Second-generation 4,5,6,7-tetrahydrobenzo[ d ]thiazoles as novel DNA gyrase inhibitors

DNA gyrase and topoisomerase IV are essential bacterial enzymes, and in the fight against bacterial resistance, they are important targets for the development of novel antibacterial drugs. Building from our first generation of 4,5,6,7-tetrahydrobenzo[ ]thiazole-based DNA gyrase inhibitors, we design...

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Veröffentlicht in:	Future medicinal chemistry 2020-02, Vol.12 (4), p.277-297
Hauptverfasser:	Lamut, Andraž, Skok, Žiga, Barančoková, Michaela, Gutierrez, Lucas J, Cruz, Cristina D, Tammela, Päivi, Draskovits, Gábor, Szili, Petra Éva, Nyerges, Ákos, Pál, Csaba, Molek, Peter, Bratkovič, Tomaž, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Enriz, Ricardo D, Kikelj, Danijel, Tomašič, Tihomir
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antifungal agents Benzothiazoles - chemistry Benzothiazoles - pharmacology Binding sites Deoxyribonucleic acid DNA DNA Gyrase - metabolism DNA topoisomerase DNA topoisomerase IV Dose-Response Relationship, Drug Drug development E coli Enzymes Gram-positive bacteria Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - enzymology Gram-Positive Bacteria - growth & development Humans Kinases Microbial Sensitivity Tests Microorganisms Models, Molecular Molecular Structure Multidrug resistant organisms Strains (organisms) Structure-Activity Relationship Thiazoles Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology
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