factor for cardiovascular disease. New evidence is reviewed, showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease. |
| doi_str_mv | 10.1002/smll.201907476 |
| format | Article |
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Cardiovascular disease is an important contributor to particle‐induced diseases. Inhalation of (nano)particles induces acute phase response, a known risk factor for cardiovascular disease. New evidence is reviewed, showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.201907476</identifier><identifier>PMID: 32227434</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acute-Phase Reaction - chemically induced ; atherosclerosis ; Cardiovascular disease ; cardiovascular diseases ; Cardiovascular Diseases - chemically induced ; C‐reactive protein ; Health hazards ; Health risk assessment ; Humans ; Inhalation Exposure - adverse effects ; Lung - drug effects ; Nanomaterials ; Nanoparticles ; Nanoparticles - toxicity ; Nanotechnology ; Occupational diseases ; Occupational Diseases - chemically induced ; occupational exposure ; Particle Size ; Particulate Matter - toxicity ; Respiration ; Risk assessment ; Serum Amyloid A</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2020-05, Vol.16 (21), p.e1907476-n/a</ispartof><rights>2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5426-a3d3240f3a8c7efdeb4a7227fd325f55cf3210710999374988d2a256bff898933</citedby><cites>FETCH-LOGICAL-c5426-a3d3240f3a8c7efdeb4a7227fd325f55cf3210710999374988d2a256bff898933</cites><orcidid>0000-0001-6807-1524</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsmll.201907476$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsmll.201907476$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32227434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hadrup, Niels</creatorcontrib><creatorcontrib>Zhernovkov, Vadim</creatorcontrib><creatorcontrib>Jacobsen, Nicklas Raun</creatorcontrib><creatorcontrib>Voss, Carola</creatorcontrib><creatorcontrib>Strunz, Maximilian</creatorcontrib><creatorcontrib>Ansari, Meshal</creatorcontrib><creatorcontrib>Schiller, Herbert B.</creatorcontrib><creatorcontrib>Halappanavar, Sabina</creatorcontrib><creatorcontrib>Poulsen, Sarah S.</creatorcontrib><creatorcontrib>Kholodenko, Boris</creatorcontrib><creatorcontrib>Stoeger, Tobias</creatorcontrib><creatorcontrib>Saber, Anne Thoustrup</creatorcontrib><creatorcontrib>Vogel, Ulla</creatorcontrib><title>Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>Inhaled nanoparticles constitute a potential health hazard due to their size‐dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle‐induced acute phase response may be an important mechanism of action of particle‐induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
Cardiovascular disease is an important contributor to particle‐induced diseases. Inhalation of (nano)particles induces acute phase response, a known risk factor for cardiovascular disease. New evidence is reviewed, showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease.</description><subject>Acute-Phase Reaction - chemically induced</subject><subject>atherosclerosis</subject><subject>Cardiovascular disease</subject><subject>cardiovascular diseases</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>C‐reactive protein</subject><subject>Health hazards</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Lung - drug effects</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - toxicity</subject><subject>Nanotechnology</subject><subject>Occupational diseases</subject><subject>Occupational Diseases - chemically induced</subject><subject>occupational exposure</subject><subject>Particle Size</subject><subject>Particulate Matter - toxicity</subject><subject>Respiration</subject><subject>Risk assessment</subject><subject>Serum Amyloid A</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi0EolBYGZElFhhafEnieCzlVqkFxGWOXMemrpI42AmoG4_AM_IkuGopI4vPkc_n71g_AEcY9TFC5NyXRdEnCHPEIpZsgT2cYNpLUsK3Nz1GHbDv_RwhiknEdkGHEkJYRKM9YAeybRR8mAmv4KPyta1CIzwU8MLYwr4aKQo4UXImKuPL788vq8MxkI2xFbQant6Jyp7VwjVGFiqMRlXeSpXDoXC5se_Cy7YQDl4ar8KOA7CjReHV4bp2wcv11fPwtje-vxkNB-OejCOS9ATNKYmQpiKVTOlcTSPBwp91uI51HEtNCUYMI845ZRFP05wIEidTrVOeckq74GTlrZ19a5VvsrltXRVWZsHLCOYsSQLVX1HSWe-d0lntTCncIsMoW-abLfPNNvmGB8drbTstVb7BfwMNAF8BH6ZQi3902dNkPP6T_wAJBYn5</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Hadrup, Niels</creator><creator>Zhernovkov, Vadim</creator><creator>Jacobsen, Nicklas Raun</creator><creator>Voss, Carola</creator><creator>Strunz, Maximilian</creator><creator>Ansari, Meshal</creator><creator>Schiller, Herbert B.</creator><creator>Halappanavar, Sabina</creator><creator>Poulsen, Sarah S.</creator><creator>Kholodenko, Boris</creator><creator>Stoeger, Tobias</creator><creator>Saber, Anne Thoustrup</creator><creator>Vogel, Ulla</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-6807-1524</orcidid></search><sort><creationdate>20200501</creationdate><title>Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease</title><author>Hadrup, Niels ; Zhernovkov, Vadim ; Jacobsen, Nicklas Raun ; Voss, Carola ; Strunz, Maximilian ; Ansari, Meshal ; Schiller, Herbert B. ; Halappanavar, Sabina ; Poulsen, Sarah S. ; Kholodenko, Boris ; Stoeger, Tobias ; Saber, Anne Thoustrup ; Vogel, Ulla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5426-a3d3240f3a8c7efdeb4a7227fd325f55cf3210710999374988d2a256bff898933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute-Phase Reaction - chemically induced</topic><topic>atherosclerosis</topic><topic>Cardiovascular disease</topic><topic>cardiovascular diseases</topic><topic>Cardiovascular Diseases - chemically induced</topic><topic>C‐reactive protein</topic><topic>Health hazards</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Lung - drug effects</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanoparticles - toxicity</topic><topic>Nanotechnology</topic><topic>Occupational diseases</topic><topic>Occupational Diseases - chemically induced</topic><topic>occupational exposure</topic><topic>Particle Size</topic><topic>Particulate Matter - toxicity</topic><topic>Respiration</topic><topic>Risk assessment</topic><topic>Serum Amyloid A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hadrup, Niels</creatorcontrib><creatorcontrib>Zhernovkov, Vadim</creatorcontrib><creatorcontrib>Jacobsen, Nicklas Raun</creatorcontrib><creatorcontrib>Voss, Carola</creatorcontrib><creatorcontrib>Strunz, Maximilian</creatorcontrib><creatorcontrib>Ansari, Meshal</creatorcontrib><creatorcontrib>Schiller, Herbert B.</creatorcontrib><creatorcontrib>Halappanavar, Sabina</creatorcontrib><creatorcontrib>Poulsen, Sarah S.</creatorcontrib><creatorcontrib>Kholodenko, Boris</creatorcontrib><creatorcontrib>Stoeger, Tobias</creatorcontrib><creatorcontrib>Saber, Anne Thoustrup</creatorcontrib><creatorcontrib>Vogel, Ulla</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Free Archive</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hadrup, Niels</au><au>Zhernovkov, Vadim</au><au>Jacobsen, Nicklas Raun</au><au>Voss, Carola</au><au>Strunz, Maximilian</au><au>Ansari, Meshal</au><au>Schiller, Herbert B.</au><au>Halappanavar, Sabina</au><au>Poulsen, Sarah S.</au><au>Kholodenko, Boris</au><au>Stoeger, Tobias</au><au>Saber, Anne Thoustrup</au><au>Vogel, Ulla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>16</volume><issue>21</issue><spage>e1907476</spage><epage>n/a</epage><pages>e1907476-n/a</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>Inhaled nanoparticles constitute a potential health hazard due to their size‐dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle‐induced acute phase response may be an important mechanism of action of particle‐induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
Cardiovascular disease is an important contributor to particle‐induced diseases. Inhalation of (nano)particles induces acute phase response, a known risk factor for cardiovascular disease. New evidence is reviewed, showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response and risk of cardiovascular disease. Particle‐induced acute phase response provides a means for risk assessment of particle‐induced cardiovascular disease.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32227434</pmid><doi>10.1002/smll.201907476</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6807-1524</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute-Phase Reaction - chemically induced atherosclerosis Cardiovascular disease cardiovascular diseases Cardiovascular Diseases - chemically induced C‐reactive protein Health hazards Health risk assessment Humans Inhalation Exposure - adverse effects Lung - drug effects Nanomaterials Nanoparticles Nanoparticles - toxicity Nanotechnology Occupational diseases Occupational Diseases - chemically induced occupational exposure Particle Size Particulate Matter - toxicity Respiration Risk assessment Serum Amyloid A |
| title | Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease |
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